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Study · Not a test of the peptide alone · 1999

6 results

Chemical syntheses and biological studies on dimeric chimeras of oxytocin and the V(2)-antagonist, d(CH(2))(5)[D-Ile(2), Ile(4)]arginine vasopressin.

Chen L, Golser R, Machová A, Slaninová J, Barany G

Journal of medicinal chemistry1 Dec 1999Cited by 3 (Europe PMC)

PMID10585209 (opens in a new tab)DOI10.1021/jm9900220 (opens in a new tab)PepBankPUB-10585209
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Activity measurement

    Parallel and antiparallel oxytocin and V2-antagonist chimeras lacked pressor activity.

    In plain wordsBoth oxytocin and V2-antagonist chimeras showed no pressor activity in the tests.

    Peptide
    Oxytocin
    Outcome
    No significant changePressor activity of the chimeras
    Study

    n: not reported in source

    Outcome group
    Blood pressure · Cardiovascular

    Source sentences

    Summary
    Biological studies revealed that both the parallel and antiparallel chimeras lack pressor activity, have low uterotonic activity, and have diuretic activities comparable to that of the monomeric V(2)-antagonist.
    1 context sentence
    Summary · context
    Parallel and antiparallel heterodimers have been synthesized that combine into a single molecule the neurohypophyseal hormone oxytocin and the potent vasopressin V(2)-antagonist d(CH(2))(5)[D-Ile(2), Ile(4)]arginine vasopressin.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Activity measurement

    Parallel and antiparallel oxytocin and V2-antagonist chimeras had low uterotonic activity.

    In plain wordsBoth chimeras showed low uterus-contracting activity in the tests.

    Peptide
    Oxytocin
    Outcome
    Not applicableUterotonic activity of the chimeras
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Biological studies revealed that both the parallel and antiparallel chimeras lack pressor activity, have low uterotonic activity, and have diuretic activities comparable to that of the monomeric V(2)-antagonist.
    1 context sentence
    Summary · context
    Parallel and antiparallel heterodimers have been synthesized that combine into a single molecule the neurohypophyseal hormone oxytocin and the potent vasopressin V(2)-antagonist d(CH(2))(5)[D-Ile(2), Ile(4)]arginine vasopressin.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Activity measurement

    The chimeras had diuretic activities comparable to that of the monomeric V2-antagonist.

    In plain wordsBoth chimeras had urine-increasing activity similar to the V2-antagonist alone.

    Peptide
    Oxytocin
    Outcome
    No significant changeDiuretic activity of the chimeras
    Study

    n: not reported in source

    Comparator
    Monomeric V2-antagonist
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    Biological studies revealed that both the parallel and antiparallel chimeras lack pressor activity, have low uterotonic activity, and have diuretic activities comparable to that of the monomeric V(2)-antagonist.
    1 context sentence
    Summary · context
    Parallel and antiparallel heterodimers have been synthesized that combine into a single molecule the neurohypophyseal hormone oxytocin and the potent vasopressin V(2)-antagonist d(CH(2))(5)[D-Ile(2), Ile(4)]arginine vasopressin.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Activity measurement

    With a 4% water load, both chimeras acted like an equimolar mixture of oxytocin and V2-antagonist: sodium excretion was lower than with oxytocin alone and higher than with V2-antagonist alone.

    In plain wordsWith a water load, the chimeras lowered sodium excretion compared with oxytocin alone but raised it compared with the V2-antagonist alone.

    Peptide
    Oxytocin
    Outcome
    MixedSodium excretion with 4% water load
    Study

    n: not reported in source

    Comparator
    Oxytocin alone; V2-antagonist alone; equimolar mixture
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    Thus, with a 4% water load, both chimeras display effects similar to that of an equimolar mixture of oxytocin and V(2)-antagonist, i.e., lower sodium excretion than that resulting from administration of oxytocin alone but higher than that when V(2)-antagonist was administered alone.
    1 context sentence
    Summary · context
    Parallel and antiparallel heterodimers have been synthesized that combine into a single molecule the neurohypophyseal hormone oxytocin and the potent vasopressin V(2)-antagonist d(CH(2))(5)[D-Ile(2), Ile(4)]arginine vasopressin.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  5. 05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Activity measurement

    Without a water load, the parallel chimera promoted sodium excretion more than oxytocin alone or an equimolar mixture of oxytocin and V2-antagonist.

    In plain wordsWithout a water load, the parallel chimera raised sodium excretion more than oxytocin alone or a mix of the two parts.

    Peptide
    Oxytocin
    Outcome
    IncreaseSodium excretion without water load
    Study

    n: not reported in source

    Comparator
    Oxytocin alone; equimolar mixture of oxytocin and V2-antagonist
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    However, when no water load was used, the parallel chimera proved to be more effective in promoting sodium excretion than either oxytocin alone or an equimolar mixture of oxytocin and V(2)-antagonist.
    1 context sentence
    Summary · context
    Parallel and antiparallel heterodimers have been synthesized that combine into a single molecule the neurohypophyseal hormone oxytocin and the potent vasopressin V(2)-antagonist d(CH(2))(5)[D-Ile(2), Ile(4)]arginine vasopressin.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  6. 06LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    A directed disulfide strategy formed the first bridge of the oxytocin and V2-antagonist heterodimers; the inverse directed strategy failed because of steric hindrance.

    In plain wordsIn lab chemistry, a directed method joined the two peptide halves in one direction, and the reverse method failed.

    Peptide
    Oxytocin
    Outcome
    Not applicableSynthesis of oxytocin and V2-antagonist heterodimers
    Study

    n: not reported in source

    Outcome group
    Synthesis and manufacturing · Pharmacology

    Source sentences

    Summary
    The first disulfide bridge was formed by a directed approach involving attack by the free thiol of the 1-beta-mercapto-beta, beta-cyclopentamethylenepropionic acid (Pmp) residue of one monomer onto the Snm group of a cysteine residue on the other monomer; the inverse directed strategy failed due to steric hindrance.
    1 context sentence
    Summary · context
    Parallel and antiparallel heterodimers have been synthesized that combine into a single molecule the neurohypophyseal hormone oxytocin and the potent vasopressin V(2)-antagonist d(CH(2))(5)[D-Ile(2), Ile(4)]arginine vasopressin.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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