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Study · Observational study · n = 27 · 2000

3 results

Hormonal treatment may harm the germ cells in 1 to 3-year-old boys with cryptorchidism.

Cortes D, Thorup J, Visfeldt J

The Journal of urology1 Apr 2000Cited by 61 (Europe PMC)

PMID10737531 (opens in a new tab)DOI10.1016/s0022-5347(05)67763-4 (opens in a new tab)PepBankPUB-10737531
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanObservational studySafety outcome

    In boys with cryptorchidism, HCG and gonadotropin releasing hormone influenced germ cells equally.

    In plain wordsIn boys with cryptorchidism, HCG and gonadotropin releasing hormone had equal effects on germ cells.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    Direction not reportedGerm cell effects versus GnRH
    Study

    n = 27

    Comparator
    Gonadotropin releasing hormone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Gonadotropin releasing hormone and HCG influenced germ cells equally.
    2 context sentences
    Summary · context
    We measured the number of spermatogonia per tubule at orchiopexy in 72 consecutive boys with cryptorchidism who underwent simultaneous testicular biopsy.
    Summary · context
    In 19 patients gonadotropin releasing hormone was unsuccessful, while 8 received HCG and 45 underwent orchiopexy without hormonal therapy.

Studies that did not test the peptide alone2

In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking hCG (human chorionic gonadotropin).

  1. 02HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studySafety outcome

    In boys with cryptorchidism, unsuccessful hormonal treatment including HCG was associated with fewer spermatogonia per tubule than surgery alone.

    In plain wordsIn boys with cryptorchidism, pooled unsuccessful hormone treatments including HCG were linked to fewer germ cells than surgery alone.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    DecreaseSpermatogonia per tubule after pooled hormonal treatment
    Study

    n = 72

    Comparator
    Surgery alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    P value for spermatogonia per tubule comparison
    < 0.05 p value
    surgery only versus unsuccessful pooled hormonal treatment

    Source sentences

    Summary
    Patients who underwent surgery only had a higher number of spermatogonia per tubule than those in whom hormonal treatment was unsuccessful (p<0.05).
    2 context sentences
    Summary · context
    We measured the number of spermatogonia per tubule at orchiopexy in 72 consecutive boys with cryptorchidism who underwent simultaneous testicular biopsy.
    Summary · context
    In 19 patients gonadotropin releasing hormone was unsuccessful, while 8 received HCG and 45 underwent orchiopexy without hormonal therapy.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  2. 03HumanNot a test of hCG (human chorionic gonadotropin) aloneObservational studySafety outcome

    In boys with cryptorchidism, spermatogonia per tubule values were normal only after surgery alone, rather than after pooled hormonal treatment (p = 0.06).

    In plain wordsIn boys with cryptorchidism, germ cell counts were normal only after surgery alone, not after hormone treatment (p = 0.06).

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    DecreaseNormal spermatogonia per tubule values
    Study

    n = 72

    Comparator
    Surgery alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    P value for normal spermatogonia per tubule values
    0.06 p value
    normal values only after surgery alone, as reported

    Source sentences

    Summary
    Spermatogonia per tubule values were normal only after surgery alone (p = 0.06).
    2 context sentences
    Summary · context
    We measured the number of spermatogonia per tubule at orchiopexy in 72 consecutive boys with cryptorchidism who underwent simultaneous testicular biopsy.
    Summary · context
    In 19 patients gonadotropin releasing hormone was unsuccessful, while 8 received HCG and 45 underwent orchiopexy without hormonal therapy.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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