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Study · Not a test of the peptide alone · 2000

2 results

Leptin increases in vivo GH responses to GHRH and GH-releasing peptide-6 in food-deprived rats.

Carro E, Seoane LM, Señaris R, Casanueva FF, Dieguez C

European journal of endocrinology1 Jan 2000Cited by 15 (Europe PMC)

PMID10633224 (opens in a new tab)DOI10.1530/eje.0.1420066 (opens in a new tab)PepBankPUB-10633224
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In rats, food deprivation reduced GH responses to GHRP‑6 compared with feeding.

    In plain wordsIn rats, GHRP‑6 produced less growth hormone during food deprivation than during feeding.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH response during food deprivation
    Study

    ratn: not reported in source

    freely moving rats
    Comparator
    fed rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    In comparison with fed rats, food-deprived rats showed a marked decrease in GH responses
    2 context sentences
    Summary · context
    and GHRP-6 (3695+/-450 in fed rats and 1432+/-229 in fasted rats; P<0.05).
    Summary · context
    Leptin (10microg i.c.v.) or vehicle was administered at random before GHRH (10microg/kg i,v.) or GHRP-6 (50microg/kg i.v.), to freely-moving rats with food available ad libitum and to (48h) food-deprived rats.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In food-deprived rats, leptin increased GH responses to GHRP‑6 compared with vehicle.

    In plain wordsIn food-deprived rats, leptin increased the growth hormone response to GHRP‑6 compared with vehicle.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response after leptin in food-deprived rats
    Study

    ratn: not reported in source

    freely moving rats
    Comparator
    vehicle-treated food-deprived rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    In comparison with its effects in vehicle-treated rats, leptin administered to food-deprived rats markedly increased GH responses to both GHRH (6625+/-613ng/ml; P<0.05) and GHRP-6 (5862+/-441ng/ml; P<0.05).
    1 context sentence
    Summary · context
    Leptin (10microg i.c.v.) or vehicle was administered at random before GHRH (10microg/kg i,v.) or GHRP-6 (50microg/kg i.v.), to freely-moving rats with food available ad libitum and to (48h) food-deprived rats.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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