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Study · Animal study (in vivo) · rat · 1999

7 results

[Changes in the enzyme activity in the brain structures of August rats under the influence of the delta sleep-inducing peptide against a background of prolonged L-dihydroxyphenylalanine administration].

Sergutina AV, Rakhmanova VI

Morfologiia (Saint Petersburg, Russia)1 Jan 1999

PMID10709190 (opens in a new tab)PepBankPUB-10709190
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In August rats predisposed to emotional stress, DSIP decreased MAO activity (tryptamine substrate) in the hippocampus.

    In plain wordsIn rats prone to stress, DSIP lowered the activity of the enzyme MAO in the hippocampus.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseMAO activity (tryptamine) in hippocampus
    Study

    ratn: not reported in source

    August rats predisposed to emotional stress with prolonged L-DOPA treatment
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Quantitative cytochemical methods revealed the decrease of MAO activity (substrate--tryptamine) in the hippocampus of L-dioxytryptamine treated August rats genetically predisposed to emotional stress under the effect of delta sleep inducing peptide (DSIP).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In August rats predisposed to emotional stress, DSIP decreased aminopeptidase activity in the nucleus accumbens.

    In plain wordsIn rats prone to stress, DSIP lowered the activity of the enzyme aminopeptidase in the nucleus accumbens.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseAminopeptidase activity in nucleus accumbens
    Study

    ratn: not reported in source

    August rats predisposed to emotional stress with prolonged L-DOPA treatment
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Activities of aminopeptidase and glutamate dehydrogenase were decreased in n.accumbens
  3. 03AnimalAnimal study (in vivo)Mechanism

    In August rats predisposed to emotional stress, DSIP decreased glutamate dehydrogenase activity in the nucleus accumbens.

    In plain wordsIn rats prone to stress, DSIP lowered the activity of the enzyme glutamate dehydrogenase in the nucleus accumbens.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseGlutamate dehydrogenase activity in nucleus accumbens
    Study

    ratn: not reported in source

    August rats predisposed to emotional stress with prolonged L-DOPA treatment
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Activities of aminopeptidase and glutamate dehydrogenase were decreased in n.accumbens
  4. 04AnimalAnimal study (in vivo)Mechanism

    In August rats predisposed to emotional stress, DSIP changed aminopeptidase activity in cortex layers III and V and the caudate nucleus not significantly.

    In plain wordsIn rats prone to stress, DSIP did not significantly change aminopeptidase activity in the cortex and caudate nucleus.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeAminopeptidase activity in sensomotor cortex and caudate nucleus
    Study

    ratn: not reported in source

    August rats predisposed to emotional stress with prolonged L-DOPA treatment
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while changes of the activities of these enzymes were not significant in the layers III and V of sensomotor cortex and n.caudatus.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In August rats predisposed to emotional stress, DSIP changed glutamate dehydrogenase activity in cortex layers III and V and the caudate nucleus not significantly.

    In plain wordsIn rats prone to stress, DSIP did not significantly change glutamate dehydrogenase activity in the cortex and caudate nucleus.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeGlutamate dehydrogenase activity in sensomotor cortex and caudate nucleus
    Study

    ratn: not reported in source

    August rats predisposed to emotional stress with prolonged L-DOPA treatment
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while changes of the activities of these enzymes were not significant in the layers III and V of sensomotor cortex and n.caudatus.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In August rats predisposed to emotional stress, DSIP did not influence AChE activity in any brain structure studied.

    In plain wordsIn rats prone to stress, DSIP did not change acetylcholinesterase activity in the brain areas studied.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeAcetylcholinesterase activity in all brain structures
    Study

    ratn: not reported in source

    August rats predisposed to emotional stress with prolonged L-DOPA treatment
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In all brain structures Ache and MAO (substrate 5-hydroxytryptamine) activities were not influenced by DSIP
  7. 07AnimalAnimal study (in vivo)Mechanism

    In August rats predisposed to emotional stress, DSIP did not influence MAO activity (5-hydroxytryptamine substrate) in any brain structure studied.

    In plain wordsIn rats prone to stress, DSIP did not change MAO activity with the 5-hydroxytryptamine substrate in the brain areas studied.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeMAO activity (5-hydroxytryptamine) in all brain structures
    Study

    ratn: not reported in source

    August rats predisposed to emotional stress with prolonged L-DOPA treatment
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In all brain structures Ache and MAO (substrate 5-hydroxytryptamine) activities were not influenced by DSIP

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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