Effects of oxytocin and vasopressin on sperm transport from the cauda epididymis in sheep.

Nicholson HD, Parkinson TJ, Lapwood KR

Journal of reproduction and fertility1 Nov 1999Cited by 36 (Europe PMC)

PMID10690197DOI10.1530/jrf.0.1170299PepBankPUB-10690197

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rams, oxytocin 10 micrograms increased the output of epididymal fluid.
In plain wordsIn rams, a small oxytocin dose increased the amount of fluid leaving the epididymis.
Peptide
Oxytocin
Outcome
IncreaseEpididymal fluid output after oxytocin 10 micrograms
Study
sheepn: not reported in source
Anaesthetised rams with cannulae in the cauda epididymis
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 micrograms · intravenousAs given in this study (sheep).
Source sentences
Summary
Oxytocin at 10 micrograms significantly increased both the output of fluid and the number of spermatozoa by twofold.
1 context sentence(design, population, supporting numbers)
Summary · context
Under general anaesthesia, cannulae were inserted into each ductus deferens and passed into the cauda epididymis of 24 Oxford Down cross rams and the luminal fluid was collected at 10 min intervals for 2-3 h.
Report a problemFND-1069019701
02AnimalAnimal study (in vivo)Efficacy outcome
In rams, oxytocin 10 micrograms increased the number of spermatozoa in epididymal fluid twofold.
In plain wordsIn rams, a small oxytocin dose doubled the number of sperm in epididymal fluid.
Peptide
Oxytocin
Outcome
IncreaseSperm number after oxytocin 10 micrograms
Study
sheepn: not reported in source
Anaesthetised rams with cannulae in the cauda epididymis
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 micrograms · intravenousAs given in this study (sheep).
Source sentences
Summary
Oxytocin at 10 micrograms significantly increased both the output of fluid and the number of spermatozoa by twofold.
1 context sentence(design, population, supporting numbers)
Summary · context
Under general anaesthesia, cannulae were inserted into each ductus deferens and passed into the cauda epididymis of 24 Oxford Down cross rams and the luminal fluid was collected at 10 min intervals for 2-3 h.
Report a problemFND-1069019702
03AnimalAnimal study (in vivo)Efficacy outcome
In rams, oxytocin 100 micrograms produced a greater increase in epididymal fluid output than the lower dose, within 10 min.
In plain wordsIn rams, a larger oxytocin dose raised epididymal fluid output more than the smaller dose, within 10 minutes.
Peptide
Oxytocin
Outcome
IncreaseEpididymal fluid output after oxytocin 100 micrograms
Study
sheepn: not reported in source
Anaesthetised rams with cannulae in the cauda epididymis
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 micrograms · intravenousAs given in this study (sheep).
Source sentences
Summary
Oxytocin at 100 micrograms produced a greater increase in both fluid output and the number of spermatozoa within 10 min of administration of the peptide.
1 context sentence(design, population, supporting numbers)
Summary · context
Under general anaesthesia, cannulae were inserted into each ductus deferens and passed into the cauda epididymis of 24 Oxford Down cross rams and the luminal fluid was collected at 10 min intervals for 2-3 h.
Report a problemFND-1069019703
04AnimalAnimal study (in vivo)Efficacy outcome
In rams, oxytocin 100 micrograms produced a greater increase in the number of spermatozoa than the lower dose, within 10 min.
In plain wordsIn rams, a larger oxytocin dose raised sperm numbers in epididymal fluid more than the smaller dose, within 10 minutes.
Peptide
Oxytocin
Outcome
IncreaseSperm number after oxytocin 100 micrograms
Study
sheepn: not reported in source
Anaesthetised rams with cannulae in the cauda epididymis
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 micrograms · intravenousAs given in this study (sheep).
Source sentences
Summary
Oxytocin at 100 micrograms produced a greater increase in both fluid output and the number of spermatozoa within 10 min of administration of the peptide.
1 context sentence(design, population, supporting numbers)
Summary · context
Under general anaesthesia, cannulae were inserted into each ductus deferens and passed into the cauda epididymis of 24 Oxford Down cross rams and the luminal fluid was collected at 10 min intervals for 2-3 h.
Report a problemFND-1069019704
05AnimalAnimal study (in vivo)Efficacy outcome
In rams, no significant change in the morphology of spermatozoa was observed in any of the collected samples.
In plain wordsIn rams, sperm shape did not change significantly in any sample.
Peptide
Oxytocin
Outcome
No significant changeSperm morphology
Study
sheepn: not reported in source
Anaesthetised rams with cannulae in the cauda epididymis
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intravenousAs given in this study (sheep).
Source sentences
Summary
No significant changes in the morphology or motility of the spermatozoa collected was observed in any of the samples.
1 context sentence(design, population, supporting numbers)
Summary · context
Under general anaesthesia, cannulae were inserted into each ductus deferens and passed into the cauda epididymis of 24 Oxford Down cross rams and the luminal fluid was collected at 10 min intervals for 2-3 h.
Report a problemFND-1069019705
06AnimalAnimal study (in vivo)Efficacy outcome
In rams, no significant change in the motility of spermatozoa was observed in any of the collected samples.
In plain wordsIn rams, sperm movement did not change significantly in any sample.
Peptide
Oxytocin
Outcome
No significant changeSperm motility
Study
sheepn: not reported in source
Anaesthetised rams with cannulae in the cauda epididymis
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intravenousAs given in this study (sheep).
Source sentences
Summary
No significant changes in the morphology or motility of the spermatozoa collected was observed in any of the samples.
1 context sentence(design, population, supporting numbers)
Summary · context
Under general anaesthesia, cannulae were inserted into each ductus deferens and passed into the cauda epididymis of 24 Oxford Down cross rams and the luminal fluid was collected at 10 min intervals for 2-3 h.
Report a problemFND-1069019706

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

07AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In rams, pretreatment with an oxytocin antagonist inhibited the stimulatory effect of oxytocin.
In plain wordsIn rams, an oxytocin blocker given first stopped the increase that oxytocin normally caused.
Peptide
Oxytocin
Outcome
DecreaseOxytocin antagonist pretreatment on oxytocin effect
Study
sheepn: not reported in source
Anaesthetised rams with cannulae in the cauda epididymis
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Pretreatment with oxytocin antagonist inhibited the stimulatory effect of oxytocin.
1 context sentence(design, population, supporting numbers)
Summary · context
Under general anaesthesia, cannulae were inserted into each ductus deferens and passed into the cauda epididymis of 24 Oxford Down cross rams and the luminal fluid was collected at 10 min intervals for 2-3 h.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1069019707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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