Skip to content

Study · Animal study (in vivo) · holstein heifer · 2000

9 results

Effects of oxytocin on cloprostenol-induced luteolysis, follicular growth, ovulation and corpus luteum function in heifers.

Tallam SK, Walton JS, Johnson WH

Theriogenology1 Mar 2000Cited by 1 (Europe PMC)

PMID10730983 (opens in a new tab)DOI10.1016/s0093-691x(00)00243-0 (opens in a new tab)PepBankPUB-10730983
Publisher pagePubMedAsk about this study
Jump to 9 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Holstein heifers, daily progesterone before cloprostenol-induced luteolysis did not differ between oxytocin-infused and saline-infused groups.

    In plain wordsIn heifers, progesterone before induced luteal regression was not different with oxytocin infusion than with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeProgesterone before cloprostenol-induced luteolysis
    Study

    Holstein heifern: not reported in source

    cloprostenol-induced luteolysis
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1:9 mg/d · continuous infusion · Days 14 to 26 after estrusAs given in this study (Holstein heifer).

    Source sentences

    Summary
    Daily plasma progesterone (P4) concentrations prior to cloprostenol-induced luteolysis and rates of decline in P4 following the induced luteolysis did not differ between oxytocin-infused (OT-OT and OT-SC) and saline-infused (SC-SC and SC-OT) groups (P >0.1).
    3 context sentences
    Summary · context
    The SC-SC and SC-OT groups received continuous saline infusion, while Groups OT-SC and OT-OT received continuous oxytocin infusion (1:9 mg/d) on Days 14 to 26 after estrus.
    Summary · context
    Twenty-five normally cyclic Holstein heifers were used to examine the effects of oxytocin on cloprostenol-induced luteolysis, subsequent ovulation, and early luteal and follicular development.
    Summary · context
    The heifers were randomly assigned to 1 of 4 treatments: Group SC-SC (n=6), Group SC-OT (n=6), Group OT-SC (n=6) and Group OT-OT (n=7).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Holstein heifers, the rate of progesterone decline after induced luteolysis did not differ between oxytocin-infused and saline-infused groups.

    In plain wordsIn heifers, progesterone fell at the same rate after induced luteal regression with oxytocin infusion or saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeRate of progesterone decline after induced luteolysis
    Study

    Holstein heifern: not reported in source

    cloprostenol-induced luteolysis
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1:9 mg/d · continuous infusion · Days 14 to 26 after estrusAs given in this study (Holstein heifer).

    Source sentences

    Summary
    Daily plasma progesterone (P4) concentrations prior to cloprostenol-induced luteolysis and rates of decline in P4 following the induced luteolysis did not differ between oxytocin-infused (OT-OT and OT-SC) and saline-infused (SC-SC and SC-OT) groups (P >0.1).
    3 context sentences
    Summary · context
    The SC-SC and SC-OT groups received continuous saline infusion, while Groups OT-SC and OT-OT received continuous oxytocin infusion (1:9 mg/d) on Days 14 to 26 after estrus.
    Summary · context
    Twenty-five normally cyclic Holstein heifers were used to examine the effects of oxytocin on cloprostenol-induced luteolysis, subsequent ovulation, and early luteal and follicular development.
    Summary · context
    The heifers were randomly assigned to 1 of 4 treatments: Group SC-SC (n=6), Group SC-OT (n=6), Group OT-SC (n=6) and Group OT-OT (n=7).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In saline-infused Holstein heifers, daily oxytocin injections during the first week shortened the estrous cycle.

    In plain wordsIn heifers, oxytocin injections each day in the first week made the heat cycle shorter.

    Peptide
    Oxytocin
    Outcome
    DecreaseDuration of the estrous cycle after daily oxytocin injections
    Study

    Holstein heifern: not reported in source

    cloprostenol-induced luteolysis
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.33 USP units/kg body weight twice daily · subcutaneous · Days 3 to 6 of the estrous cycleAs given in this study (Holstein heifer).

