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Study · Animal study (in vivo) · 2000

3 results

Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction.

Hohmann JG, Teal TH, Clifton DK, Davis J, Hruby VJ, Han G, Steiner RA

American journal of physiology. Regulatory, integrative and comparative physiology1 Jan 2000Cited by 63 (Europe PMC)

PMID10644621 (opens in a new tab)DOI10.1152/ajpregu.2000.278.1.r50 (opens in a new tab)PepBankPUB-10644621
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals, MTII decreased food intake compared with controls.

    In plain wordsIn animals, melanotan II reduced food intake compared with controls.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake
    Study

    n: not reported in source

    Comparator
    Controls
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular and intraperitonealAs given in this study.

    Source sentences

    Summary
    MTII (intracerebroventricularly and intraperitoneally) decreased food intake and increased body temperature compared with controls but had no effect on the reproductive-endocrine axis.
    1 context sentence
    Summary · context
    We tested this hypothesis first by determining whether the effects of leptin on feeding behavior and reproduction in the ob/ob mouse could be blocked by the melanocortin receptor (MC-R) antagonist SHU9119 and second, by examining the effects of the MC-R agonist MTII on feeding and the endocrine-reproductive system.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In animals, MTII increased body temperature compared with controls.

    In plain wordsIn animals, melanotan II raised body temperature compared with controls.

    Peptide
    Melanotan II
    Outcome
    IncreaseBody temperature
    Study

    n: not reported in source

    Comparator
    Controls
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular and intraperitonealAs given in this study.

    Source sentences

    Summary
    MTII (intracerebroventricularly and intraperitoneally) decreased food intake and increased body temperature compared with controls but had no effect on the reproductive-endocrine axis.
    1 context sentence
    Summary · context
    We tested this hypothesis first by determining whether the effects of leptin on feeding behavior and reproduction in the ob/ob mouse could be blocked by the melanocortin receptor (MC-R) antagonist SHU9119 and second, by examining the effects of the MC-R agonist MTII on feeding and the endocrine-reproductive system.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In animals, MTII had no effect on the reproductive-endocrine axis.

    In plain wordsIn animals, melanotan II had no effect on the reproductive hormone system.

    Peptide
    Melanotan II
    Outcome
    No significant changeReproductive-endocrine axis
    Study

    n: not reported in source

    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intracerebroventricular and intraperitonealAs given in this study.

    Source sentences

    Summary
    MTII (intracerebroventricularly and intraperitoneally) decreased food intake and increased body temperature compared with controls but had no effect on the reproductive-endocrine axis.
    1 context sentence
    Summary · context
    We tested this hypothesis first by determining whether the effects of leptin on feeding behavior and reproduction in the ob/ob mouse could be blocked by the melanocortin receptor (MC-R) antagonist SHU9119 and second, by examining the effects of the MC-R agonist MTII on feeding and the endocrine-reproductive system.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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