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Study · Animal study (in vivo) · sheep · 2000

6 results

Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection.

Charman SA, Segrave AM, Edwards GA, Porter CJ

Journal of pharmaceutical sciences1 Feb 2000Cited by 65 (Europe PMC)

PMID10688746 (opens in a new tab)DOI10.1002/(sici)1520-6017(200002)89:2<168::aid-jps4>3.0.co;2-q (opens in a new tab)PepBankPUB-10688746
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In sheep without lymph cannulation, subcutaneous hGH availability was 58.4 +/- 9.1% relative to intravenous hGH.

    In plain wordsIn sheep without lymph cannulation, subcutaneous hGH availability was 58.4 +/- 9.1% relative to intravenous hGH.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseSystemic availability without lymph cannulation
    Study

    Sheepn: not reported in source

    Lymphatic transport model
    Comparator
    Intravenous hGH
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · SubcutaneousAs given in this study (Sheep).

    Source sentences

    Summary
    In non-lymph cannulated sheep, the systemic availability of hGH following SC dosing was 58.4 +/- 9.1% (mean +/- SEM) relative to an intravenous (IV) control.
    1 context sentence
    Summary · context
    The animal model utilized a sheep and enabled simultaneous sampling of blood and collection of either peripheral lymph (via the efferent duct of the popliteal lymph node draining the injection site) or central lymph (via the thoracic lymph duct).
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In sheep, hGH availability decreased to approximately 30-40% during peripheral lymph collection.

    In plain wordsIn sheep, hGH availability decreased to approximately 30-40% during peripheral lymph collection compared with no lymph collection.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseAvailability during peripheral lymph collection
    Study

    Sheepn: not reported in source

    Lymphatic transport model
    Comparator
    Non-lymph cannulated sheep
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · SubcutaneousAs given in this study (Sheep).

    Source sentences

    Summary
    The availability of hGH decreased to approximately 30-40% when either peripheral or central lymph was collected indicating that a proportion of the dose was transported via the lymph.
    1 context sentence
    Summary · context
    The animal model utilized a sheep and enabled simultaneous sampling of blood and collection of either peripheral lymph (via the efferent duct of the popliteal lymph node draining the injection site) or central lymph (via the thoracic lymph duct).
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In sheep, hGH availability decreased to approximately 30-40% during central lymph collection.

    In plain wordsIn sheep, hGH availability decreased to approximately 30-40% during central lymph collection compared with no lymph collection.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseAvailability during central lymph collection
    Study

    Sheepn: not reported in source

    Lymphatic transport model
    Comparator
    Non-lymph cannulated sheep
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · SubcutaneousAs given in this study (Sheep).

    Source sentences

    Summary
    The availability of hGH decreased to approximately 30-40% when either peripheral or central lymph was collected indicating that a proportion of the dose was transported via the lymph.
    1 context sentence
    Summary · context
    The animal model utilized a sheep and enabled simultaneous sampling of blood and collection of either peripheral lymph (via the efferent duct of the popliteal lymph node draining the injection site) or central lymph (via the thoracic lymph duct).
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In sheep, peripheral lymph contained 61.7 +/- 8.5% of the administered hGH dose.

    In plain wordsIn sheep, peripheral lymph contained 61.7 +/- 8.5% of the administered hGH dose.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicablePeripheral lymph dose recovery
    Study

    Sheepn: not reported in source

    Lymphatic transport model
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · SubcutaneousAs given in this study (Sheep).

    Source sentences

    Summary
    The fraction of the administered dose collected in peripheral lymph was 61.7 +/- 8.5% (mean +/- SEM), whereas only 8.6 +/- 1.3% was collected in central lymph.
    1 context sentence
    Summary · context
    The animal model utilized a sheep and enabled simultaneous sampling of blood and collection of either peripheral lymph (via the efferent duct of the popliteal lymph node draining the injection site) or central lymph (via the thoracic lymph duct).
  5. 05AnimalAnimal study (in vivo)Pharmacokinetics

    In sheep, central lymph contained 8.6 +/- 1.3% of the administered hGH dose.

    In plain wordsIn sheep, central lymph contained 8.6 +/- 1.3% of the administered hGH dose.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableCentral lymph dose recovery
    Study

    Sheepn: not reported in source

    Lymphatic transport model
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · SubcutaneousAs given in this study (Sheep).

    Source sentences

    Summary
    The fraction of the administered dose collected in peripheral lymph was 61.7 +/- 8.5% (mean +/- SEM), whereas only 8.6 +/- 1.3% was collected in central lymph.
    1 context sentence
    Summary · context
    The animal model utilized a sheep and enabled simultaneous sampling of blood and collection of either peripheral lymph (via the efferent duct of the popliteal lymph node draining the injection site) or central lymph (via the thoracic lymph duct).
  6. 06AnimalAnimal study (in vivo)Pharmacokinetics

    In peripherally cannulated sheep, total hGH recovery was approximately 93% of the dose, indicating minimal injection-site loss.

    In plain wordsIn peripherally cannulated sheep, total hGH recovery was approximately 93% of the dose.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableTotal dose recovery
    Study

    Sheepn: not reported in source

    Lymphatic transport model
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · SubcutaneousAs given in this study (Sheep).

    Source sentences

    Summary
    The total recovery (sum of the systemic availability and the cumulative amount recovered in lymph) of hGH was approximately 93% of the dose in the peripherally-cannulated group indicating that loss at the injection site was minimal.
    1 context sentence
    Summary · context
    The animal model utilized a sheep and enabled simultaneous sampling of blood and collection of either peripheral lymph (via the efferent duct of the popliteal lymph node draining the injection site) or central lymph (via the thoracic lymph duct).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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