Local arterial vasoconstriction induced by octreotide in patients with cirrhosis.

Chatila R, Ferayorni L, Gupta T, Groszmann RJ

Hepatology (Baltimore, Md.)1 Mar 2000Cited by 45 (Europe PMC)

PMID10706544DOI10.1002/hep.510310304PepBankPUB-10706544

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanNon-randomized trialEfficacy outcome
In cirrhotic patients, intra-arterial octreotide reduced infused-arm forearm blood flow by 34% +/- 7.7 versus preceding saline (P <.005).
In plain wordsIn cirrhotic patients, octreotide reduced blood flow in the infused forearm by 34% compared with preceding saline.
Peptide
Octreotide
Outcome
DecreaseInfused forearm blood flow
Study
n = 10
Comparator
Preceding saline infusion
Outcome group
Vascular function · Cardiovascular
Studied dose
20 microg/h · intra-arterial · 5 minutesAs given in this study (human).
Measurements
Forearm blood flow reduction
34%
infused arm, octreotide 20 microg/h versus preceding saline
Forearm blood flow reduction, +/- value
7.7%
infused arm, octreotide 20 microg/h versus preceding saline
Source sentences
Summary
Saline infusion did not alter FBF, but octreotide infusion resulted in a 34% +/- 7.7 (P <.005) reduction in FBF in the infused arm.
3 context sentences(design, population, supporting numbers)
Summary · context
FBF was measured in 10 cirrhotic patients by venous occlusion plethysmography.
Summary · context
Each infusion, lasting 5 minutes, was followed by saline for washout.
Summary · context
Percent change in flow (%triangle up) was obtained by comparing the flow during drug administration to that during the preceding saline infusion.
Report a problemFND-1070654401
02HumanNon-randomized trialEfficacy outcome
In cirrhotic patients receiving local octreotide, blood flow in the uninfused control arm remained unchanged.
In plain wordsIn cirrhotic patients receiving local octreotide, blood flow in the other arm did not change compared with preceding saline.
Peptide
Octreotide
Outcome
No significant changeUninfused forearm blood flow
Study
n = 10
Comparator
Preceding saline infusion
Outcome group
Vascular function · Cardiovascular
Studied dose
20 microg/h · intra-arterial · 5 minutesAs given in this study (human).
Source sentences
Summary
FBF in the control arm was unchanged despite a significant decrease in systemic glucagon levels.
3 context sentences(design, population, supporting numbers)
Summary · context
FBF was measured in 10 cirrhotic patients by venous occlusion plethysmography.
Summary · context
Each infusion, lasting 5 minutes, was followed by saline for washout.
Summary · context
Percent change in flow (%triangle up) was obtained by comparing the flow during drug administration to that during the preceding saline infusion.
Report a problemFND-1070654402
03HumanNon-randomized trialMechanism
In cirrhotic patients, local octreotide infusion significantly decreased systemic glucagon levels.
In plain wordsIn cirrhotic patients, local octreotide infusion lowered blood glucagon levels from baseline.
Peptide
Octreotide
Outcome
DecreaseSystemic glucagon levels
Study
n = 10
Comparator
Baseline
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
20 microg/h · intra-arterial · 5 minutesAs given in this study (human).
Source sentences
Summary
FBF in the control arm was unchanged despite a significant decrease in systemic glucagon levels.
3 context sentences(design, population, supporting numbers)
Summary · context
FBF was measured in 10 cirrhotic patients by venous occlusion plethysmography.
Summary · context
Each infusion, lasting 5 minutes, was followed by saline for washout.
Summary · context
Percent change in flow (%triangle up) was obtained by comparing the flow during drug administration to that during the preceding saline infusion.
Report a problemFND-1070654403
04HumanNon-randomized trialEfficacy outcome
In cirrhotic patients, adding octreotide did not alter the approximately 300% forearm blood flow increase induced by methacholine.
In plain wordsIn cirrhotic patients, adding octreotide did not change the blood flow increase caused by methacholine alone.
Peptide
Octreotide
Outcome
No significant changeMethacholine-stimulated forearm blood flow
Study
n = 10
Comparator
Methacholine alone
Outcome group
Vascular function · Cardiovascular
Studied dose
20 microg/h · intra-arterial · 5 minutesAs given in this study (human).
Measurements
Methacholine-induced forearm blood flow increase
≈ 300%
methacholine alone and with concomitant octreotide
Source sentences
Summary
Methacholine infusion increased FBF around 300%, which was not altered by the concomitant infusion of octreotide.
3 context sentences(design, population, supporting numbers)
Summary · context
FBF was measured in 10 cirrhotic patients by venous occlusion plethysmography.
Summary · context
Each infusion, lasting 5 minutes, was followed by saline for washout.
Summary · context
Percent change in flow (%triangle up) was obtained by comparing the flow during drug administration to that during the preceding saline infusion.
Report a problemFND-1070654404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

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