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Study · Randomized controlled trial · n = 115 · 2000

10 results

Prospective, randomized, controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing hormone-releasing hormone (LH-RH) antagonist (cetrorelix) or a depot formula of an LH-RH agonist (triptorelin).

Olivennes F, Belaisch-Allart J, Emperaire JC, Dechaud H, Alvarez S, Moreau L, Nicollet B, Zorn JR, Bouchard P, Frydman R

Fertility and sterility1 Feb 2000Cited by 163 (Europe PMC)

PMID10685535 (opens in a new tab)DOI10.1016/s0015-0282(99)00524-5 (opens in a new tab)PepBankPUB-10685535
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In infertile IVF-ET patients, the cetrorelix protocol produced fewer oocytes than the depot triptorelin protocol.

    In plain wordsIn infertile IVF-ET patients, the cetrorelix protocol produced fewer oocytes than the depot triptorelin protocol.

    Peptide
    Cetrorelix
    Outcome
    DecreaseOocytes retrieved
    Study

    n: not reported in source

    Comparator
    Depot triptorelin protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    The patients in the cetrorelix group had a lower number of oocytes and embryos.
    5 context sentences
    Summary · context
    Multicenter randomized, prospective study.
    Summary · context
    Infertile patients undergoing ovarian stimulation for IVF-ET.
    Summary · context
    A single dose of 3 mg of cetrorelix (Cetrotide; ASTA Medica, Frankfurt, Germany) (115 patients) was administered in the late follicular phase.
    Summary · context
    A depot preparation of triptorelin (Decapeptyl; Ipsen-Biotech, Paris, France) was chosen as a control agent (39 patients).
    Summary · context
    Ovarian stimulation was conducted with hMG (Menogon; Ferring, Kiel, Germany).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In infertile IVF-ET patients, the cetrorelix protocol produced fewer embryos than the depot triptorelin protocol.

    In plain wordsIn infertile IVF-ET patients, the cetrorelix protocol produced fewer embryos than the depot triptorelin protocol.

    Peptide
    Cetrorelix
    Outcome
    DecreaseEmbryo number
    Study

    n: not reported in source

    Comparator
    Depot triptorelin protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    The patients in the cetrorelix group had a lower number of oocytes and embryos.
    5 context sentences
    Summary · context
    Multicenter randomized, prospective study.
    Summary · context
    Infertile patients undergoing ovarian stimulation for IVF-ET.
    Summary · context
    A single dose of 3 mg of cetrorelix (Cetrotide; ASTA Medica, Frankfurt, Germany) (115 patients) was administered in the late follicular phase.
    Summary · context
    A depot preparation of triptorelin (Decapeptyl; Ipsen-Biotech, Paris, France) was chosen as a control agent (39 patients).
    Summary · context
    Ovarian stimulation was conducted with hMG (Menogon; Ferring, Kiel, Germany).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In infertile IVF-ET patients, mature oocyte percentages were similar between cetrorelix and depot triptorelin protocols.

    In plain wordsIn infertile IVF-ET patients, mature oocyte percentages were similar between cetrorelix and depot triptorelin protocols.

    Peptide
    Cetrorelix
    Outcome
    Direction not reportedMature oocyte percentage
    Study

    n: not reported in source

    Comparator
    Depot triptorelin protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    The percentage of mature oocytes and fertilization rates were similar in both groups, and the pregnancy rates were not statistically different.
    5 context sentences
    Summary · context
    Multicenter randomized, prospective study.
    Summary · context
    Infertile patients undergoing ovarian stimulation for IVF-ET.
    Summary · context
    A single dose of 3 mg of cetrorelix (Cetrotide; ASTA Medica, Frankfurt, Germany) (115 patients) was administered in the late follicular phase.
    Summary · context
    A depot preparation of triptorelin (Decapeptyl; Ipsen-Biotech, Paris, France) was chosen as a control agent (39 patients).
    Summary · context
    Ovarian stimulation was conducted with hMG (Menogon; Ferring, Kiel, Germany).
  4. 04HumanRandomized controlled trialEfficacy outcome

    In infertile IVF-ET patients, fertilization rates were similar between cetrorelix and depot triptorelin protocols.

