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Study · Animal study (in vivo) · rat · 2000

4 results

Oxytocin induces preservation of social recognition in male rats by activating alpha-adrenoceptors of the olfactory bulb.

Dluzen DE, Muraoka S, Engelmann M, Ebner K, Landgraf R

The European journal of neuroscience1 Feb 2000Cited by 73 (Europe PMC)

PMID10712656 (opens in a new tab)DOI10.1046/j.1460-9568.2000.00952.x (opens in a new tab)PepBankPUB-10712656
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, oxytocin infused into the olfactory bulb preserved social recognition.

    In plain wordsIn male rats, oxytocin infused into the smell centre of the brain preserved social memory.

    Peptide
    Oxytocin
    Outcome
    IncreasePreservation of social recognition
    Study

    ratn: not reported in source

    male rat olfactory bulb
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intra-olfactory bulb infusionAs given in this study (rat).

    Source sentences

    Summary
    The present data indicate that oxytocin exerts this preservation of social recognition through a specific, receptor-mediated mechanism within the olfactory bulb (experiment 1).
    1 context sentence
    Summary · context
    In this report, a series of four experiments was performed to evaluate the relationship between the olfactory bulb norepinephrine system and intra-olfactory bulb infusion of oxytocin in the preservation of social memory responses.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male rats, preservation of social recognition by oxytocin occurs through a specific, receptor-mediated mechanism within the olfactory bulb.

    In plain wordsIn male rats, oxytocin acted through its receptor in the olfactory bulb to preserve social memory.

    Peptide
    Oxytocin
    Outcome
    Not applicableReceptor-mediated mechanism in the olfactory bulb
    Study

    ratn: not reported in source

    male rat olfactory bulb
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intra-olfactory bulb infusionAs given in this study (rat).

    Source sentences

    Summary
    The present data indicate that oxytocin exerts this preservation of social recognition through a specific, receptor-mediated mechanism within the olfactory bulb (experiment 1).
    1 context sentence
    Summary · context
    In this report, a series of four experiments was performed to evaluate the relationship between the olfactory bulb norepinephrine system and intra-olfactory bulb infusion of oxytocin in the preservation of social memory responses.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In male rats, retrodialysis of oxytocin into the olfactory bulb increased norepinephrine release.

    In plain wordsIn male rats, oxytocin given into the olfactory bulb increased release of norepinephrine.

    Peptide
    Oxytocin
    Outcome
    IncreaseOlfactory bulb norepinephrine release
    Study

    ratn: not reported in source

    male rat olfactory bulb
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · retrodialysisAs given in this study (rat).

    Source sentences

    Summary
    The involvement of the olfactory bulb norepinephrine system is revealed by the demonstration that retrodialysis of oxytocin into the olfactory bulb increases norepinephrine release (experiment 4).
    1 context sentence
    Summary · context
    In this report, a series of four experiments was performed to evaluate the relationship between the olfactory bulb norepinephrine system and intra-olfactory bulb infusion of oxytocin in the preservation of social memory responses.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In male rats, co-infusion of oxytocin with phentolamine abolished recognition responses.

    In plain wordsIn male rats, giving phentolamine together with oxytocin removed the social recognition responses.

    Peptide
    Oxytocin
    Outcome
    DecreaseRecognition responses with oxytocin and phentolamine co-infusion
    Study

    ratn: not reported in source

    male rat olfactory bulb
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    In addition, a co-infusion of oxytocin with phentolamine abolishes recognition responses (experiment 3).
    1 context sentence
    Summary · context
    In this report, a series of four experiments was performed to evaluate the relationship between the olfactory bulb norepinephrine system and intra-olfactory bulb infusion of oxytocin in the preservation of social memory responses.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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