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Study · Randomized controlled trial · n = 28 · 1999

10 results

Measures of submaximal aerobic performance evaluate and predict functional response to growth hormone (GH) treatment in GH-deficient adults.

Woodhouse LJ, Asa SL, Thomas SG, Ezzat S

The Journal of clinical endocrinology and metabolism1 Dec 1999Cited by 59 (Europe PMC)

PMID10599721 (opens in a new tab)DOI10.1210/jcem.84.12.6196 (opens in a new tab)PepBankPUB-10599721
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In GH-deficient adults, GH decreased body fat.

    In plain wordsIn GH-deficient adults, GH decreased body fat.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseBody fat
    Study

    n = 28

    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    6.25 microg/kg lean body mass for 1 month, then 12.5 microg/kg lean body mass · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    As expected, GH treatment decreased body fat, increased LBM, increased muscle fiber size, and increased muscle insulin-like growth factor-I messenger RNA 5-fold; however, muscle strength remained unchanged.
    1 context sentence
    Summary · context
    To investigate the effects of GH on skeletal muscle, physical, and functional capacity, we randomized 28 GH-deficient adults to receive 3 months of recombinant human GH [rhGH: somatotropin, 6.25 microg/kg lean body mass (LBM) for 1 month, 12.5 microg/kg LBM thereafter] in a double-blind placebo-cont…
  2. 02HumanRandomized controlled trialEfficacy outcome

    In GH-deficient adults, GH increased lean body mass.

    In plain wordsIn GH-deficient adults, GH increased lean body mass.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseLean body mass
    Study

    n = 28

    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    6.25 microg/kg lean body mass for 1 month, then 12.5 microg/kg lean body mass · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    As expected, GH treatment decreased body fat, increased LBM, increased muscle fiber size, and increased muscle insulin-like growth factor-I messenger RNA 5-fold; however, muscle strength remained unchanged.
    1 context sentence
    Summary · context
    To investigate the effects of GH on skeletal muscle, physical, and functional capacity, we randomized 28 GH-deficient adults to receive 3 months of recombinant human GH [rhGH: somatotropin, 6.25 microg/kg lean body mass (LBM) for 1 month, 12.5 microg/kg LBM thereafter] in a double-blind placebo-cont…
  3. 03HumanRandomized controlled trialEfficacy outcome

    In GH-deficient adults, GH increased muscle fiber size.

    In plain wordsIn GH-deficient adults, GH increased muscle fiber size.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseMuscle fiber size
    Study

    n = 28

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    6.25 microg/kg lean body mass for 1 month, then 12.5 microg/kg lean body mass · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    As expected, GH treatment decreased body fat, increased LBM, increased muscle fiber size, and increased muscle insulin-like growth factor-I messenger RNA 5-fold; however, muscle strength remained unchanged.
    1 context sentence
    Summary · context
    To investigate the effects of GH on skeletal muscle, physical, and functional capacity, we randomized 28 GH-deficient adults to receive 3 months of recombinant human GH [rhGH: somatotropin, 6.25 microg/kg lean body mass (LBM) for 1 month, 12.5 microg/kg LBM thereafter] in a double-blind placebo-cont…
  4. 04HumanRandomized controlled trialMechanism

    In GH-deficient adults, GH increased muscle IGF-I messenger RNA 5-fold.

    In plain wordsIn GH-deficient adults, GH increased muscle IGF-I messenger RNA fivefold.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseMuscle IGF-I messenger RNA
    Study

    n = 28

    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal
    Studied dose
    6.25 microg/kg lean body mass for 1 month, then 12.5 microg/kg lean body mass · 3 monthsAs given in this study (human).

    Measurements

    Muscle IGF-I messenger RNA increase
    5-fold
    GH-deficient adults after rhGH

    Source sentences

    Summary
    As expected, GH treatment decreased body fat, increased LBM, increased muscle fiber size, and increased muscle insulin-like growth factor-I messenger RNA 5-fold; however, muscle strength remained unchanged.
    1 context sentence
    Summary · context
    To investigate the effects of GH on skeletal muscle, physical, and functional capacity, we randomized 28 GH-deficient adults to receive 3 months of recombinant human GH [rhGH: somatotropin, 6.25 microg/kg lean body mass (LBM) for 1 month, 12.5 microg/kg LBM thereafter] in a double-blind placebo-cont…
  5. 05HumanRandomized controlled trialEfficacy outcome

    In GH-deficient adults, muscle strength remained unchanged after GH treatment.

    In plain wordsIn GH-deficient adults, muscle strength remained unchanged after GH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeMuscle strength
    Study

    n = 28

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    6.25 microg/kg lean body mass for 1 month, then 12.5 microg/kg lean body mass · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    As expected, GH treatment decreased body fat, increased LBM, increased muscle fiber size, and increased muscle insulin-like growth factor-I messenger RNA 5-fold; however, muscle strength remained unchanged.
    1 context sentence
    Summary · context
    To investigate the effects of GH on skeletal muscle, physical, and functional capacity, we randomized 28 GH-deficient adults to receive 3 months of recombinant human GH [rhGH: somatotropin, 6.25 microg/kg lean body mass (LBM) for 1 month, 12.5 microg/kg LBM thereafter] in a double-blind placebo-cont…
  6. 06HumanRandomized controlled trialEfficacy outcome

    In GH-deficient adults, GH increased ventilation threshold by 18% compared with placebo (P = 0.03).

