[The effect of semax and mexidol on the course of acute pancreatitis in rats].

Ivanov IuV, Iasnetsov VV

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2000Cited by 2 (Europe PMC)

PMID10763109PepBankPUB-10763109

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute pancreatitis, a single administration of semax (or mexidol) markedly reduced the loss of animals, to 10-13%.
In plain wordsIn rats with pancreatitis, one dose of semax (or mexidol) markedly lowered animal deaths, to 10-13%.
Peptide
Semax
Outcome
DecreaseLoss of animals in acute pancreatitis
Study
ratsn: not reported in source
Acute pancreatitis
Outcome group
Mortality · Gastrointestinal
Studied dose
Dose not stated · intraductal or intraperitoneal · single administrationAs given in this study (rats).
Measurements
Animal loss
10 to 13%
semax or mexidol
Source sentences
Summary
a single intraductal or intraperitoneal administration of semax or mexidol markedly reduces the loss of experimental animals (to 10-13%)
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of semax and mexidol on the course of acute pancreatitis in rats was studied in comparison with the action of contrical, fluorouracil, and dibunol.
Report a problemFND-1076310901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute pancreatitis, semax (or mexidol) decreased hyperfermentemia.
In plain wordsIn rats with pancreatitis, semax (or mexidol) lowered the raised enzyme levels in blood.
Peptide
Semax
Outcome
DecreaseHyperfermentemia
Study
ratsn: not reported in source
Acute pancreatitis
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
Dose not stated · intraductal or intraperitoneal · single administrationAs given in this study (rats).
Source sentences
Summary
a single intraductal or intraperitoneal administration of semax or mexidol markedly reduces the loss of experimental animals (to 10-13%), decreases hyperfermentemia
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of semax and mexidol on the course of acute pancreatitis in rats was studied in comparison with the action of contrical, fluorouracil, and dibunol.
Report a problemFND-1076310902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute pancreatitis, semax (or mexidol) decreased activation of lipid peroxidation.
In plain wordsIn rats with pancreatitis, semax (or mexidol) lowered fat-damage activity (lipid peroxidation).
Peptide
Semax
Outcome
DecreaseLipid peroxidation activation
Study
ratsn: not reported in source
Acute pancreatitis
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
Dose not stated · intraductal or intraperitoneal · single administrationAs given in this study (rats).
Source sentences
Summary
a single intraductal or intraperitoneal administration of semax or mexidol markedly reduces the loss of experimental animals (to 10-13%), decreases hyperfermentemia, lipid peroxidation activation
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of semax and mexidol on the course of acute pancreatitis in rats was studied in comparison with the action of contrical, fluorouracil, and dibunol.
Report a problemFND-1076310903
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute pancreatitis, semax (or mexidol) decreased vascular permeability.
In plain wordsIn rats with pancreatitis, semax (or mexidol) lowered leakiness of blood vessels.
Peptide
Semax
Outcome
DecreaseVascular permeability
Study
ratsn: not reported in source
Acute pancreatitis
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
Dose not stated · intraductal or intraperitoneal · single administrationAs given in this study (rats).
Source sentences
Summary
a single intraductal or intraperitoneal administration of semax or mexidol markedly reduces the loss of experimental animals (to 10-13%), decreases hyperfermentemia, lipid peroxidation activation, and vascular permeability
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of semax and mexidol on the course of acute pancreatitis in rats was studied in comparison with the action of contrical, fluorouracil, and dibunol.
Report a problemFND-1076310904
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute pancreatitis, semax (or mexidol) improved microcirculation.
In plain wordsIn rats with pancreatitis, semax (or mexidol) improved small blood vessel flow.
Peptide
Semax
Outcome
IncreaseMicrocirculation
Study
ratsn: not reported in source
Acute pancreatitis
Outcome group
Vascular function · Gastrointestinal
Studied dose
Dose not stated · intraductal or intraperitoneal · single administrationAs given in this study (rats).
Source sentences
Summary
a single intraductal or intraperitoneal administration of semax or mexidol markedly reduces the loss of experimental animals (to 10-13%), decreases hyperfermentemia, lipid peroxidation activation, and vascular permeability, improves microcirculation
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of semax and mexidol on the course of acute pancreatitis in rats was studied in comparison with the action of contrical, fluorouracil, and dibunol.
Report a problemFND-1076310905
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute pancreatitis, semax (or mexidol) accelerated healing of damaged pancreatic zones by substitutional repair of pancreatic acini without coarse fibrous changes.
In plain wordsIn rats with pancreatitis, semax (or mexidol) sped up healing of damaged pancreas areas without heavy scarring.
Peptide
Semax
Outcome
IncreaseHealing of damaged pancreatic zones
Study
ratsn: not reported in source
Acute pancreatitis
Outcome group
Wound healing · Gastrointestinal
Studied dose
Dose not stated · intraductal or intraperitoneal · single administrationAs given in this study (rats).
Source sentences
Summary
accelerates healing of the damaged pancreatic zones by substitutional repair of pancreatic acini not accompanied by coarse fibrous changes in the parenchyma
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of semax and mexidol on the course of acute pancreatitis in rats was studied in comparison with the action of contrical, fluorouracil, and dibunol.
Report a problemFND-1076310906
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute pancreatitis, intraductal semax and mexidol were more effective than contrical, fluorouracil and dibunol.
In plain wordsIn rats with pancreatitis, semax and mexidol given into the pancreatic duct worked better than three comparison drugs.
Peptide
Semax
Outcome
IncreaseEfficacy versus contrical, fluorouracil and dibunol (intraductal)
Study
ratsn: not reported in source
Acute pancreatitis
Comparator
Contrical, fluorouracil and dibunol
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · intraductal · single administrationAs given in this study (rats).
Source sentences
Summary
Upon the intraductal administration, semax and mexidol were more effective than contrical, fluorouracil, and dibunol.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of semax and mexidol on the course of acute pancreatitis in rats was studied in comparison with the action of contrical, fluorouracil, and dibunol.
Report a problemFND-1076310907

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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