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Study · Animal study (in vivo) · rabbit · 2000

4 results

Inhibition of chondrogenesis by parathyroid hormone in vivo during repair of full-thickness defects of articular cartilage.

Kudo S, Mizuta H, Otsuka Y, Takagi K, Hiraki Y

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 Feb 2000Cited by 18 (Europe PMC)

PMID10703926 (opens in a new tab)DOI10.1359/jbmr.2000.15.2.253 (opens in a new tab)PepBankPUB-10703926
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rabbit cartilage defects, hPTH(1-84) prevented observed chondrogenic differentiation throughout the experimental period versus saline.

    In plain wordsIn rabbits, hPTH(1-84) prevented cartilage cell development in defects compared with saline.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    DecreaseChondrogenic differentiation
    Study

    rabbitn: not reported in source

    full-thickness articular cartilage defects
    Comparator
    saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25 ng/h · joint cavity infusionAs given in this study (rabbit).

    Source sentences

    Summary
    In contrast, no evidence of chondrogenic differentiation was seen at any time during the experimental period in the defects treated with PTH.
    1 context sentence
    Summary · context
    Recombinant human PTH(1-84) (hPTH[1-84]) (25 ng/h) then was administered into the joint cavity with an osmotic pump, or in control animals, saline alone was administered.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rabbit cartilage defects, PTH did not interfere with reparative cell proliferation.

    In plain wordsIn rabbits, PTH did not interfere with repair cell multiplication compared with saline.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeCell proliferation
    Study

    rabbitn: not reported in source

    full-thickness articular cartilage defects
    Comparator
    saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25 ng/h · joint cavity infusionAs given in this study (rabbit).

    Source sentences

    Summary
    Application of PTH did not interfere with proliferation but inhibited chondrogenic differentiation of the cells resulting in the formation of fibrous tissue that lost the expression of PTH/PTHrP receptor within 4 weeks.
    1 context sentence
    Summary · context
    Recombinant human PTH(1-84) (hPTH[1-84]) (25 ng/h) then was administered into the joint cavity with an osmotic pump, or in control animals, saline alone was administered.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rabbit cartilage defects, PTH inhibited chondrogenic differentiation and produced fibrous repair tissue.

    In plain wordsIn rabbits, PTH inhibited cartilage cell development and produced fibrous repair tissue compared with saline.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    Not applicableFibrous repair tissue formation
    Study

    rabbitn: not reported in source

    full-thickness articular cartilage defects
    Comparator
    saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25 ng/h · joint cavity infusionAs given in this study (rabbit).

    Source sentences

    Summary
    Application of PTH did not interfere with proliferation but inhibited chondrogenic differentiation of the cells resulting in the formation of fibrous tissue that lost the expression of PTH/PTHrP receptor within 4 weeks.
    1 context sentence
    Summary · context
    Recombinant human PTH(1-84) (hPTH[1-84]) (25 ng/h) then was administered into the joint cavity with an osmotic pump, or in control animals, saline alone was administered.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rabbit cartilage defects treated with PTH, fibrous repair tissue lost PTH/PTHrP receptor expression within 4 weeks.

    In plain wordsIn rabbits given PTH, fibrous repair tissue lost its PTH/PTHrP receptor signal within 4 weeks.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    DecreasePTH/PTHrP receptor expression in repair tissue
    Study

    rabbitn: not reported in source

    full-thickness articular cartilage defects
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25 ng/h · joint cavity infusionAs given in this study (rabbit).

    Source sentences

    Summary
    Application of PTH did not interfere with proliferation but inhibited chondrogenic differentiation of the cells resulting in the formation of fibrous tissue that lost the expression of PTH/PTHrP receptor within 4 weeks.
    1 context sentence
    Summary · context
    Recombinant human PTH(1-84) (hPTH[1-84]) (25 ng/h) then was administered into the joint cavity with an osmotic pump, or in control animals, saline alone was administered.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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