    In plain wordsIn GH-deficient adults, GH increased ventilation threshold compared with placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseVentilation threshold
    Study

    n = 28

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    6.25 microg/kg lean body mass for 1 month, then 12.5 microg/kg lean body mass · 3 monthsAs given in this study (human).

    Measurements

    Ventilation threshold (VeT) increase
    18%
    after rhGH vs placebo

    Source sentences

    Summary
    After rhGH, there was a significant (P = 0.03) increase in VeT (18%), compared with placebo.
    1 context sentence
    Summary · context
    To investigate the effects of GH on skeletal muscle, physical, and functional capacity, we randomized 28 GH-deficient adults to receive 3 months of recombinant human GH [rhGH: somatotropin, 6.25 microg/kg lean body mass (LBM) for 1 month, 12.5 microg/kg LBM thereafter] in a double-blind placebo-cont…
  7. 07HumanRandomized controlled trialEfficacy outcome

    In GH-deficient adults, GH produced a nonsignificant rise in maximal oxygen uptake compared with placebo.

    In plain wordsIn GH-deficient adults, maximal oxygen uptake did not increase significantly with GH compared with placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeMaximal oxygen uptake
    Study

    n = 28

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    6.25 microg/kg lean body mass for 1 month, then 12.5 microg/kg lean body mass · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    This was paralleled by a nonsignificant rise in VO2max.
    2 context sentences
    Summary · context
    After rhGH, there was a significant (P = 0.03) increase in VeT (18%), compared with placebo.
    Summary · context
    To investigate the effects of GH on skeletal muscle, physical, and functional capacity, we randomized 28 GH-deficient adults to receive 3 months of recombinant human GH [rhGH: somatotropin, 6.25 microg/kg lean body mass (LBM) for 1 month, 12.5 microg/kg LBM thereafter] in a double-blind placebo-cont…
  8. 08HumanRandomized controlled trialEfficacy outcome

    In GH-deficient adults, GH decreased walking oxygen cost relative to ventilation threshold by 14% at normal speed (P = 0.019).

    In plain wordsIn GH-deficient adults, GH decreased walking oxygen cost relative to ventilation threshold at normal speed.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseOxygen cost of walking at normal speed
    Study

    n = 28

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    6.25 microg/kg lean body mass for 1 month, then 12.5 microg/kg lean body mass · 3 monthsAs given in this study (human).

    Measurements

    Decrease in oxygen cost of walking relative to VeT
    14%
    normal walking speed after rhGH

    Source sentences

    Summary
    Functionally, rhGH treatment decreased the oxygen cost of walking, relative to VeT, at normal (14% decrease, P = 0.019) and fast (21% decrease, P = 0.004) SPW speeds.
    1 context sentence
    Summary · context
    To investigate the effects of GH on skeletal muscle, physical, and functional capacity, we randomized 28 GH-deficient adults to receive 3 months of recombinant human GH [rhGH: somatotropin, 6.25 microg/kg lean body mass (LBM) for 1 month, 12.5 microg/kg LBM thereafter] in a double-blind placebo-cont…
  9. 09HumanRandomized controlled trialEfficacy outcome

    In GH-deficient adults, GH decreased walking oxygen cost relative to ventilation threshold by 21% at fast speed (P = 0.004).

    In plain wordsIn GH-deficient adults, GH decreased walking oxygen cost relative to ventilation threshold at fast speed.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseOxygen cost of walking at fast speed
    Study

    n = 28

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    6.25 microg/kg lean body mass for 1 month, then 12.5 microg/kg lean body mass · 3 monthsAs given in this study (human).

    Measurements

    Decrease in oxygen cost of walking relative to VeT
    21%
    fast walking speed after rhGH

    Source sentences

    Summary
    Functionally, rhGH treatment decreased the oxygen cost of walking, relative to VeT, at normal (14% decrease, P = 0.019) and fast (21% decrease, P = 0.004) SPW speeds.
    1 context sentence
    Summary · context
    To investigate the effects of GH on skeletal muscle, physical, and functional capacity, we randomized 28 GH-deficient adults to receive 3 months of recombinant human GH [rhGH: somatotropin, 6.25 microg/kg lean body mass (LBM) for 1 month, 12.5 microg/kg LBM thereafter] in a double-blind placebo-cont…
  10. 10HumanObservational studyOther

    In the GH trial in GH-deficient adults, a 3-variable model of baseline fast walking speed, VeT/VO2max and VeT accounted for 39% of the variance of change in self-reported fatigue.

    In plain wordsIn GH-deficient adults, a model using walking speed and ventilation threshold measures accounted for 39% of the variance in fatigue change.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicablePrediction of fatigue response
    Study

    n = 28

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    6.25 microg/kg lean body mass for 1 month, then 12.5 microg/kg lean body mass · 3 monthsAs given in this study (human).

    Measurements

    Variance of change in self-reported fatigue accounted for by 3-variable model
    39%
    GH-deficient adults

    Source sentences

    Summary
    A 3-variable model (baseline fast SPW speed, VeT/VO2max, and VeT) accounted for 39% of the variance of change in self-reported fatigue.
    1 context sentence
    Summary · context
    To investigate the effects of GH on skeletal muscle, physical, and functional capacity, we randomized 28 GH-deficient adults to receive 3 months of recombinant human GH [rhGH: somatotropin, 6.25 microg/kg lean body mass (LBM) for 1 month, 12.5 microg/kg LBM thereafter] in a double-blind placebo-cont…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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