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Study · Measured the body's own peptide · 1999

5 results

Inhibitory effect of natural and environmental estrogens on thymic hormone production in thymus epithelial cell culture.

Sakabe K, Okuma M, Karaki S, Matsuura S, Yoshida T, Aikawa H, Izumi S, Kayama F

International journal of immunopharmacology1 Dec 1999Cited by 12 (Europe PMC)

PMID10606005 (opens in a new tab)DOI10.1016/s0192-0561(99)00054-5 (opens in a new tab)PepBankPUB-10606005
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In cultured murine thymus epithelial cells, 17beta-estradiol above 3 x 10(-11) M significantly inhibited production of the cells' own thymosin alpha‑1.

    In plain wordsIn mouse thymus cells in the lab, estradiol lowered the cells' own production of thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseThymosin-alpha 1 production with 17beta-estradiol
    Study

    mousen: not reported in source

    murine thymus epithelial cell culture
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The production of thymosin-alpha 1 by TECs was significantly inhibited by increasing concentrations of 17beta-estradiol (natural estrogen) over 3 x 10(-11) M, genistein (phytoestrogen) over 3 x 10(-9) M, coumestrol (phytoestrogen) over 3 x 10(-9) M, alpha-zearalanol (livestock anabolic) over 3 x 10(…
    1 context sentence
    Summary · context
    Murine TECs were cultured in the experimental DMEM medium containing various concentrations of natural or environmental estrogens, which was followed by determining the production of thymosin-alpha 1.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In cultured murine thymus epithelial cells, genistein above 3 x 10(-9) M significantly inhibited production of the cells' own thymosin alpha‑1.

    In plain wordsIn mouse thymus cells in the lab, genistein lowered the cells' own production of thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseThymosin-alpha 1 production with genistein
    Study

    mousen: not reported in source

    murine thymus epithelial cell culture
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The production of thymosin-alpha 1 by TECs was significantly inhibited by increasing concentrations of 17beta-estradiol (natural estrogen) over 3 x 10(-11) M, genistein (phytoestrogen) over 3 x 10(-9) M, coumestrol (phytoestrogen) over 3 x 10(-9) M, alpha-zearalanol (livestock anabolic) over 3 x 10(…
    1 context sentence
    Summary · context
    Murine TECs were cultured in the experimental DMEM medium containing various concentrations of natural or environmental estrogens, which was followed by determining the production of thymosin-alpha 1.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In cultured murine thymus epithelial cells, coumestrol above 3 x 10(-9) M significantly inhibited production of the cells' own thymosin alpha‑1.

    In plain wordsIn mouse thymus cells in the lab, coumestrol lowered the cells' own production of thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseThymosin-alpha 1 production with coumestrol
    Study

    mousen: not reported in source

    murine thymus epithelial cell culture
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The production of thymosin-alpha 1 by TECs was significantly inhibited by increasing concentrations of 17beta-estradiol (natural estrogen) over 3 x 10(-11) M, genistein (phytoestrogen) over 3 x 10(-9) M, coumestrol (phytoestrogen) over 3 x 10(-9) M, alpha-zearalanol (livestock anabolic) over 3 x 10(…
    1 context sentence
    Summary · context
    Murine TECs were cultured in the experimental DMEM medium containing various concentrations of natural or environmental estrogens, which was followed by determining the production of thymosin-alpha 1.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Mechanism

    In cultured murine thymus epithelial cells, alpha-zearalanol above 3 x 10(-7) M significantly inhibited production of the cells' own thymosin alpha‑1.

    In plain wordsIn mouse thymus cells in the lab, alpha-zearalanol lowered the cells' own production of thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseThymosin-alpha 1 production with alpha-zearalanol
    Study

    mousen: not reported in source

    murine thymus epithelial cell culture
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The production of thymosin-alpha 1 by TECs was significantly inhibited by increasing concentrations of 17beta-estradiol (natural estrogen) over 3 x 10(-11) M, genistein (phytoestrogen) over 3 x 10(-9) M, coumestrol (phytoestrogen) over 3 x 10(-9) M, alpha-zearalanol (livestock anabolic) over 3 x 10(…
    1 context sentence
    Summary · context
    Murine TECs were cultured in the experimental DMEM medium containing various concentrations of natural or environmental estrogens, which was followed by determining the production of thymosin-alpha 1.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  5. 05LabEndogenous levelIn vitro (cells)Mechanism

    In cultured murine thymus epithelial cells, bisphenol-A above 3 x 10(-6) M significantly inhibited production of the cells' own thymosin alpha‑1.

    In plain wordsIn mouse thymus cells in the lab, bisphenol-A lowered the cells' own production of thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseThymosin-alpha 1 production with bisphenol-A
    Study

    mousen: not reported in source

    murine thymus epithelial cell culture
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The production of thymosin-alpha 1 by TECs was significantly inhibited by increasing concentrations of 17beta-estradiol (natural estrogen) over 3 x 10(-11) M, genistein (phytoestrogen) over 3 x 10(-9) M, coumestrol (phytoestrogen) over 3 x 10(-9) M, alpha-zearalanol (livestock anabolic) over 3 x 10(…
    1 context sentence
    Summary · context
    Murine TECs were cultured in the experimental DMEM medium containing various concentrations of natural or environmental estrogens, which was followed by determining the production of thymosin-alpha 1.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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