    Source sentences

    Summary
    Duration of the estrous cycle was shortened in saline-infused heifers receiving oxytocin daily during the first week of the estrous cycle.
    3 context sentences
    Summary · context
    Groups SC-OT and OT-OT received oxytocin twice daily (12 h apart) (0.33 USP units/kg body weight, s.c.) on Days 3 to 6 of the estrous cycle following cloprostenol-induced luteolysis, while Groups SC-SC and OT-SC received an equivalent volume of saline.
    Summary · context
    Twenty-five normally cyclic Holstein heifers were used to examine the effects of oxytocin on cloprostenol-induced luteolysis, subsequent ovulation, and early luteal and follicular development.
    Summary · context
    The heifers were randomly assigned to 1 of 4 treatments: Group SC-SC (n=6), Group SC-OT (n=6), Group OT-SC (n=6) and Group OT-OT (n=7).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In Holstein heifers that received oxytocin infusion, oxytocin injections did not cause premature inhibition of luteal function and return to estrus.

    In plain wordsIn heifers that had oxytocin infusion, oxytocin injections did not end luteal function early or bring on heat early.

    Peptide
    Oxytocin
    Outcome
    No significant changeLuteal function and return to estrus after oxytocin infusion plus injections
    Study

    Holstein heifern: not reported in source

    cloprostenol-induced luteolysis
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Infusion 1:9 mg/d plus 0.33 USP units/kg body weight twice daily · continuous infusion and subcutaneous injection · Infusion Days 14 to 26; injections Days 3 to 6As given in this study (Holstein heifer).

    Source sentences

    Summary
    In contrast, oxytocin injections did not result in premature inhibition of luteal function and return to estrus in heifers that received oxytocin infusion (OT-OT).
    4 context sentences
    Summary · context
    The SC-SC and SC-OT groups received continuous saline infusion, while Groups OT-SC and OT-OT received continuous oxytocin infusion (1:9 mg/d) on Days 14 to 26 after estrus.
    Summary · context
    Groups SC-OT and OT-OT received oxytocin twice daily (12 h apart) (0.33 USP units/kg body weight, s.c.) on Days 3 to 6 of the estrous cycle following cloprostenol-induced luteolysis, while Groups SC-SC and OT-SC received an equivalent volume of saline.
    Summary · context
    Twenty-five normally cyclic Holstein heifers were used to examine the effects of oxytocin on cloprostenol-induced luteolysis, subsequent ovulation, and early luteal and follicular development.
    Summary · context
    The heifers were randomly assigned to 1 of 4 treatments: Group SC-SC (n=6), Group SC-OT (n=6), Group OT-SC (n=6) and Group OT-OT (n=7).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In Holstein heifers, the day of ovulation after cloprostenol did not differ between oxytocin-treated and saline-treated control heifers.

    In plain wordsIn heifers, ovulation happened on the same day with oxytocin treatment as with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeDay of ovulation
    Study

    Holstein heifern: not reported in source

    cloprostenol-induced luteolysis
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Day of ovulation, size of ovulating follicle and time of peak LH after cloprostenol administration for oxytocin and saline-treated control heifers did not differ (P >0.1).
    2 context sentences
    Summary · context
    Twenty-five normally cyclic Holstein heifers were used to examine the effects of oxytocin on cloprostenol-induced luteolysis, subsequent ovulation, and early luteal and follicular development.
    Summary · context
    The heifers were randomly assigned to 1 of 4 treatments: Group SC-SC (n=6), Group SC-OT (n=6), Group OT-SC (n=6) and Group OT-OT (n=7).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In Holstein heifers, the size of the ovulating follicle did not differ between oxytocin-treated and saline-treated control heifers.

