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Study · Animal study (in vivo) · rat · 1999

11 results

Advantages of concurrent use of anabolic and antiresorptive agents over single use of these agents in increasing trabecular bone volume, connectivity, and biomechanical competence of rat vertebrae.

Kobayashi S, Shimizu T, Mehdi R, Nawata M, Kojima S, Tsutsumimoto T, Iorio R, Takaoka K

Bone1 Dec 1999Cited by 8 (Europe PMC)

PMID10593416 (opens in a new tab)DOI10.1016/s8756-3282(99)00219-7 (opens in a new tab)PepBankPUB-10593416
Publisher pagePubMedAsk about this study
Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PTH monotherapy increased proximal tibial trabecular bone volume versus untreated rats.

    In plain wordsIn rats, PTH alone increased bone volume near the shin bone end compared with untreated rats.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseProximal tibial trabecular bone volume
    Study

    ratn: not reported in source

    male Wistar rats
    Comparator
    untreated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microg/kg daily · injection · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    After 1 month of treatment, the three groups in which PTH was administered (PTH, PTH + E2, and PTH + YM175) had significantly higher trabecular bone volume and connectivity in the proximal tibial metaphyses (PTMs) compared with the untreated and vehicle-treated groups, whereas only combination group…
    1 context sentence
    Summary · context
    The animals were untreated or injected with vehicle, recombinant human PTH(1-84) (PTH; 100 microg/kg daily), 17beta-estradiol (E2, 500 microg/kg every other day), incadronate disodium (YM175, 80 microg/kg every other day), combined PTH and E2 (PTH + E2), or a combination of PTH and YM175 (PTH + YM175).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PTH monotherapy increased proximal tibial trabecular bone volume versus vehicle-treated rats.

    In plain wordsIn rats, PTH alone increased bone volume near the shin bone end compared with vehicle.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseProximal tibial trabecular bone volume
    Study

    ratn: not reported in source

    male Wistar rats
    Comparator
    vehicle-treated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microg/kg daily · injection · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    After 1 month of treatment, the three groups in which PTH was administered (PTH, PTH + E2, and PTH + YM175) had significantly higher trabecular bone volume and connectivity in the proximal tibial metaphyses (PTMs) compared with the untreated and vehicle-treated groups, whereas only combination group…
    1 context sentence
    Summary · context
    The animals were untreated or injected with vehicle, recombinant human PTH(1-84) (PTH; 100 microg/kg daily), 17beta-estradiol (E2, 500 microg/kg every other day), incadronate disodium (YM175, 80 microg/kg every other day), combined PTH and E2 (PTH + E2), or a combination of PTH and YM175 (PTH + YM175).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PTH monotherapy increased proximal tibial trabecular connectivity versus untreated rats.

    In plain wordsIn rats, PTH alone increased bone connections near the shin bone end compared with untreated rats.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseProximal tibial trabecular connectivity
    Study

    ratn: not reported in source

    male Wistar rats
    Comparator
    untreated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microg/kg daily · injection · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    After 1 month of treatment, the three groups in which PTH was administered (PTH, PTH + E2, and PTH + YM175) had significantly higher trabecular bone volume and connectivity in the proximal tibial metaphyses (PTMs) compared with the untreated and vehicle-treated groups, whereas only combination group…
    1 context sentence
    Summary · context
    The animals were untreated or injected with vehicle, recombinant human PTH(1-84) (PTH; 100 microg/kg daily), 17beta-estradiol (E2, 500 microg/kg every other day), incadronate disodium (YM175, 80 microg/kg every other day), combined PTH and E2 (PTH + E2), or a combination of PTH and YM175 (PTH + YM175).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PTH monotherapy increased proximal tibial trabecular connectivity versus vehicle-treated rats.

    In plain wordsIn rats, PTH alone increased bone connections near the shin bone end compared with vehicle.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseProximal tibial trabecular connectivity
    Study

    ratn: not reported in source

    male Wistar rats
    Comparator
    vehicle-treated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microg/kg daily · injection · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    After 1 month of treatment, the three groups in which PTH was administered (PTH, PTH + E2, and PTH + YM175) had significantly higher trabecular bone volume and connectivity in the proximal tibial metaphyses (PTMs) compared with the untreated and vehicle-treated groups, whereas only combination group…
    1 context sentence
    Summary · context
    The animals were untreated or injected with vehicle, recombinant human PTH(1-84) (PTH; 100 microg/kg daily), 17beta-estradiol (E2, 500 microg/kg every other day), incadronate disodium (YM175, 80 microg/kg every other day), combined PTH and E2 (PTH + E2), or a combination of PTH and YM175 (PTH + YM175).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PTH monotherapy did not significantly increase vertebral trabecular bone volume versus untreated rats.

    In plain wordsIn rats, PTH alone did not significantly increase spine bone volume compared with untreated rats.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeVertebral trabecular bone volume
    Study

    ratn: not reported in source

    male Wistar rats
    Comparator
    untreated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microg/kg daily · injection · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    After 1 month of treatment, the three groups in which PTH was administered (PTH, PTH + E2, and PTH + YM175) had significantly higher trabecular bone volume and connectivity in the proximal tibial metaphyses (PTMs) compared with the untreated and vehicle-treated groups, whereas only combination group…
    1 context sentence
    Summary · context
    The animals were untreated or injected with vehicle, recombinant human PTH(1-84) (PTH; 100 microg/kg daily), 17beta-estradiol (E2, 500 microg/kg every other day), incadronate disodium (YM175, 80 microg/kg every other day), combined PTH and E2 (PTH + E2), or a combination of PTH and YM175 (PTH + YM175).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PTH monotherapy did not significantly increase vertebral trabecular bone volume versus vehicle-treated rats.

