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Study · Animal study (in vivo) · rat · 1999

3 results

In vivo upregulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived peptides.

Boado RJ, Wu D, Windisch M

Neuroscience research1 Sept 1999Cited by 28 (Europe PMC)

PMID10576544 (opens in a new tab)DOI10.1016/s0168-0102(99)00056-5 (opens in a new tab)PepBankPUB-10576544
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, acute or chronic Cerebrolysin increased brain glucose permeability surface area versus controls.

    In plain wordsIn rats, Cerebrolysin increased glucose transport into the brain compared with controls.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBrain glucose permeability surface area
    Study

    ratn: not reported in source

    Blood-brain barrier glucose transport
    Comparator
    Controls
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Frontal cortex glucose transport increase
    1.6 to 1.9 fold
    versus controls

    Source sentences

    Summary
    The acute or chronic administration of C1 markedly increased the brain permeability surface area of D-[14C]glucose compared to controls (D-[14C]glucose/[3H]diazepam ratio, 1.6- to 1.9-fold increase in frontal cortex, P < 0.05).
    2 context sentences
    Summary · context
    The aim of the present investigation was to determine if C1 induces similar changes in the expression of the BBB-GLUT1 gene following its administration to rats in vivo.
    Summary · context
    The BBB glucose transporter activity was investigated with the intracarotid artery perfusion technique using [3H]diazepam as cerebral blood flow marker.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, increased glucose transporter activity after Cerebrolysin correlated with increased BBB-GLUT1 protein abundance.

    In plain wordsIn rats, increased glucose transport after Cerebrolysin was linked to more transporter protein.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBBB-GLUT1 protein abundance
    Study

    ratn: not reported in source

    Blood-brain barrier glucose transport
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Increased activity of the BBB glucose transporter was correlated with a significant rise in the abundance of the BBB-GLUT1 protein measured by both Western blot analysis and immunocytochemistry, and with a decrease in the transcript levels of this transporter.
    2 context sentences
    Summary · context
    The aim of the present investigation was to determine if C1 induces similar changes in the expression of the BBB-GLUT1 gene following its administration to rats in vivo.
    Summary · context
    The BBB glucose transporter activity was investigated with the intracarotid artery perfusion technique using [3H]diazepam as cerebral blood flow marker.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, increased glucose transporter activity after Cerebrolysin correlated with decreased transporter transcript levels.

    In plain wordsIn rats, increased glucose transport after Cerebrolysin was linked to lower transporter transcript levels.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBBB-GLUT1 transcript levels
    Study

    ratn: not reported in source

    Blood-brain barrier glucose transport
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Increased activity of the BBB glucose transporter was correlated with a significant rise in the abundance of the BBB-GLUT1 protein measured by both Western blot analysis and immunocytochemistry, and with a decrease in the transcript levels of this transporter.
    2 context sentences
    Summary · context
    The aim of the present investigation was to determine if C1 induces similar changes in the expression of the BBB-GLUT1 gene following its administration to rats in vivo.
    Summary · context
    The BBB glucose transporter activity was investigated with the intracarotid artery perfusion technique using [3H]diazepam as cerebral blood flow marker.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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