Sustained release of human growth hormone from PLGA solution depots.

Brodbeck KJ, Pushpala S, McHugh AJ

Pharmaceutical research1 Dec 1999Cited by 60 (Europe PMC)

PMID10644069DOI10.1023/a:1018943107688PepBankPUB-10644069

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Pharmacokinetics
In normal rats, hGH-loaded PLGA depots with low aqueous-affinity solvent and densified particles sustained serum hGH at 10 to 200 ng/ml for 28 days.
In plain wordsIn rats, hGH-loaded PLGA depots sustained serum hGH at 10 to 200 ng/ml for 28 days.
Peptide
HGH (somatotropin)
Outcome
Not applicableSustained serum hGH
Study
ratn: not reported in source
Normal rats receiving subcutaneous PLGA hGH depots
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
By taking advantage of the effects of low aqueous affinity and protein particle densification, a PLGA solution depot was produced with the capability of sustaining hGH levels in normal rats at a serum level of 10 to 200 ng/ml for 28 days.
2 context sentences(design, population, supporting numbers)
Summary · context
An extended-release profile and significantly reduced burst effect resulted when the aqueous affinity of the depot solvent was reduced.
Summary · context
Protein release profiles of depots prepared from four model solvents were generated by injecting formulations into the subcutaneous space of normal rats and monitoring hGH serum levels over the course of 1 month.
Report a problemFND-1064406904

Studies that did not test the peptide alone3

In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking HGH (somatotropin).

02AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Pharmacokinetics
In rats, lower aqueous-affinity depot solvent extended hGH release.
In plain wordsIn rats, lower aqueous-affinity depot solvent extended hGH release compared with higher aqueous-affinity solvent.
Peptide
HGH (somatotropin)
Outcome
IncreaseExtended release profile
Study
ratn: not reported in source
Normal rats receiving subcutaneous PLGA hGH depots
Comparator
Higher aqueous-affinity depot solvent
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
An extended-release profile and significantly reduced burst effect resulted when the aqueous affinity of the depot solvent was reduced.
1 context sentence(design, population, supporting numbers)
Summary · context
Protein release profiles of depots prepared from four model solvents were generated by injecting formulations into the subcutaneous space of normal rats and monitoring hGH serum levels over the course of 1 month.
In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).
Report a problemFND-1064406901
03AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Pharmacokinetics
In rats, lower aqueous-affinity depot solvent significantly reduced the hGH burst effect.
In plain wordsIn rats, lower aqueous-affinity depot solvent reduced the hGH burst effect compared with higher aqueous-affinity solvent.
Peptide
HGH (somatotropin)
Outcome
DecreaseInjection burst effect
Study
ratn: not reported in source
Normal rats receiving subcutaneous PLGA hGH depots
Comparator
Higher aqueous-affinity depot solvent
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
An extended-release profile and significantly reduced burst effect resulted when the aqueous affinity of the depot solvent was reduced.
1 context sentence(design, population, supporting numbers)
Summary · context
Protein release profiles of depots prepared from four model solvents were generated by injecting formulations into the subcutaneous space of normal rats and monitoring hGH serum levels over the course of 1 month.
In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).
Report a problemFND-1064406902
04AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Pharmacokinetics
In rats, densifying lyophilized hGH particles eliminated injection burst in a slow phase-inverting depot formulation.
In plain wordsIn rats, densified hGH particles eliminated injection burst compared with undensified particles in a slow phase-inverting formulation.
Peptide
HGH (somatotropin)
Outcome
DecreaseBurst elimination by particle densification
Study
ratn: not reported in source
Normal rats receiving subcutaneous PLGA hGH depots
Comparator
Undensified protein particles
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
Protein burst on injection was entirely eliminated in a slow phase-inverting formulation by densifying the lyophilized protein particles.
1 context sentence(design, population, supporting numbers)
Summary · context
Protein release profiles of depots prepared from four model solvents were generated by injecting formulations into the subcutaneous space of normal rats and monitoring hGH serum levels over the course of 1 month.
In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).
Report a problemFND-1064406903

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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