A 6-day intracerebroventricular infusion of the growth hormone-releasing peptide KP-102 stimulates food intake in both non-stressed and intermittently-stressed rats.

Kuriyama H, Hotta M, Wakabayashi I, Shibasaki T

Neuroscience letters1 Mar 2000Cited by 17 (Europe PMC)

PMID10713408DOI10.1016/s0304-3940(00)00882-xPepBankPUB-10713408

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In free-feeding non-stressed rats, a 6-day i.c.v. infusion of KP-102 significantly increased food intake compared with saline.
In plain wordsIn rats, a 6-day brain infusion of KP-102 increased food intake compared with saline.
Peptide
GHRP-2
Outcome
IncreaseFood intake in non-stressed rats
Study
ratn: not reported in source
free-feeding non-stressed rats
Comparator
Saline i.c.v.
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 6 daysAs given in this study (rat).
Source sentences
Summary
A 6-day, i.c.v. infusion of KP-102 significantly and steadily increased food intake and body weight in free-feeding non-stressed rats compared to control rats receiving saline i.c.v.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of a 6-day intracerebroventricular (i.c.v.) infusion of KP-102, a growth hormone-releasing peptide (GHRP), on food intake and body weight gain were observed in free-feeding rats that were or were not subjected to intermittent electric footshock stress during the 6 days.
Report a problemFND-1071340801
02AnimalAnimal study (in vivo)Efficacy outcome
In free-feeding non-stressed rats, a 6-day i.c.v. infusion of KP-102 significantly increased body weight compared with saline.
In plain wordsIn rats, a 6-day brain infusion of KP-102 increased body weight compared with saline.
Peptide
GHRP-2
Outcome
IncreaseBody weight in non-stressed rats
Study
ratn: not reported in source
free-feeding non-stressed rats
Comparator
Saline i.c.v.
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 6 daysAs given in this study (rat).
Source sentences
Summary
A 6-day, i.c.v. infusion of KP-102 significantly and steadily increased food intake and body weight in free-feeding non-stressed rats compared to control rats receiving saline i.c.v.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of a 6-day intracerebroventricular (i.c.v.) infusion of KP-102, a growth hormone-releasing peptide (GHRP), on food intake and body weight gain were observed in free-feeding rats that were or were not subjected to intermittent electric footshock stress during the 6 days.
Report a problemFND-1071340802
03AnimalAnimal study (in vivo)Efficacy outcome
In rats exposed to intermittent footshock stress, KP-102 infusion stimulated feeding behavior compared with saline.
In plain wordsIn stressed rats, KP-102 infusion increased feeding compared with saline.
Peptide
GHRP-2
Outcome
IncreaseFeeding behavior in rats under intermittent footshock stress
Study
ratn: not reported in source
rats under intermittent footshock stress
Comparator
Saline i.c.v.
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 6 daysAs given in this study (rat).
Source sentences
Summary
In rats exposed to intermittent footshock stress during the 6-day infusion, KP-102 treatment stimulated feeding behavior and resulted in significantly higher body weight compared to stressed rats that received i.c.v. infusion of saline.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of a 6-day intracerebroventricular (i.c.v.) infusion of KP-102, a growth hormone-releasing peptide (GHRP), on food intake and body weight gain were observed in free-feeding rats that were or were not subjected to intermittent electric footshock stress during the 6 days.
Report a problemFND-1071340803
04AnimalAnimal study (in vivo)Efficacy outcome
In rats exposed to intermittent footshock stress, KP-102 infusion resulted in significantly higher body weight than saline.
In plain wordsIn stressed rats, KP-102 infusion led to higher body weight than saline.
Peptide
GHRP-2
Outcome
IncreaseBody weight in rats under intermittent footshock stress
Study
ratn: not reported in source
rats under intermittent footshock stress
Comparator
Saline i.c.v.
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 6 daysAs given in this study (rat).
Source sentences
Summary
In rats exposed to intermittent footshock stress during the 6-day infusion, KP-102 treatment stimulated feeding behavior and resulted in significantly higher body weight compared to stressed rats that received i.c.v. infusion of saline.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of a 6-day intracerebroventricular (i.c.v.) infusion of KP-102, a growth hormone-releasing peptide (GHRP), on food intake and body weight gain were observed in free-feeding rats that were or were not subjected to intermittent electric footshock stress during the 6 days.
Report a problemFND-1071340804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.