Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys.

Brommage R, Hotchkiss CE, Lees CJ, Stancill MW, Hock JM, Jerome CP

The Journal of clinical endocrinology and metabolism1 Oct 1999Cited by 59 (Europe PMC)

PMID10523026DOI10.1210/jcem.84.10.6039PepBankPUB-10523026

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In monkeys, rhPTH did not influence serum ionized calcium.
In plain wordsIn monkeys, rhPTH did not affect blood ionized calcium compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeSerum ionized calcium
Study
Macaca fascicularisn: not reported in source
Ovariectomized adult female monkeys
Comparator
OVX vehicle
Outcome group
Adverse events · Endocrine and hormones
Studied dose
Dose not stated · subcutaneous · 12 monthsAs given in this study (Macaca fascicularis).
Source sentences
Summary
Serum and urine samples were also analyzed. rhPTH-(1-34) treatment did not influence serum ionized Ca levels or urinary Ca excretion, but depressed endogenous PTH while increasing serum calcitriol levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Adult female cynomolgus monkeys were divided into sham-vehicle (n = 21), ovariectomized (OVX)-vehicle (n = 20), and OVX groups given daily s.c. injections of rhPTH-(1-34) at 1 (n = 39) or 5 (n = 41) microg/kg for 12 months.
Report a problemFND-1052302601
02AnimalAnimal study (in vivo)Efficacy outcome
In monkeys, rhPTH did not influence urinary calcium excretion.
In plain wordsIn monkeys, rhPTH did not affect urine calcium excretion compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeUrinary calcium excretion
Study
Macaca fascicularisn: not reported in source
Ovariectomized adult female monkeys
Comparator
OVX vehicle
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · subcutaneous · 12 monthsAs given in this study (Macaca fascicularis).
Source sentences
Summary
Serum and urine samples were also analyzed. rhPTH-(1-34) treatment did not influence serum ionized Ca levels or urinary Ca excretion, but depressed endogenous PTH while increasing serum calcitriol levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Adult female cynomolgus monkeys were divided into sham-vehicle (n = 21), ovariectomized (OVX)-vehicle (n = 20), and OVX groups given daily s.c. injections of rhPTH-(1-34) at 1 (n = 39) or 5 (n = 41) microg/kg for 12 months.
Report a problemFND-1052302602
03AnimalAnimal study (in vivo)Mechanism
In monkeys, administered rhPTH depressed endogenous PTH.
In plain wordsIn monkeys, administered rhPTH reduced the body's own PTH compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseEndogenous PTH
Study
Macaca fascicularisn: not reported in source
Ovariectomized adult female monkeys
Comparator
OVX vehicle
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated · subcutaneous · 12 monthsAs given in this study (Macaca fascicularis).
Source sentences
Summary
Serum and urine samples were also analyzed. rhPTH-(1-34) treatment did not influence serum ionized Ca levels or urinary Ca excretion, but depressed endogenous PTH while increasing serum calcitriol levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Adult female cynomolgus monkeys were divided into sham-vehicle (n = 21), ovariectomized (OVX)-vehicle (n = 20), and OVX groups given daily s.c. injections of rhPTH-(1-34) at 1 (n = 39) or 5 (n = 41) microg/kg for 12 months.
Report a problemFND-1052302603
04AnimalAnimal study (in vivo)Mechanism
In monkeys, rhPTH increased serum calcitriol.
In plain wordsIn monkeys, rhPTH increased blood calcitriol compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSerum calcitriol
Study
Macaca fascicularisn: not reported in source
Ovariectomized adult female monkeys
Comparator
OVX vehicle
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated · subcutaneous · 12 monthsAs given in this study (Macaca fascicularis).
Source sentences
Summary
Serum and urine samples were also analyzed. rhPTH-(1-34) treatment did not influence serum ionized Ca levels or urinary Ca excretion, but depressed endogenous PTH while increasing serum calcitriol levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Adult female cynomolgus monkeys were divided into sham-vehicle (n = 21), ovariectomized (OVX)-vehicle (n = 20), and OVX groups given daily s.c. injections of rhPTH-(1-34) at 1 (n = 39) or 5 (n = 41) microg/kg for 12 months.
Report a problemFND-1052302604
05AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized monkeys, higher-dose rhPTH increased spine BMD versus OVX vehicle.
In plain wordsIn monkeys, higher-dose rhPTH increased spine bone density versus OVX vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSpine BMD
Study
Macaca fascicularisn: not reported in source
Ovariectomized adult female monkeys
Comparator
OVX vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 microg/kg daily · subcutaneous · 12 monthsAs given in this study (Macaca fascicularis).
Measurements
Spine BMD increase
14.3%
higher dose versus OVX
Source sentences
Summary