    In plain wordsIn infertile IVF-ET patients, fertilization rates were similar between cetrorelix and depot triptorelin protocols.

    Peptide
    Cetrorelix
    Outcome
    Direction not reportedFertilization rate
    Study

    n: not reported in source

    Comparator
    Depot triptorelin protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    The percentage of mature oocytes and fertilization rates were similar in both groups, and the pregnancy rates were not statistically different.
    5 context sentences
    Summary · context
    Multicenter randomized, prospective study.
    Summary · context
    Infertile patients undergoing ovarian stimulation for IVF-ET.
    Summary · context
    A single dose of 3 mg of cetrorelix (Cetrotide; ASTA Medica, Frankfurt, Germany) (115 patients) was administered in the late follicular phase.
    Summary · context
    A depot preparation of triptorelin (Decapeptyl; Ipsen-Biotech, Paris, France) was chosen as a control agent (39 patients).
    Summary · context
    Ovarian stimulation was conducted with hMG (Menogon; Ferring, Kiel, Germany).
  5. 05HumanRandomized controlled trialEfficacy outcome

    In infertile IVF-ET patients, pregnancy rates did not differ statistically between cetrorelix and depot triptorelin protocols.

    In plain wordsIn infertile IVF-ET patients, pregnancy rates did not differ statistically between cetrorelix and depot triptorelin protocols.

    Peptide
    Cetrorelix
    Outcome
    No significant changePregnancy rate
    Study

    n: not reported in source

    Comparator
    Depot triptorelin protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    The percentage of mature oocytes and fertilization rates were similar in both groups, and the pregnancy rates were not statistically different.
    5 context sentences
    Summary · context
    Multicenter randomized, prospective study.
    Summary · context
    Infertile patients undergoing ovarian stimulation for IVF-ET.
    Summary · context
    A single dose of 3 mg of cetrorelix (Cetrotide; ASTA Medica, Frankfurt, Germany) (115 patients) was administered in the late follicular phase.
    Summary · context
    A depot preparation of triptorelin (Decapeptyl; Ipsen-Biotech, Paris, France) was chosen as a control agent (39 patients).
    Summary · context
    Ovarian stimulation was conducted with hMG (Menogon; Ferring, Kiel, Germany).
  6. 06HumanRandomized controlled trialEfficacy outcome

    In infertile IVF-ET patients, stimulation duration was shorter with the cetrorelix protocol than with the depot triptorelin protocol.

    In plain wordsIn infertile IVF-ET patients, stimulation duration was shorter with the cetrorelix protocol than with the depot triptorelin protocol.

    Peptide
    Cetrorelix
    Outcome
    DecreaseStimulation duration
    Study

    n: not reported in source

    Comparator
    Depot triptorelin protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    The length of stimulation, number of hMG ampules administered, and occurrence of the ovarian hyperstimulation syndrome were lower in the cetrorelix group.
    5 context sentences
    Summary · context
    Multicenter randomized, prospective study.
    Summary · context
    Infertile patients undergoing ovarian stimulation for IVF-ET.
    Summary · context
    A single dose of 3 mg of cetrorelix (Cetrotide; ASTA Medica, Frankfurt, Germany) (115 patients) was administered in the late follicular phase.
    Summary · context
    A depot preparation of triptorelin (Decapeptyl; Ipsen-Biotech, Paris, France) was chosen as a control agent (39 patients).
    Summary · context
    Ovarian stimulation was conducted with hMG (Menogon; Ferring, Kiel, Germany).
  7. 07HumanRandomized controlled trialEfficacy outcome

    In infertile IVF-ET patients, the cetrorelix protocol required fewer hMG ampules than the depot triptorelin protocol.

    In plain wordsIn infertile IVF-ET patients, the cetrorelix protocol required fewer hMG ampules than the depot triptorelin protocol.

