Skip to content

Study · Animal study (in vivo) · rat · 2000

5 results

The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation.

Williams DL, Kaplan JM, Grill HJ

Endocrinology1 Apr 2000Cited by 127 (Europe PMC)

PMID10746636 (opens in a new tab)DOI10.1210/endo.141.4.7410 (opens in a new tab)PepBankPUB-10746636
Source linkPubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MTII delivered above the dorsal motor nucleus of the vagus suppressed 2-h food intake by 50%.

    In plain wordsIn rats, melanotan II given near a brain vagus nucleus cut food intake by half over 2 hours.

    Peptide
    Melanotan II
    Outcome
    Decrease2-h food intake after MTII at the DMX
    Study

    ratn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · unilateral cannula above the DMXAs given in this study (rat).

    Measurements

    Food intake suppression
    50%
    2-h

    Source sentences

    Summary
    MTII markedly suppressed 2-h (50%)
    1 context sentence
    Summary · context
    To explore the possibility that the DMX contributes to 4th-icv MC4-R effects, we delivered doses of MTII and SHU9119 that are subthreshold for ventricular response unilaterally through a cannula centered above the DMX.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MTII delivered above the dorsal motor nucleus of the vagus suppressed 4-h food intake by 50%.

    In plain wordsIn rats, melanotan II given near a brain vagus nucleus cut food intake by half over 4 hours.

    Peptide
    Melanotan II
    Outcome
    Decrease4-h food intake after MTII at the DMX
    Study

    ratn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · unilateral cannula above the DMXAs given in this study (rat).

    Measurements

    Food intake suppression
    50%
    4-h

    Source sentences

    Summary
    4-h (50%), and 24-h (33%) intake.
    1 context sentence
    Summary · context
    To explore the possibility that the DMX contributes to 4th-icv MC4-R effects, we delivered doses of MTII and SHU9119 that are subthreshold for ventricular response unilaterally through a cannula centered above the DMX.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MTII delivered above the dorsal motor nucleus of the vagus suppressed 24-h food intake by 33%.

    In plain wordsIn rats, melanotan II given near a brain vagus nucleus cut food intake by a third over 24 hours.

    Peptide
    Melanotan II
    Outcome
    Decrease24-h food intake after MTII at the DMX
    Study

    ratn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · unilateral cannula above the DMXAs given in this study (rat).

    Measurements

    Food intake suppression
    33%
    24-h

    Source sentences

    Summary
    24-h (33%) intake.
    1 context sentence
    Summary · context
    To explore the possibility that the DMX contributes to 4th-icv MC4-R effects, we delivered doses of MTII and SHU9119 that are subthreshold for ventricular response unilaterally through a cannula centered above the DMX.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subdiaphragmatic vagotomy, fourth-ventricle MTII suppressed 2-, 4- and 24-h liquid diet intake by approximately 80%.

    In plain wordsIn rats with the vagus nerve cut below the diaphragm, melanotan II still cut food intake by about 80%.

    Peptide
    Melanotan II
    Outcome
    DecreaseLiquid diet intake after 4th-icv MTII in vagotomized rats
    Study

    ratn: not reported in source

    subdiaphragmatic vagotomy
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · fourth intracerebroventricularAs given in this study (rat).

    Measurements

    Liquid diet intake suppression
    80%
    vagotomized rats

    Source sentences

    Summary
    MTII suppressed 2-, 4-, and 24-h liquid diet intake (approximately 80%)
    1 context sentence
    Summary · context
    We investigated possible vagal mediation of 4th-icv MTII effects by giving the agonist to rats with subdiaphragmatic vagotomy.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, fourth-ventricle MTII suppressed intake to the same extent in vagotomized and surgical control rats.

    In plain wordsIn rats, melanotan II cut food intake equally in rats with and without the vagus nerve cut.

    Peptide
    Melanotan II
    Outcome
    No significant changeLiquid diet intake suppression, vagotomized versus surgical control rats
    Study

    ratn: not reported in source

    subdiaphragmatic vagotomy
    Comparator
    Surgical control rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · fourth intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    MTII suppressed 2-, 4-, and 24-h liquid diet intake (approximately 80%) to the same extent in vagotomized and surgical control rats.
    1 context sentence
    Summary · context
    We investigated possible vagal mediation of 4th-icv MTII effects by giving the agonist to rats with subdiaphragmatic vagotomy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.