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Study · In vitro (cells) · rat · 1999

2 results

Characterization of the IGF axis in a rat liver-derived epithelial cell line.

Bramani S, Allan GJ, Beattie J

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society1 Dec 1999Cited by 2 (Europe PMC)

PMID10629162 (opens in a new tab)DOI10.1054/ghir.1999.0120 (opens in a new tab)PepBankPUB-10629162
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In rat liver-derived epithelial cells, des IGF-I had greater acute signalling activity than wild-type IGF-I.

    In plain wordsIn cells derived from rat liver, des IGF-I had greater acute signalling activity than wild-type IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseAcute signalling activity
    Study

    ratn: not reported in source

    Rat liver-derived epithelial cell line
    Comparator
    Wild-type IGF-I
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Dose-response experiments indicate an enhanced biological activity of the IGF-I analogue des (1-3) IGF-I compared to wild-type IGF-I in both acute signalling experiments and longer-term (24 h) mitogenic assays.
  2. 02LabIn vitro (cells)Activity measurement

    In rat liver-derived epithelial cells, des IGF-I had greater mitogenic activity than wild-type IGF-I.

    In plain wordsIn cells derived from rat liver, des IGF-I stimulated cell growth more than wild-type IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseMitogenic activity
    Study

    ratn: not reported in source

    Rat liver-derived epithelial cell line
    Comparator
    Wild-type IGF-I
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated · 24 hAs given in this study (rat).

    Source sentences

    Summary
    Dose-response experiments indicate an enhanced biological activity of the IGF-I analogue des (1-3) IGF-I compared to wild-type IGF-I in both acute signalling experiments and longer-term (24 h) mitogenic assays.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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