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Study · Animal study (in vivo) · mouse · 1999

8 results

Effects of thymulin on spontaneous puberty and gonadotrophin-induced ovulation in prepubertal normal and hypothymic mice.

Hinojosa L, Chavira R, Domínguez R, Rosas P

The Journal of endocrinology1 Nov 1999Cited by 13 (Europe PMC)

PMID10556775 (opens in a new tab)DOI10.1677/joe.0.1630255 (opens in a new tab)PepBankPUB-10556775
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In normal and hypothymic mice, daily thymulin beginning at the later age delayed vaginal opening.

    In plain wordsIn normal and hypothymic mice, daily thymulin beginning at the later age delayed vaginal opening.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseAge of vaginal opening
    Study

    mousen: not reported in source

    normal and hypothymic prepubertal female mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In normal and hypothymic mice, the daily administration of thymulin at 24 days of age resulted in a delay in the age of vaginal opening, with an increase in serum progesterone levels.
    1 context sentence
    Summary · context
    The effects of thymulin administration beginning on days 19 or 24 of age on spontaneous puberty and gonadotrophin-induced ovulation were analysed in female normal and hypothymic mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In normal and hypothymic mice, daily thymulin beginning at the later age increased serum progesterone.

    In plain wordsIn normal and hypothymic mice, daily thymulin beginning at the later age increased blood progesterone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseSerum progesterone
    Study

    mousen: not reported in source

    normal and hypothymic prepubertal female mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In normal and hypothymic mice, the daily administration of thymulin at 24 days of age resulted in a delay in the age of vaginal opening, with an increase in serum progesterone levels.
    1 context sentence
    Summary · context
    The effects of thymulin administration beginning on days 19 or 24 of age on spontaneous puberty and gonadotrophin-induced ovulation were analysed in female normal and hypothymic mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In hypothymic mice given PMSG on day 25, prior thymulin reduced ova shed among ovulating animals versus PMSG alone.

    In plain wordsIn hypothymic mice that ovulated after PMSG, prior thymulin reduced eggs released compared with PMSG alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseOva shed in hypothymic mice treated later
    Study

    mousen: not reported in source

    hypothymic prepubertal female mice
    Comparator
    PMSG alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 ngAs given in this study (mouse).

    Source sentences

    Summary
    When these animals were injected previously with 200 ng thymulin, the number of ova shed by ovulating animals was lower than in PMSG-treated animals.
    2 context sentences
    Summary · context
    PMSG treatment on day 25 induced ovulation in hypothymic mice.
    Summary · context
    The effects of thymulin administration beginning on days 19 or 24 of age on spontaneous puberty and gonadotrophin-induced ovulation were analysed in female normal and hypothymic mice.

Studies that did not test the peptide alone5

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 04AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In normal mice, thymulin followed by PMSG increased ovulation rate.

    In plain wordsIn normal mice, thymulin followed by PMSG increased ovulation rate.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseOvulation rate in normal mice
    Study

    mousen: not reported in source

    normal prepubertal female mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Normal mice treated with 200 ng thymulin beginning on day 19 of age and injected with pregnant mare serum gonadotrophin (PMSG) 24 h later had an increase in ovulation rate, number of ova shed and weight of the ovaries.
    1 context sentence
    Summary · context
    The effects of thymulin administration beginning on days 19 or 24 of age on spontaneous puberty and gonadotrophin-induced ovulation were analysed in female normal and hypothymic mice.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 05AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In normal mice, thymulin followed by PMSG increased the number of ova shed.

    In plain wordsIn normal mice, thymulin followed by PMSG increased the number of eggs released.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseOva shed in normal mice
    Study

    mousen: not reported in source

    normal prepubertal female mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Normal mice treated with 200 ng thymulin beginning on day 19 of age and injected with pregnant mare serum gonadotrophin (PMSG) 24 h later had an increase in ovulation rate, number of ova shed and weight of the ovaries.
    1 context sentence
    Summary · context
    The effects of thymulin administration beginning on days 19 or 24 of age on spontaneous puberty and gonadotrophin-induced ovulation were analysed in female normal and hypothymic mice.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 06AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In normal mice, thymulin followed by PMSG increased ovarian weight.

    In plain wordsIn normal mice, thymulin followed by PMSG increased ovarian weight.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseOvarian weight in normal mice
    Study

    mousen: not reported in source

    normal prepubertal female mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Normal mice treated with 200 ng thymulin beginning on day 19 of age and injected with pregnant mare serum gonadotrophin (PMSG) 24 h later had an increase in ovulation rate, number of ova shed and weight of the ovaries.
    1 context sentence
    Summary · context
    The effects of thymulin administration beginning on days 19 or 24 of age on spontaneous puberty and gonadotrophin-induced ovulation were analysed in female normal and hypothymic mice.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 07AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In hypothymic mice treated early with thymulin and PMSG, no animals ovulated.

    In plain wordsIn hypothymic mice treated early with thymulin and PMSG, no animals released eggs.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableOvulation in hypothymic mice treated early
    Study

    mousen: not reported in source

    hypothymic prepubertal female mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    None of the hypothymic mice treated with thymulin on day 19 and PMSG on day 20 ovulated.
    1 context sentence
    Summary · context
    The effects of thymulin administration beginning on days 19 or 24 of age on spontaneous puberty and gonadotrophin-induced ovulation were analysed in female normal and hypothymic mice.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  5. 08AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In mice, thymulin with sequential PMSG and hCG increased ovulatory response versus PMSG alone.

    In plain wordsIn mice, thymulin with PMSG and hCG increased ovulatory response compared with PMSG alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseOvulatory response with sequential gonadotropins
    Study

    mousen: not reported in source

    normal and hypothymic prepubertal female mice
    Comparator
    PMSG alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Administration of thymulin and sequential injection of PMSG and human chorionic gonadotrophin 54 h later resulted in an increase in ovulatory response in comparison with those receiving only PMSG.
    1 context sentence
    Summary · context
    The effects of thymulin administration beginning on days 19 or 24 of age on spontaneous puberty and gonadotrophin-induced ovulation were analysed in female normal and hypothymic mice.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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