In CHO cells, several melanocortin peptides including MT-II were more than 10-fold more potent at the rhesus than at the human melanocortin-5 receptor.
In plain wordsIn cells, several peptides, including melanotan II, were over 10 times more potent at the monkey receptor than at the human receptor.
- Peptide
- Melanotan II
- Outcome
- Not applicablePotency at rhesus versus human melanocortin-5 receptor
- Study
rhesus monkey and humann: not reported in source
CHO cells expressing rhesus or human melanocortin-5 receptor- Outcome group
- Receptor activity and mechanism · Pharmacology
Measurements
- Potency ratio, rhesus versus human MC5R
- > 10 fold
- several peptides including MT-II
Source sentences
Several peptides including NDP-alpha-MSH, alpha-MSH, MT-II and ACTH1-24 are more potent at the rhesus melanocortin-5 receptor than the human melanocortin-5 receptor by more than 10-fold.
1 context sentence(design, population, supporting numbers)
Heterologous expression in CHO cells indicated species dependent in vitro pharmacological properties for the human and rhesus melanocortin-5 receptors.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.