    In plain wordsIn rats, PTH alone did not significantly increase spine bone volume compared with vehicle.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeVertebral trabecular bone volume
    Study

    ratn: not reported in source

    male Wistar rats
    Comparator
    vehicle-treated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microg/kg daily · injection · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    After 1 month of treatment, the three groups in which PTH was administered (PTH, PTH + E2, and PTH + YM175) had significantly higher trabecular bone volume and connectivity in the proximal tibial metaphyses (PTMs) compared with the untreated and vehicle-treated groups, whereas only combination group…
    1 context sentence
    Summary · context
    The animals were untreated or injected with vehicle, recombinant human PTH(1-84) (PTH; 100 microg/kg daily), 17beta-estradiol (E2, 500 microg/kg every other day), incadronate disodium (YM175, 80 microg/kg every other day), combined PTH and E2 (PTH + E2), or a combination of PTH and YM175 (PTH + YM175).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PTH monotherapy did not significantly increase vertebral trabecular connectivity versus untreated rats.

    In plain wordsIn rats, PTH alone did not significantly increase spine bone connections compared with untreated rats.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeVertebral trabecular connectivity
    Study

    ratn: not reported in source

    male Wistar rats
    Comparator
    untreated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microg/kg daily · injection · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    After 1 month of treatment, the three groups in which PTH was administered (PTH, PTH + E2, and PTH + YM175) had significantly higher trabecular bone volume and connectivity in the proximal tibial metaphyses (PTMs) compared with the untreated and vehicle-treated groups, whereas only combination group…
    1 context sentence
    Summary · context
    The animals were untreated or injected with vehicle, recombinant human PTH(1-84) (PTH; 100 microg/kg daily), 17beta-estradiol (E2, 500 microg/kg every other day), incadronate disodium (YM175, 80 microg/kg every other day), combined PTH and E2 (PTH + E2), or a combination of PTH and YM175 (PTH + YM175).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PTH monotherapy did not significantly increase vertebral trabecular connectivity versus vehicle-treated rats.

    In plain wordsIn rats, PTH alone did not significantly increase spine bone connections compared with vehicle.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeVertebral trabecular connectivity
    Study

    ratn: not reported in source

    male Wistar rats
    Comparator
    vehicle-treated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microg/kg daily · injection · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    After 1 month of treatment, the three groups in which PTH was administered (PTH, PTH + E2, and PTH + YM175) had significantly higher trabecular bone volume and connectivity in the proximal tibial metaphyses (PTMs) compared with the untreated and vehicle-treated groups, whereas only combination group…
    1 context sentence
    Summary · context
    The animals were untreated or injected with vehicle, recombinant human PTH(1-84) (PTH; 100 microg/kg daily), 17beta-estradiol (E2, 500 microg/kg every other day), incadronate disodium (YM175, 80 microg/kg every other day), combined PTH and E2 (PTH + E2), or a combination of PTH and YM175 (PTH + YM175).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PTH significantly increased vertebral bone resorption.

    In plain wordsIn rats, PTH increased spine bone resorption.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseVertebral bone resorption
    Study

    ratn: not reported in source

    male Wistar rats
    Comparator
    control groups
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microg/kg daily · injection · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    This site-related discrepancy was attributed to the fact that PTH significantly elevated bone resorption not in the PTMs but in the vertebrae.
    1 context sentence
    Summary · context
    The animals were untreated or injected with vehicle, recombinant human PTH(1-84) (PTH; 100 microg/kg daily), 17beta-estradiol (E2, 500 microg/kg every other day), incadronate disodium (YM175, 80 microg/kg every other day), combined PTH and E2 (PTH + E2), or a combination of PTH and YM175 (PTH + YM175).
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PTH did not significantly increase proximal tibial bone resorption.

    In plain wordsIn rats, PTH did not significantly increase bone resorption near the shin bone end.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeProximal tibial bone resorption
    Study

    ratn: not reported in source

    male Wistar rats
    Comparator
    control groups
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microg/kg daily · injection · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    This site-related discrepancy was attributed to the fact that PTH significantly elevated bone resorption not in the PTMs but in the vertebrae.
    1 context sentence
    Summary · context
    The animals were untreated or injected with vehicle, recombinant human PTH(1-84) (PTH; 100 microg/kg daily), 17beta-estradiol (E2, 500 microg/kg every other day), incadronate disodium (YM175, 80 microg/kg every other day), combined PTH and E2 (PTH + E2), or a combination of PTH and YM175 (PTH + YM175).
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PTH monotherapy did not significantly increase vertebral mechanical strength above control levels.

    In plain wordsIn male rats, PTH alone did not significantly increase spine bone strength compared with controls.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeVertebral mechanical strength
    Study

    ratn: not reported in source

    male Wistar rats
    Comparator
    control groups
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microg/kg daily · injection · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    As a result, trabecular bone mass, connectivity, and mechanical strength of the vertebrae were significantly increased from control levels only in the concurrent treatment groups (PTH + E2 and PTH + YM175).
    1 context sentence
    Summary · context
    The animals were untreated or injected with vehicle, recombinant human PTH(1-84) (PTH; 100 microg/kg daily), 17beta-estradiol (E2, 500 microg/kg every other day), incadronate disodium (YM175, 80 microg/kg every other day), combined PTH and E2 (PTH + E2), or a combination of PTH and YM175 (PTH + YM175).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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