    In plain wordsIn heifers, the follicle that ovulated was the same size with oxytocin treatment as with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeSize of the ovulating follicle
    Study

    Holstein heifern: not reported in source

    cloprostenol-induced luteolysis
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Day of ovulation, size of ovulating follicle and time of peak LH after cloprostenol administration for oxytocin and saline-treated control heifers did not differ (P >0.1).
    2 context sentences
    Summary · context
    Twenty-five normally cyclic Holstein heifers were used to examine the effects of oxytocin on cloprostenol-induced luteolysis, subsequent ovulation, and early luteal and follicular development.
    Summary · context
    The heifers were randomly assigned to 1 of 4 treatments: Group SC-SC (n=6), Group SC-OT (n=6), Group OT-SC (n=6) and Group OT-OT (n=7).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In Holstein heifers, the time of peak LH after cloprostenol did not differ between oxytocin-treated and saline-treated control heifers.

    In plain wordsIn heifers, the peak of LH hormone came at the same time with oxytocin treatment as with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeTime of peak LH after cloprostenol
    Study

    Holstein heifern: not reported in source

    cloprostenol-induced luteolysis
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Day of ovulation, size of ovulating follicle and time of peak LH after cloprostenol administration for oxytocin and saline-treated control heifers did not differ (P >0.1).
    2 context sentences
    Summary · context
    Twenty-five normally cyclic Holstein heifers were used to examine the effects of oxytocin on cloprostenol-induced luteolysis, subsequent ovulation, and early luteal and follicular development.
    Summary · context
    The heifers were randomly assigned to 1 of 4 treatments: Group SC-SC (n=6), Group SC-OT (n=6), Group OT-SC (n=6) and Group OT-OT (n=7).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In Holstein heifers, oxytocin-infused animals had fewer follicles of all classes during the first 3 days of the estrous cycle after luteal regression.

    In plain wordsIn heifers, oxytocin-infused animals had fewer follicles of all sizes in the first days after luteal regression.

    Peptide
    Oxytocin
    Outcome
    DecreaseNumber of follicles in first 3 days after luteal regression
    Study

    Holstein heifern: not reported in source

    cloprostenol-induced luteolysis
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1:9 mg/d · continuous infusion · Days 14 to 26 after estrusAs given in this study (Holstein heifer).

    Source sentences

    Summary
    During the first 3 d of the estrous cycle following luteal regression, fewer (P <0.01) follicles of all classes were observed in the oxytocin-infused animals.
    3 context sentences
    Summary · context
    The SC-SC and SC-OT groups received continuous saline infusion, while Groups OT-SC and OT-OT received continuous oxytocin infusion (1:9 mg/d) on Days 14 to 26 after estrus.
    Summary · context
    Twenty-five normally cyclic Holstein heifers were used to examine the effects of oxytocin on cloprostenol-induced luteolysis, subsequent ovulation, and early luteal and follicular development.
    Summary · context
    The heifers were randomly assigned to 1 of 4 treatments: Group SC-SC (n=6), Group SC-OT (n=6), Group OT-SC (n=6) and Group OT-OT (n=7).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In Holstein heifers, oxytocin treatment delayed the day of emergence of the first follicular wave.

    In plain wordsIn heifers, oxytocin treatment made the first wave of follicle growth start later.

    Peptide
    Oxytocin
    Outcome
    IncreaseDay of emergence of the first follicular wave
    Study

    Holstein heifern: not reported in source

    cloprostenol-induced luteolysis
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Day of emergence of the first follicular wave in heifers treated with oxytocin was delayed (P <0.05).
    2 context sentences
    Summary · context
    Twenty-five normally cyclic Holstein heifers were used to examine the effects of oxytocin on cloprostenol-induced luteolysis, subsequent ovulation, and early luteal and follicular development.
    Summary · context
    The heifers were randomly assigned to 1 of 4 treatments: Group SC-SC (n=6), Group SC-OT (n=6), Group OT-SC (n=6) and Group OT-OT (n=7).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.