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Study · Not a test of the peptide alone · 2000

9 results

Antimicrobial effects of alpha-MSH peptides.

Cutuli M, Cristiani S, Lipton JM, Catania A

Journal of leukocyte biology1 Feb 2000Cited by 110 (Europe PMC)

PMID10670585 (opens in a new tab)DOI10.1002/jlb.67.2.233 (opens in a new tab)PepBankPUB-10670585
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking KPV.

  1. 01LabNot a test of KPV aloneIn vitro (cells)Activity measurement

    In lab tests, alpha-MSH peptides, including KPV, significantly inhibited S. aureus colony formation.

    In plain wordsIn lab tests, alpha-MSH peptides, including KPV, reduced the growth of Staphylococcus aureus bacteria.

    Peptide
    KPV
    Outcome
    DecreaseS. aureus colony formation
    Study

    Staphylococcus aureusn: not reported in source

    bacterial culture
    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    alpha-MSH peptides significantly inhibited S. aureus colony formation and reversed the enhancing effect of urokinase on colony formation.
    1 context sentence
    Summary · context
    alpha-MSH and and its carboxy-terminal tripeptide (11-13, KPV) were determined to have antimicrobial influences against two major and representative pathogens: Staphylococcus aureus and Candida albicans.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  2. 02LabNot a test of KPV aloneIn vitro (cells)Activity measurement

    In lab tests, alpha-MSH peptides, including KPV, reversed the enhancing effect of urokinase on S. aureus colony formation.

    In plain wordsIn lab tests, alpha-MSH peptides, including KPV, reversed the extra bacterial growth caused by urokinase.

    Peptide
    KPV
    Outcome
    DecreaseReversal of urokinase-enhanced S. aureus colony formation
    Study

    Staphylococcus aureusn: not reported in source

    bacterial culture
    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    alpha-MSH peptides significantly inhibited S. aureus colony formation and reversed the enhancing effect of urokinase on colony formation.
    1 context sentence
    Summary · context
    alpha-MSH and and its carboxy-terminal tripeptide (11-13, KPV) were determined to have antimicrobial influences against two major and representative pathogens: Staphylococcus aureus and Candida albicans.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  3. 03LabNot a test of KPV aloneIn vitro (cells)Activity measurement

    In lab tests, alpha-MSH peptides, including KPV, had antimicrobial effects over a broad range of concentrations, including the physiological picomolar range.

    In plain wordsIn lab tests, alpha-MSH peptides, including KPV, had antimicrobial effects over a broad concentration range, including very low amounts.

    Peptide
    KPV
    Outcome
    Not applicableAntimicrobial effect across concentration range
    Study

    S. aureus and C. albicansn: not reported in source

    microbial culture
    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    Antimicrobial effects occurred over a broad range of concentrations including the physiological (picomolar) range.
    1 context sentence
    Summary · context
    alpha-MSH and and its carboxy-terminal tripeptide (11-13, KPV) were determined to have antimicrobial influences against two major and representative pathogens: Staphylococcus aureus and Candida albicans.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  4. 04LabNot a test of KPV aloneIn vitro (cells)Activity measurement

    In lab tests, small concentrations of alpha-MSH peptides, including KPV, reduced the viability of C. albicans.

    In plain wordsIn lab tests, small amounts of alpha-MSH peptides, including KPV, reduced the survival of Candida albicans yeast.

    Peptide
    KPV
    Outcome
    DecreaseC. albicans viability
    Study

    Candida albicansn: not reported in source

    yeast culture
    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    Small concentrations of alpha-MSH peptides likewise reduced viability and germ tube formation of the yeast C. albicans.
    1 context sentence
    Summary · context
    alpha-MSH and and its carboxy-terminal tripeptide (11-13, KPV) were determined to have antimicrobial influences against two major and representative pathogens: Staphylococcus aureus and Candida albicans.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  5. 05LabNot a test of KPV aloneIn vitro (cells)Activity measurement

    In lab tests, small concentrations of alpha-MSH peptides, including KPV, reduced germ tube formation of C. albicans.

    In plain wordsIn lab tests, small amounts of alpha-MSH peptides, including KPV, reduced germ tube formation in Candida albicans yeast.

