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Study · Measured the body's own peptide · 1999

2 results

The effect of melatonin administration on pituitary hormone secretion in man.

Forsling ML, Wheeler MJ, Williams AJ

Clinical endocrinology1 Nov 1999Cited by 41 (Europe PMC)

PMID10594526 (opens in a new tab)DOI10.1046/j.1365-2265.1999.00820.x (opens in a new tab)PepBankPUB-10594526
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    In healthy young men, melatonin 0.5 mg increased circulating oxytocin concentrations.

    In plain wordsIn healthy young men, a 0.5 mg melatonin dose raised the body's own oxytocin levels.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after melatonin 0.5 mg
    Study

    n = 8

    Comparator
    Placebo
    Outcome group
    Pituitary hormones · Endocrine and hormones

    Source sentences

    Summary
    Melatonin produced dose-dependent changes in circulating concentrations of oxytocin and vasopressin, the 0.5 mg dose being stimulatory, while 5.0 mg was inhibitory.
    1 context sentence
    Summary · context
    A double blind, randomized, crossover study.SubjectsEight healthy male volunteers with a mean age of 21 +/- 0.5 years were studied on four occasions, observations being made after the adminstration of melatonin in doses of 0.05, 0.5 or 5.0 mg or placebo.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialOther

    In healthy young men, melatonin 5.0 mg decreased circulating oxytocin concentrations.

    In plain wordsIn healthy young men, a 5.0 mg melatonin dose lowered the body's own oxytocin levels.

    Peptide
    Oxytocin
    Outcome
    DecreasePlasma oxytocin after melatonin 5.0 mg
    Study

    n = 8

    Comparator
    Placebo
    Outcome group
    Pituitary hormones · Endocrine and hormones

    Source sentences

    Summary
    Melatonin produced dose-dependent changes in circulating concentrations of oxytocin and vasopressin, the 0.5 mg dose being stimulatory, while 5.0 mg was inhibitory.
    1 context sentence
    Summary · context
    A double blind, randomized, crossover study.SubjectsEight healthy male volunteers with a mean age of 21 +/- 0.5 years were studied on four occasions, observations being made after the adminstration of melatonin in doses of 0.05, 0.5 or 5.0 mg or placebo.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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