In cultured fetal sheep growth plate chondrocytes, Long R3 IGF-I was more potent than native IGF-I in promoting DNA synthesis.
In plain wordsIn lab tests on sheep cartilage cells, an IGF-I analogue boosted DNA synthesis more than natural IGF-I.
- Peptide
- IGF-1 LR3
- Outcome
- IncreaseDNA synthesis in chondrocytes
- Study
sheepn: not reported in source
Monolayer chondrocyte cultures from fetal ovine growth plate- Comparator
- Native IGF-I
- Outcome group
- Bone and joint · Musculoskeletal
- Studied dose
- Dose not stated
Source sentences
Long R3 IGF-I, which has a reduced binding affinity for many IGFBPs, was more potent than native IGF-I in promoting DNA synthesis by chondrocytes.
1 context sentence(design, population, supporting numbers)
To test this hypothesis, monolayer cultures of chondrocytes were established from the proliferative zone of the growth plate, and were found to release immunoreactive IGF-II and to express mRNAs encoding IGFBP-2 to -6.