Parathyroid hormone (1-34) increases the density of rat cancellous bone in a bone chamber. A dose-response study.

Skripitz R, Andreassen TT, Aspenberg P

The Journal of bone and joint surgery. British volume1 Jan 2000Cited by 55 (Europe PMC)

PMID10697330DOI10.1302/0301-620x.82b1.9729PepBankPUB-10697330

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with bone chambers, PTH did not change ingrowth distance compared with no PTH.
In plain wordsIn rats, PTH did not change bone chamber ingrowth distance compared with no PTH.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeIngrowth distance
Study
ratn = 40
Male rats with implanted tibial titanium bone chamber
Comparator
No PTH
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15, 60, or 240 microg/kg/day · Injection · 42 daysAs given in this study (rat).
Source sentences
Summary
During the observation period the chamber became only partly filled with callus and bone and no difference in ingrowth distance into the chamber was found between the groups.
1 context sentence(design, population, supporting numbers)
Summary · context
We have investigated the spontaneous ingrowth of callus and the formation of bone in a titanium chamber implanted at the medioproximal aspect of the tibial metaphysis of the rat. Four groups of ten male rats weighing approximately 350 g were injected with human PTH (1-34) in a dosage of 0, 15, 60 or…
Report a problemFND-1069733001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with bone chambers, PTH increased cancellous density by 90% compared with no PTH.
In plain wordsIn rats, PTH increased bone chamber cancellous density compared with no PTH.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCancellous density
Study
ratn = 20
Male rats with implanted tibial titanium bone chamber
Comparator
No PTH
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 microg/kg/day · Injection · 42 daysAs given in this study (rat).
Measurements
Density increase
90%
15 microg/kg/day
Source sentences
Summary
The cancellous density was increased by 90%, 132% and 173% in the groups given PTH in a dosage of 15, 60 or 240 microg/kg/day, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
We have investigated the spontaneous ingrowth of callus and the formation of bone in a titanium chamber implanted at the medioproximal aspect of the tibial metaphysis of the rat. Four groups of ten male rats weighing approximately 350 g were injected with human PTH (1-34) in a dosage of 0, 15, 60 or…
Report a problemFND-1069733002
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with bone chambers, PTH increased cancellous density by 132% compared with no PTH.
In plain wordsIn rats, PTH increased bone chamber cancellous density compared with no PTH.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCancellous density
Study
ratn = 20
Male rats with implanted tibial titanium bone chamber
Comparator
No PTH
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg/day · Injection · 42 daysAs given in this study (rat).
Measurements
Density increase
132%
60 microg/kg/day
Source sentences
Summary
The cancellous density was increased by 90%, 132% and 173% in the groups given PTH in a dosage of 15, 60 or 240 microg/kg/day, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
We have investigated the spontaneous ingrowth of callus and the formation of bone in a titanium chamber implanted at the medioproximal aspect of the tibial metaphysis of the rat. Four groups of ten male rats weighing approximately 350 g were injected with human PTH (1-34) in a dosage of 0, 15, 60 or…
Report a problemFND-1069733003
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with bone chambers, PTH increased cancellous density by 173% compared with no PTH.
In plain wordsIn rats, PTH increased bone chamber cancellous density compared with no PTH.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCancellous density
Study
ratn = 20
Male rats with implanted tibial titanium bone chamber
Comparator
No PTH
Outcome group
Bone and joint · Musculoskeletal
Studied dose
240 microg/kg/day · Injection · 42 daysAs given in this study (rat).
Measurements
Density increase
173%
240 microg/kg/day
Source sentences
Summary
The cancellous density was increased by 90%, 132% and 173% in the groups given PTH in a dosage of 15, 60 or 240 microg/kg/day, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
We have investigated the spontaneous ingrowth of callus and the formation of bone in a titanium chamber implanted at the medioproximal aspect of the tibial metaphysis of the rat. Four groups of ten male rats weighing approximately 350 g were injected with human PTH (1-34) in a dosage of 0, 15, 60 or…
Report a problemFND-1069733004
05AnimalAnimal study (in vivo)Mechanism
In rats with bone chambers, bone density correlated linearly with log PTH dose.
In plain wordsIn rats, bone density correlated with log PTH dose.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseDensity-dose correlation
Study
ratn: not reported in source
Male rats with implanted tibial titanium bone chamber
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15, 60, or 240 microg/kg/day · Injection · 42 daysAs given in this study (rat).
Measurements
r squared
0.6 unitless
density versus log dose
Source sentences
Summary
There was a linear correlation between bone density and the log PTH doses (r 2= 0.6).
1 context sentence(design, population, supporting numbers)
Summary · context
We have investigated the spontaneous ingrowth of callus and the formation of bone in a titanium chamber implanted at the medioproximal aspect of the tibial metaphysis of the rat. Four groups of ten male rats weighing approximately 350 g were injected with human PTH (1-34) in a dosage of 0, 15, 60 or…
Report a problemFND-1069733005

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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