Skip to content

Study · Animal study (in vivo) · macaca fascicularis · 1999

18 results

Effect of treatment for 6 months with human parathyroid hormone (1-34) peptide in ovariectomized cynomolgus monkeys (Macaca fascicularis).

Jerome CP, Johnson CS, Vafai HT, Kaplan KC, Bailey J, Capwell B, Fraser F, Hansen L, Ramsay H, Shadoan M, Lees CJ, Thomsen JS, Mosekilde L

Bone1 Sept 1999Cited by 44 (Europe PMC)

PMID10495134 (opens in a new tab)DOI10.1016/s8756-3282(99)00166-0 (opens in a new tab)PepBankPUB-10495134
Publisher pagePubMedAsk about this study
Jump to 18 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study18

18 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized monkeys, PTH did not change whole-body bone mass versus placebo.

    In plain wordsIn monkeys, PTH did not change whole-body bone mass versus placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeWhole-body bone mass
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Compared with placebo-treated animals, PTH-treated monkeys had no change in whole-body bone mass, but a 6.7% increase in spinal areal bone mineral density (aBMD) was observed.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized monkeys, PTH increased spinal areal BMD versus placebo.

    In plain wordsIn monkeys, PTH increased spine bone density versus placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSpinal areal BMD
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Measurements

    Spinal aBMD increase
    6.7%
    PTH versus placebo

    Source sentences

    Summary
    Compared with placebo-treated animals, PTH-treated monkeys had no change in whole-body bone mass, but a 6.7% increase in spinal areal bone mineral density (aBMD) was observed.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, PTH did not affect appendicular cortical bone mass versus placebo.

    In plain wordsIn monkeys, PTH did not affect limb cortical bone mass versus placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeAppendicular cortical bone mass
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Cortical bone mass measured by qCT at appendicular sites was not affected by PTH treatment, but there were significant increases in cancellous bone mass in the proximal tibia, and a similar trend in the distal radius.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, PTH significantly increased proximal tibial cancellous bone mass versus placebo.

    In plain wordsIn monkeys, PTH increased spongy bone mass in the upper tibia versus placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseProximal tibial cancellous bone mass
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Cortical bone mass measured by qCT at appendicular sites was not affected by PTH treatment, but there were significant increases in cancellous bone mass in the proximal tibia, and a similar trend in the distal radius.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, distal radius cancellous bone mass showed an upward trend with PTH versus placebo.

    In plain wordsIn monkeys, spongy bone mass in the lower radius tended to increase with PTH versus placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseDistal radius cancellous bone mass
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Cortical bone mass measured by qCT at appendicular sites was not affected by PTH treatment, but there were significant increases in cancellous bone mass in the proximal tibia, and a similar trend in the distal radius.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    In monkeys, PTH produced small transient serum calcium increases.

    In plain wordsIn monkeys, PTH caused small temporary increases in blood calcium compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSerum calcium
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Adverse events · Endocrine and hormones
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Small, transient increases in serum and urinary calcium were observed, but there were no treatment-related effects on other biochemical endpoints.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  7. 07AnimalAnimal study (in vivo)Safety outcome

    In monkeys, PTH produced small transient urinary calcium increases.

    In plain wordsIn monkeys, PTH caused small temporary increases in urine calcium compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseUrinary calcium
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Small, transient increases in serum and urinary calcium were observed, but there were no treatment-related effects on other biochemical endpoints.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, PTH had no treatment-related effects on other measured biochemical endpoints.

    In plain wordsIn monkeys, PTH did not affect the other measured blood and urine markers compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeOther biochemical endpoints
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Small, transient increases in serum and urinary calcium were observed, but there were no treatment-related effects on other biochemical endpoints.
    3 context sentences
    Summary · context
    analysis of serum (calcium, phosphorus, alkaline phosphatase, osteocalcin, and tartrate-resistant acid phosphatase) and urinary (calcium and creatinine) biomarkers
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, PTH increased midradius bone formation rate.

    In plain wordsIn monkeys, PTH increased bone formation in the middle radius compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMidradius bone formation rate
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Increased bone formation rate (BFR/BV) in the midradius and midfemur was accompanied by a nonsignificant increase in midfemur porosity.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, PTH increased midfemur bone formation rate.

    In plain wordsIn monkeys, PTH increased bone formation in the middle femur compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMidfemur bone formation rate
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Increased bone formation rate (BFR/BV) in the midradius and midfemur was accompanied by a nonsignificant increase in midfemur porosity.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, the increase in midfemur porosity with PTH was not significant.

    In plain wordsIn monkeys, the increase in middle femur porosity with PTH was not significant compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeMidfemur porosity
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Increased bone formation rate (BFR/BV) in the midradius and midfemur was accompanied by a nonsignificant increase in midfemur porosity.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, PTH increased vertebral cancellous bone volume.

    In plain wordsIn monkeys, PTH increased spongy bone volume in the vertebrae compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseVertebral cancellous bone volume
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Increased vertebral cancellous bone volume (BV/TV) was associated with greater trabecular and interstitial thickness with no effect on wall thickness.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, increased vertebral cancellous bone volume accompanied greater trabecular thickness after PTH.

    In plain wordsIn monkeys, PTH increased vertebral spongy bone volume with thicker trabeculae compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular thickness
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Increased vertebral cancellous bone volume (BV/TV) was associated with greater trabecular and interstitial thickness with no effect on wall thickness.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, increased vertebral cancellous bone volume accompanied greater interstitial thickness after PTH.

    In plain wordsIn monkeys, PTH increased vertebral spongy bone volume with greater interstitial thickness compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseInterstitial thickness
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Increased vertebral cancellous bone volume (BV/TV) was associated with greater trabecular and interstitial thickness with no effect on wall thickness.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  15. 15AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, PTH had no effect on wall thickness.

    In plain wordsIn monkeys, PTH did not affect bone wall thickness compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeWall thickness
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Increased vertebral cancellous bone volume (BV/TV) was associated with greater trabecular and interstitial thickness with no effect on wall thickness.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  16. 16AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, PTH increased vertebral maximum stress.

    In plain wordsIn monkeys, PTH increased the maximum stress that vertebrae tolerated compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseVertebral maximum stress
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Increases in bone strength were observed in both axial (vertebral maximum stress and load at fracture) and appendicular (femoral neck fracture load) skeleton.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  17. 17AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, PTH increased vertebral load at fracture.

    In plain wordsIn monkeys, vertebrae tolerated greater fracture loads after PTH compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseVertebral load at fracture
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Increases in bone strength were observed in both axial (vertebral maximum stress and load at fracture) and appendicular (femoral neck fracture load) skeleton.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.
  18. 18AnimalAnimal study (in vivo)Efficacy outcome

    In monkeys, PTH increased femoral neck fracture load.

    In plain wordsIn monkeys, femoral necks tolerated greater fracture loads after PTH compared with placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseFemoral neck fracture load
    Study

    Macaca fascicularisn: not reported in source

    Ovariectomized female cynomolgus monkeys
    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 3 days/week · subcutaneous · 6 monthsAs given in this study (Macaca fascicularis).

    Source sentences

    Summary
    Increases in bone strength were observed in both axial (vertebral maximum stress and load at fracture) and appendicular (femoral neck fracture load) skeleton.
    2 context sentences
    Summary · context
    Ovariectomized, young adult female cynomolgus monkeys were assigned to placebo (n = 9) or PTH groups (n = 10).
    Summary · context
    The PTH group received 10 microg/kg synthetic human PTH(1-34) peptide by subcutaneous injection, 3 days/week for 6 months, and the placebo group received vehicle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.