    Peptide
    Cetrorelix
    Outcome
    DecreasehMG ampules administered
    Study

    n: not reported in source

    Comparator
    Depot triptorelin protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    The length of stimulation, number of hMG ampules administered, and occurrence of the ovarian hyperstimulation syndrome were lower in the cetrorelix group.
    5 context sentences
    Summary · context
    Multicenter randomized, prospective study.
    Summary · context
    Infertile patients undergoing ovarian stimulation for IVF-ET.
    Summary · context
    A single dose of 3 mg of cetrorelix (Cetrotide; ASTA Medica, Frankfurt, Germany) (115 patients) was administered in the late follicular phase.
    Summary · context
    A depot preparation of triptorelin (Decapeptyl; Ipsen-Biotech, Paris, France) was chosen as a control agent (39 patients).
    Summary · context
    Ovarian stimulation was conducted with hMG (Menogon; Ferring, Kiel, Germany).
  8. 08HumanRandomized controlled trialSafety outcome

    In infertile IVF-ET patients, ovarian hyperstimulation syndrome occurred less often with cetrorelix than with the depot triptorelin protocol.

    In plain wordsIn infertile IVF-ET patients, ovarian hyperstimulation syndrome occurred less often with cetrorelix than with the depot triptorelin protocol.

    Peptide
    Cetrorelix
    Outcome
    DecreaseOvarian hyperstimulation syndrome
    Study

    n: not reported in source

    Comparator
    Depot triptorelin protocol
    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    3 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    The length of stimulation, number of hMG ampules administered, and occurrence of the ovarian hyperstimulation syndrome were lower in the cetrorelix group.
    5 context sentences
    Summary · context
    Multicenter randomized, prospective study.
    Summary · context
    Infertile patients undergoing ovarian stimulation for IVF-ET.
    Summary · context
    A single dose of 3 mg of cetrorelix (Cetrotide; ASTA Medica, Frankfurt, Germany) (115 patients) was administered in the late follicular phase.
    Summary · context
    A depot preparation of triptorelin (Decapeptyl; Ipsen-Biotech, Paris, France) was chosen as a control agent (39 patients).
    Summary · context
    Ovarian stimulation was conducted with hMG (Menogon; Ferring, Kiel, Germany).
  9. 09HumanNon-randomized trialEfficacy outcome

    In infertile IVF-ET patients, no LH surge occurred after cetrorelix administration.

    In plain wordsIn infertile IVF-ET patients, no LH surge occurred after cetrorelix administration.

    Peptide
    Cetrorelix
    Outcome
    Not applicablePremature LH surges
    Study

    n = 115

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    No LH surge occurred after cetrorelix administration.
    5 context sentences
    Summary · context
    Multicenter randomized, prospective study.
    Summary · context
    Infertile patients undergoing ovarian stimulation for IVF-ET.
    Summary · context
    A single dose of 3 mg of cetrorelix (Cetrotide; ASTA Medica, Frankfurt, Germany) (115 patients) was administered in the late follicular phase.
    Summary · context
    A depot preparation of triptorelin (Decapeptyl; Ipsen-Biotech, Paris, France) was chosen as a control agent (39 patients).
    Summary · context
    Ovarian stimulation was conducted with hMG (Menogon; Ferring, Kiel, Germany).
  10. 10HumanNon-randomized trialSafety outcome

    In infertile IVF-ET patients, tolerance of cetrorelix was reported as excellent.

    In plain wordsIn infertile IVF-ET patients, tolerance of cetrorelix was reported as excellent.

    Peptide
    Cetrorelix
    Outcome
    Not applicableTolerance
    Study

    n = 115

    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    3 mg · single doseAs given in this study (human).

    Source sentences

    Summary
    Tolerance of cetrorelix was excellent.
    5 context sentences
    Summary · context
    Multicenter randomized, prospective study.
    Summary · context
    Infertile patients undergoing ovarian stimulation for IVF-ET.
    Summary · context
    A single dose of 3 mg of cetrorelix (Cetrotide; ASTA Medica, Frankfurt, Germany) (115 patients) was administered in the late follicular phase.
    Summary · context
    A depot preparation of triptorelin (Decapeptyl; Ipsen-Biotech, Paris, France) was chosen as a control agent (39 patients).
    Summary · context
    Ovarian stimulation was conducted with hMG (Menogon; Ferring, Kiel, Germany).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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