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Study · Animal study (in vivo) · mouse · 2000

2 results

Functional interplay between gelatinases and hyperalgesia in endotoxin-induced localized inflammatory pain.

Talhouk RS, Hajjar L, Abou-Gergi R, Simaa'n CJ, Mouneimne G, Saade' NE, Safieh-Garabedian B

Pain1 Feb 2000Cited by 15 (Europe PMC)

PMID10666546 (opens in a new tab)DOI10.1016/s0304-3959(99)00238-9 (opens in a new tab)PepBankPUB-10666546
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, thymulin reversed endotoxin-induced hyperalgesia.

    In plain wordsIn mice, thymulin reversed pain sensitivity caused by endotoxin.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseEndotoxin-induced hyperalgesia
    Study

    mousen: not reported in source

    Balb/c mice with endotoxin-induced localized inflammation
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    5 microg/100 microl · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Intraperitoneal injection of either ZnCl(2) (100 microM), thymulin (5 microg/100 microl), or morphine (2 mg/kg/100 microl) reversed the ET-induced hyperalgesia and suppressed gelatinase activity.
    1 context sentence
    Summary · context
    The goal of this study is to describe the regulation of gelatinases during endotoxin mediated local inflammation, induced by intra plantar endotoxin (ET; 1.25 microg/50 microl) injection in Balb/c mice, and to correlate that with hyperalgesia.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, thymulin suppressed gelatinase activity during endotoxin-induced inflammation.

    In plain wordsIn mice, thymulin reduced gelatinase activity during endotoxin-induced inflammation.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseGelatinase activity
    Study

    mousen: not reported in source

    Balb/c mice with endotoxin-induced localized inflammation
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 microg/100 microl · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Intraperitoneal injection of either ZnCl(2) (100 microM), thymulin (5 microg/100 microl), or morphine (2 mg/kg/100 microl) reversed the ET-induced hyperalgesia and suppressed gelatinase activity.
    1 context sentence
    Summary · context
    The goal of this study is to describe the regulation of gelatinases during endotoxin mediated local inflammation, induced by intra plantar endotoxin (ET; 1.25 microg/50 microl) injection in Balb/c mice, and to correlate that with hyperalgesia.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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