    Peptide
    KPV
    Outcome
    DecreaseC. albicans germ tube formation
    Study

    Candida albicansn: not reported in source

    yeast culture
    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    Small concentrations of alpha-MSH peptides likewise reduced viability and germ tube formation of the yeast C. albicans.
    1 context sentence
    Summary · context
    alpha-MSH and and its carboxy-terminal tripeptide (11-13, KPV) were determined to have antimicrobial influences against two major and representative pathogens: Staphylococcus aureus and Candida albicans.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  6. 06LabNot a test of KPV aloneIn vitro (cells)Mechanism

    In yeast, alpha-MSH peptides, including KPV, significantly increased cellular cAMP.

    In plain wordsIn lab tests, alpha-MSH peptides, including KPV, raised cAMP levels in yeast.

    Peptide
    KPV
    Outcome
    IncreaseCellular cAMP in peptide-treated yeast
    Study

    Candida albicansn: not reported in source

    yeast culture
    Outcome group
    Receptor activity and mechanism · Infection

    Source sentences

    Summary
    this messenger was significantly augmented in peptide-treated yeast and the potent adenylyl cyclase inhibitor dideoxyadenosine (ddAdo) partly reversed the killing activity of alpha-MSH peptides.
    1 context sentence
    Summary · context
    alpha-MSH and and its carboxy-terminal tripeptide (11-13, KPV) were determined to have antimicrobial influences against two major and representative pathogens: Staphylococcus aureus and Candida albicans.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  7. 07LabNot a test of KPV aloneIn vitro (cells)Mechanism

    In yeast, the adenylyl cyclase inhibitor ddAdo partly reversed the killing activity of alpha-MSH peptides, including KPV.

    In plain wordsIn lab tests, a cAMP-blocking drug partly undid the yeast-killing effect of alpha-MSH peptides, including KPV.

    Peptide
    KPV
    Outcome
    Not applicableKilling activity after adenylyl cyclase inhibition (ddAdo)
    Study

    Candida albicansn: not reported in source

    yeast culture
    Outcome group
    Receptor activity and mechanism · Infection

    Source sentences

    Summary
    the potent adenylyl cyclase inhibitor dideoxyadenosine (ddAdo) partly reversed the killing activity of alpha-MSH peptides.
    1 context sentence
    Summary · context
    alpha-MSH and and its carboxy-terminal tripeptide (11-13, KPV) were determined to have antimicrobial influences against two major and representative pathogens: Staphylococcus aureus and Candida albicans.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  8. 08LabNot a test of KPV aloneIn vitro (cells)Activity measurement

    In human neutrophil assays, alpha-MSH peptides, including KPV, did not reduce killing of C. albicans but enhanced it.

    In plain wordsIn lab tests, alpha-MSH peptides, including KPV, did not weaken human white cells killing yeast; they increased it.

    Peptide
    KPV
    Outcome
    IncreaseC. albicans killing by human neutrophils
    Study

    humann: not reported in source

    human neutrophils with C. albicans
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    alpha-MSH peptides did not reduce killing but rather enhanced it
    2 context sentences
    Summary · context
    we determined influences of alpha-MSH on C. albicans and S. aureus killing by human neutrophils.
    Summary · context
    alpha-MSH and and its carboxy-terminal tripeptide (11-13, KPV) were determined to have antimicrobial influences against two major and representative pathogens: Staphylococcus aureus and Candida albicans.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  9. 09LabNot a test of KPV aloneIn vitro (cells)Activity measurement

    In human neutrophil assays, alpha-MSH peptides, including KPV, did not reduce killing of S. aureus but enhanced it.

    In plain wordsIn lab tests, alpha-MSH peptides, including KPV, did not weaken human white cells killing bacteria; they increased it.

    Peptide
    KPV
    Outcome
    IncreaseS. aureus killing by human neutrophils
    Study

    humann: not reported in source

    human neutrophils with S. aureus
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    alpha-MSH peptides did not reduce killing but rather enhanced it
    2 context sentences
    Summary · context
    we determined influences of alpha-MSH on C. albicans and S. aureus killing by human neutrophils.
    Summary · context
    alpha-MSH and and its carboxy-terminal tripeptide (11-13, KPV) were determined to have antimicrobial influences against two major and representative pathogens: Staphylococcus aureus and Candida albicans.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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