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Study · Animal study (in vivo) · cow · 2000

3 results

Efficacy of two non-antibiotic therapies, oxytocin and topical liniment, against bovine staphylococcal mastitis.

Knight CH, Fitzpatrick JL, Logue DN, Platt DJ

The Veterinary record1 Mar 2000Cited by 11 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In cows challenged with Staphylococcus aureus, oxytocin reduced bacterial numbers significantly relative to the negative control.

    In plain wordsIn cows with a staph udder infection, oxytocin lowered bacteria in milk more than massage alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseBacterial numbers in milk
    Study

    cown = 8

    intramammary Staphylococcus aureus challenge
    Comparator
    Massage alone (negative control)
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated · one weekAs given in this study (cow).

    Source sentences

    Summary
    Relative to the negative control, the liniment had no significant effect, but both oxytocin and the antibiotic reduced the numbers of bacteria significantly and did not differ significantly in efficacy.
    2 context sentences
    Summary · context
    Eight cows were challenged by a single quarter intramammary infusion of a relatively low-virulence strain of Staphylococcus aureus on four occasions five weeks apart and, after each challenge, each cow received one of four treatments, according to a duplicated Latin-square design.
    Summary · context
    The massage treatments were applied at every milking for three weeks, oxytocin was given for one week, and the antibiotic was given after three successive milkings.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In cows challenged with Staphylococcus aureus, oxytocin and the intramammary antibiotic did not differ significantly in efficacy.

    In plain wordsIn cows with a staph udder infection, oxytocin worked about as well as an udder antibiotic.

    Peptide
    Oxytocin
    Outcome
    No significant changeBacterial numbers, oxytocin versus intramammary antibiotic
    Study

    cown = 8

    intramammary Staphylococcus aureus challenge
    Comparator
    Proprietary intramammary antibiotic
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated · one weekAs given in this study (cow).

    Source sentences

    Summary
    Relative to the negative control, the liniment had no significant effect, but both oxytocin and the antibiotic reduced the numbers of bacteria significantly and did not differ significantly in efficacy.
    2 context sentences
    Summary · context
    Eight cows were challenged by a single quarter intramammary infusion of a relatively low-virulence strain of Staphylococcus aureus on four occasions five weeks apart and, after each challenge, each cow received one of four treatments, according to a duplicated Latin-square design.
    Summary · context
    The massage treatments were applied at every milking for three weeks, oxytocin was given for one week, and the antibiotic was given after three successive milkings.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In cows challenged with Staphylococcus aureus, none of the treatments, oxytocin included, completely eliminated bacteria from all the cows.

    In plain wordsIn cows with a staph udder infection, no treatment, oxytocin included, cleared the bacteria from every cow.

    Peptide
    Oxytocin
    Outcome
    No significant changeComplete elimination of bacteria
    Study

    cown = 8

    intramammary Staphylococcus aureus challenge
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated · one weekAs given in this study (cow).

    Source sentences

    Summary
    None of the treatments completely eliminated bacteria from all the cows.
    2 context sentences
    Summary · context
    Eight cows were challenged by a single quarter intramammary infusion of a relatively low-virulence strain of Staphylococcus aureus on four occasions five weeks apart and, after each challenge, each cow received one of four treatments, according to a duplicated Latin-square design.
    Summary · context
    The massage treatments were applied at every milking for three weeks, oxytocin was given for one week, and the antibiotic was given after three successive milkings.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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