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Study · In vitro (cells) · 1999

1 result

Modulation of human cytotrophoblastic leptin secretion by interleukin-1alpha and 17beta-oestradiol and its effect on HCG secretion.

Chardonnens D, Cameo P, Aubert ML, Pralong FP, Islami D, Campana A, Gaillard RC, Bischof P

Molecular human reproduction1 Nov 1999Cited by 70 (Europe PMC)

PMID10541571 (opens in a new tab)DOI10.1093/molehr/5.11.1077 (opens in a new tab)PepBankPUB-10541571
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human cytotrophoblastic cells, cetrorelix inhibited leptin-induced HCG secretion (P = 0.0028).

    In plain wordsIn cells, cetrorelix reduced leptin-induced HCG release compared with leptin stimulation without cetrorelix.

    Peptide
    Cetrorelix
    Outcome
    DecreaseLeptin-induced HCG secretion
    Study

    humann: not reported in source

    First-trimester placental cytotrophoblastic cells
    Comparator
    Leptin stimulation without cetrorelix
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.1 microg/mlAs given in this study (human).

    Source sentences

    Summary
    Cetrorelix (0.1 microg/ml) inhibited leptin-induced HCG secretion (P = 0.0028).
    2 context sentences
    Summary · context
    To investigate the role of leptin during pregnancy, we assessed leptin production by pure cultured human cytotrophoblastic cells (CTB), its regulation by cytokines and 17beta-oestradiol and its effects on human chorionic gonadotrophin (HCG) secretion.
    Summary · context
    Purified CTB from first trimester placenta were incubated in duplicates in the presence or absence of cytokines or 17beta-oestradiol.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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