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Study · Animal study (in vivo) · rat · 1999

2 results

The effect of GH on estrogen receptor expression in the rat mammary gland.

Feldman M, Ruan W, Tappin I, Wieczorek R, Kleinberg DL

The Journal of endocrinology1 Dec 1999Cited by 27 (Europe PMC)

PMID10588825 (opens in a new tab)DOI10.1677/joe.0.1630515 (opens in a new tab)PepBankPUB-10588825
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In operated rats, des(1‑3)-IGF-I did not reproducibly increase mammary estrogen receptor levels.

    In plain wordsIn rats, des(1‑3)-IGF-I did not reproducibly increase mammary estrogen receptor levels.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Direction not reportedEstrogen receptor levels
    Study

    ratn: not reported in source

    Hypophysectomized and oophorectomized rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, treating animals with des(1-3)-IGF-I did not result in reproducible increases in ER, nor in the staining of fat cell nuclei for ER.
    1 context sentence
    Summary · context
    ER levels in the mammary gland cytosols from hypophysectomized and oophorectomized rats, were measured using two assay systems: a dextran-coated charcoal procedure to measure binding to radiolabeled steroid, and an immunologic assay employing a specific antibody to the receptor.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In operated rats, des(1‑3)-IGF-I did not produce estrogen receptor staining in fat cell nuclei.

    In plain wordsIn rats, des(1‑3)-IGF-I did not produce estrogen receptor staining in fat cell nuclei.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Direction not reportedEstrogen receptor staining in fat cell nuclei
    Study

    ratn: not reported in source

    Hypophysectomized and oophorectomized rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, treating animals with des(1-3)-IGF-I did not result in reproducible increases in ER, nor in the staining of fat cell nuclei for ER.
    1 context sentence
    Summary · context
    ER levels in the mammary gland cytosols from hypophysectomized and oophorectomized rats, were measured using two assay systems: a dextran-coated charcoal procedure to measure binding to radiolabeled steroid, and an immunologic assay employing a specific antibody to the receptor.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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