Effects of oxytocin on follicular development and duration of the estrous cycle in heifers.

Tallam SK, Walton JS, Johnson WH

Theriogenology1 Mar 2000Cited by 9 (Europe PMC)

PMID10730982DOI10.1016/s0093-691x(00)00242-9PepBankPUB-10730982

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In Holstein heifers, three of four oxytocin-infused animals had an additional follicular wave, which control heifers did not have.
In plain wordsIn heifers, most oxytocin-infused animals had an extra wave of follicle growth, which controls did not have.
Peptide
Oxytocin
Outcome
IncreaseAdditional follicular wave
Study
Holstein heifern = 4
estrous cycle with luteolysis
Comparator
Saline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1.9 mg/d · continuous infusion · Days 14 to 26 after estrusAs given in this study (Holstein heifer).
Source sentences
Summary
Control heifers had 2 waves of follicular growth, with the second dominant follicle ovulating. Three of the 4 oxytocin-infused animals had an additional wave, with the third dominant follicle ovulating.
3 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers were used to study effects of exogenous administration of oxytocin on luteal function and ovarian follicular development.
Summary · context
At the subsequent estrus, these animals were randomly assigned to 1 of 3 treatments: saline control, (Group 1, n=4), oxytocin (Group 2, n=4) and saline pregnant (Group 3, n=4).
Summary · context
Group 2 received continuous infusion of oxytocin (1.9 mg/d) from Days 14 to 26 after estrus, while Groups 1 and 3 received saline infusion during the same period.
Report a problemFND-1073098205
02AnimalAnimal study (in vivo)Efficacy outcome
In Holstein heifers, continuous oxytocin infusion lengthened the interestrous interval.
In plain wordsIn heifers, a continuous oxytocin infusion made the time between heats longer.
Peptide
Oxytocin
Outcome
IncreaseInterestrous interval
Study
Holstein heifern: not reported in source
estrous cycle with luteolysis
Comparator
Saline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1.9 mg/d · continuous infusion · Days 14 to 26 after estrusAs given in this study (Holstein heifer).
Source sentences
Summary
The interestrous interval was longer (P <0.05) for heifers that received oxytocin infusion.
3 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers were used to study effects of exogenous administration of oxytocin on luteal function and ovarian follicular development.
Summary · context
At the subsequent estrus, these animals were randomly assigned to 1 of 3 treatments: saline control, (Group 1, n=4), oxytocin (Group 2, n=4) and saline pregnant (Group 3, n=4).
Summary · context
Group 2 received continuous infusion of oxytocin (1.9 mg/d) from Days 14 to 26 after estrus, while Groups 1 and 3 received saline infusion during the same period.
Report a problemFND-1073098201
03AnimalAnimal study (in vivo)Efficacy outcome
In Holstein heifers, plasma progesterone fell below 1 ng/mL on Day 19 in saline Group 1 but only on Day 28 in the oxytocin group.
In plain wordsIn heifers, progesterone dropped to very low levels later with oxytocin infusion than with saline.
Peptide
Oxytocin
Outcome
IncreaseDay plasma progesterone fell below 1 ng/mL
Study
Holstein heifern: not reported in source
estrous cycle with luteolysis
Comparator
Saline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1.9 mg/d · continuous infusion · Days 14 to 26 after estrusAs given in this study (Holstein heifer).
Measurements
Progesterone
< 1 ng/mL
Group 1, Day 19
Progesterone
< 1 ng/mL
Group 2 (oxytocin), Day 28
Source sentences
Summary
They then decreased to <1 ng/mL on Day 19 for Group 1 and on Day 28 for Group 2.
3 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers were used to study effects of exogenous administration of oxytocin on luteal function and ovarian follicular development.
Summary · context
At the subsequent estrus, these animals were randomly assigned to 1 of 3 treatments: saline control, (Group 1, n=4), oxytocin (Group 2, n=4) and saline pregnant (Group 3, n=4).
Summary · context