Compared to that in the OVX group, the higher dose of rhPTH-(1-34) increased spine BMD by 14.3%, whole body bone mineral content by 8.6%, and proximal tibia BMD by 10.8%.
1 context sentence(design, population, supporting numbers)
Summary · context
Adult female cynomolgus monkeys were divided into sham-vehicle (n = 21), ovariectomized (OVX)-vehicle (n = 20), and OVX groups given daily s.c. injections of rhPTH-(1-34) at 1 (n = 39) or 5 (n = 41) microg/kg for 12 months.
Report a problemFND-1052302605
06AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized monkeys, higher-dose rhPTH increased whole-body bone mineral content versus OVX vehicle.
In plain wordsIn monkeys, higher-dose rhPTH increased whole-body bone mineral content versus OVX vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseWhole-body bone mineral content
Study
Macaca fascicularisn: not reported in source
Ovariectomized adult female monkeys
Comparator
OVX vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 microg/kg daily · subcutaneous · 12 monthsAs given in this study (Macaca fascicularis).
Measurements
Bone mineral content increase
8.6%
higher dose versus OVX
Source sentences
Summary
Compared to that in the OVX group, the higher dose of rhPTH-(1-34) increased spine BMD by 14.3%, whole body bone mineral content by 8.6%, and proximal tibia BMD by 10.8%.
1 context sentence(design, population, supporting numbers)
Summary · context
Adult female cynomolgus monkeys were divided into sham-vehicle (n = 21), ovariectomized (OVX)-vehicle (n = 20), and OVX groups given daily s.c. injections of rhPTH-(1-34) at 1 (n = 39) or 5 (n = 41) microg/kg for 12 months.
Report a problemFND-1052302606
07AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized monkeys, higher-dose rhPTH increased proximal tibia BMD versus OVX vehicle.
In plain wordsIn monkeys, higher-dose rhPTH increased upper tibia bone density versus OVX vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseProximal tibia BMD
Study
Macaca fascicularisn: not reported in source
Ovariectomized adult female monkeys
Comparator
OVX vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 microg/kg daily · subcutaneous · 12 monthsAs given in this study (Macaca fascicularis).
Measurements
Proximal tibia BMD increase
10.8%
higher dose versus OVX
Source sentences
Summary
Compared to that in the OVX group, the higher dose of rhPTH-(1-34) increased spine BMD by 14.3%, whole body bone mineral content by 8.6%, and proximal tibia BMD by 10.8%.
1 context sentence(design, population, supporting numbers)
Summary · context
Adult female cynomolgus monkeys were divided into sham-vehicle (n = 21), ovariectomized (OVX)-vehicle (n = 20), and OVX groups given daily s.c. injections of rhPTH-(1-34) at 1 (n = 39) or 5 (n = 41) microg/kg for 12 months.
Report a problemFND-1052302607
08AnimalAnimal study (in vivo)Mechanism
In monkeys, subregion analyses suggested that the proximal tibial anabolic effect of rhPTH was primarily cancellous.
In plain wordsIn monkeys, rhPTH appeared to act mainly on spongy bone in the upper tibia.
Peptide
Teriparatide (PTH 1-34)
Outcome
Not applicableProximal tibial anabolic localization
Study
Macaca fascicularisn: not reported in source
Ovariectomized adult female monkeys
Comparator
OVX vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous · 12 monthsAs given in this study (Macaca fascicularis).
Source sentences
Summary
Subregion analyses suggested that the anabolic effect of rhPTH-(1-34) on the proximal tibia was primarily in cancellous bone.
1 context sentence(design, population, supporting numbers)
Summary · context
Adult female cynomolgus monkeys were divided into sham-vehicle (n = 21), ovariectomized (OVX)-vehicle (n = 20), and OVX groups given daily s.c. injections of rhPTH-(1-34) at 1 (n = 39) or 5 (n = 41) microg/kg for 12 months.
Report a problemFND-1052302608
09AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized monkeys, lower-dose rhPTH produced BMD increases similar to, but smaller than, those with the higher dose.
In plain wordsIn ovariectomized monkeys, lower-dose rhPTH increased bone density compared with vehicle, with smaller effects than the higher dose.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBMD at lower dose
Study
Macaca fascicularisn: not reported in source
Ovariectomized adult female monkeys
Comparator
OVX vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
1 microg/kg daily · subcutaneous · 12 monthsAs given in this study (Macaca fascicularis).
Source sentences
Summary
Similar, but less dramatic, effects on BMD were observed with the lower dose of rhPTH-(1-34).
1 context sentence(design, population, supporting numbers)
Summary · context
Adult female cynomolgus monkeys were divided into sham-vehicle (n = 21), ovariectomized (OVX)-vehicle (n = 20), and OVX groups given daily s.c. injections of rhPTH-(1-34) at 1 (n = 39) or 5 (n = 41) microg/kg for 12 months.
Report a problemFND-1052302609

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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