Group 2 received continuous infusion of oxytocin (1.9 mg/d) from Days 14 to 26 after estrus, while Groups 1 and 3 received saline infusion during the same period.
Report a problemFND-1073098202
04AnimalAnimal study (in vivo)Efficacy outcome
In Holstein heifers, plasma progesterone during oxytocin infusion did not differ from that of the saline pregnant group.
In plain wordsIn heifers, progesterone during oxytocin infusion was not different from the saline pregnant group.
Peptide
Oxytocin
Outcome
No significant changeProgesterone during infusion versus pregnant saline group
Study
Holstein heifern: not reported in source
estrous cycle with luteolysis
Comparator
Saline pregnant (Group 3)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1.9 mg/d · continuous infusion · Days 14 to 26 after estrusAs given in this study (Holstein heifer).
Source sentences
Summary
During the infusion period P4 concentrations were not different (P >0.05) between Group 2 and 3
3 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers were used to study effects of exogenous administration of oxytocin on luteal function and ovarian follicular development.
Summary · context
At the subsequent estrus, these animals were randomly assigned to 1 of 3 treatments: saline control, (Group 1, n=4), oxytocin (Group 2, n=4) and saline pregnant (Group 3, n=4).
Summary · context
Group 2 received continuous infusion of oxytocin (1.9 mg/d) from Days 14 to 26 after estrus, while Groups 1 and 3 received saline infusion during the same period.
Report a problemFND-1073098203
05AnimalAnimal study (in vivo)Efficacy outcome
In Holstein heifers receiving oxytocin, progesterone declined gradually from Day 20 despite high plasma oxytocin concentrations.
In plain wordsIn heifers, progesterone fell slowly from Day 20 during oxytocin infusion, even with high oxytocin in blood.
Peptide
Oxytocin
Outcome
DecreaseProgesterone decline from Day 20
Study
Holstein heifern: not reported in source
estrous cycle with luteolysis
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1.9 mg/d · continuous infusion · Days 14 to 26 after estrusAs given in this study (Holstein heifer).
Source sentences
Summary
declined gradually from Day 20 in Group 2 despite the presence of high plasma oxytocin concentrations.
3 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers were used to study effects of exogenous administration of oxytocin on luteal function and ovarian follicular development.
Summary · context
At the subsequent estrus, these animals were randomly assigned to 1 of 3 treatments: saline control, (Group 1, n=4), oxytocin (Group 2, n=4) and saline pregnant (Group 3, n=4).
Summary · context
Group 2 received continuous infusion of oxytocin (1.9 mg/d) from Days 14 to 26 after estrus, while Groups 1 and 3 received saline infusion during the same period.
Report a problemFND-1073098204
06AnimalAnimal study (in vivo)Efficacy outcome
In Holstein heifers, oxytocin infusion had no effect on the size of the ovulating follicle.
In plain wordsIn heifers, oxytocin infusion did not change the size of the follicle that ovulated.
Peptide
Oxytocin
Outcome
No significant changeSize of the ovulating follicle
Study
Holstein heifern: not reported in source
estrous cycle with luteolysis
Comparator
Saline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1.9 mg/d · continuous infusion · Days 14 to 26 after estrusAs given in this study (Holstein heifer).
Source sentences
Summary
Oxytocin infusion had no effect on size of the ovulating follicle (P >0.05) and the number of Class 1 follicles (3 to 5 mm, P >0.1).
3 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers were used to study effects of exogenous administration of oxytocin on luteal function and ovarian follicular development.
Summary · context
At the subsequent estrus, these animals were randomly assigned to 1 of 3 treatments: saline control, (Group 1, n=4), oxytocin (Group 2, n=4) and saline pregnant (Group 3, n=4).
Summary · context
Group 2 received continuous infusion of oxytocin (1.9 mg/d) from Days 14 to 26 after estrus, while Groups 1 and 3 received saline infusion during the same period.
Report a problemFND-1073098206
07AnimalAnimal study (in vivo)Efficacy outcome
In Holstein heifers, oxytocin infusion had no effect on the number of Class 1 follicles.
In plain wordsIn heifers, oxytocin infusion did not change the number of small follicles.
Peptide
Oxytocin
Outcome
No significant changeNumber of Class 1 follicles
Study
Holstein heifern: not reported in source
estrous cycle with luteolysis
Comparator
Saline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1.9 mg/d · continuous infusion · Days 14 to 26 after estrusAs given in this study (Holstein heifer).
Source sentences
Summary
Oxytocin infusion had no effect on size of the ovulating follicle (P >0.05) and the number of Class 1 follicles (3 to 5 mm, P >0.1).
3 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers were used to study effects of exogenous administration of oxytocin on luteal function and ovarian follicular development.
Summary · context
At the subsequent estrus, these animals were randomly assigned to 1 of 3 treatments: saline control, (Group 1, n=4), oxytocin (Group 2, n=4) and saline pregnant (Group 3, n=4).
Summary · context
Group 2 received continuous infusion of oxytocin (1.9 mg/d) from Days 14 to 26 after estrus, while Groups 1 and 3 received saline infusion during the same period.
Report a problemFND-1073098207
08AnimalAnimal study (in vivo)Efficacy outcome
In Holstein heifers, the number of Class 2 follicles did not differ among treatments on Days 15 to 22 after estrus.
In plain wordsIn heifers, the number of medium-size follicles did not differ between treatments in the first part of the infusion.
Peptide
Oxytocin
Outcome
No significant changeNumber of Class 2 follicles, Days 15 to 22
Study
Holstein heifern: not reported in source
estrous cycle with luteolysis
Comparator
Saline control and saline pregnant groups
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1.9 mg/d · continuous infusion · Days 14 to 26 after estrusAs given in this study (Holstein heifer).
Source sentences
Summary
Differences in the number of Class 2 follicles (6 to 9 mm) among treatments on Days 15 to 22 after estrus were not detected (P >0.1)
3 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers were used to study effects of exogenous administration of oxytocin on luteal function and ovarian follicular development.
Summary · context
At the subsequent estrus, these animals were randomly assigned to 1 of 3 treatments: saline control, (Group 1, n=4), oxytocin (Group 2, n=4) and saline pregnant (Group 3, n=4).
Summary · context
Group 2 received continuous infusion of oxytocin (1.9 mg/d) from Days 14 to 26 after estrus, while Groups 1 and 3 received saline infusion during the same period.
Report a problemFND-1073098208
09AnimalAnimal study (in vivo)Efficacy outcome
In Holstein heifers, oxytocin-infused animals had fewer Class 2 follicles than the saline pregnant group on Days 23 to 26.
In plain wordsIn heifers, oxytocin-infused animals had fewer medium-size follicles than the saline pregnant group late in the infusion.
Peptide
Oxytocin
Outcome
DecreaseNumber of Class 2 follicles, Days 23 to 26
Study
Holstein heifern: not reported in source
estrous cycle with luteolysis
Comparator
Saline pregnant (Group 3)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1.9 mg/d · continuous infusion · Days 14 to 26 after estrusAs given in this study (Holstein heifer).
Source sentences
Summary
Differences in the number of Class 2 follicles (6 to 9 mm) among treatments on Days 15 to 22 after estrus were not detected (P >0.1) except on Days 23 to 26, when Group 2 had fewer follicles than Group 3 (P <0.05).
3 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers were used to study effects of exogenous administration of oxytocin on luteal function and ovarian follicular development.
Summary · context
At the subsequent estrus, these animals were randomly assigned to 1 of 3 treatments: saline control, (Group 1, n=4), oxytocin (Group 2, n=4) and saline pregnant (Group 3, n=4).
Summary · context
Group 2 received continuous infusion of oxytocin (1.9 mg/d) from Days 14 to 26 after estrus, while Groups 1 and 3 received saline infusion during the same period.
Report a problemFND-1073098209

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.