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Study · In vitro (cells) · bovine · 1999

9 results

GHRP-6 in heifer and cow adenohypophisial cells separated by elutriation.

Rico M, Lorenzo MT, Pazo JA, Vega FV, De la Cruz LF

Journal of physiology and biochemistry1 Mar 1999Cited by 1 (Europe PMC)

PMID10494658 (opens in a new tab)DOI10.1007/bf03655604 (opens in a new tab)PepBankPUB-10494658
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In bovine pituitary cells, GHRP‑6 stimulated GH release, with maximal stimulation at 10(-6) M.

    In plain wordsIn lab tests, GHRP‑6 stimulated growth hormone release from bovine pituitary cells.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH release
    Study

    bovinen: not reported in source

    elutriated heifer and cow adenohypophysial cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-8) M to 10(-5) MAs given in this study (bovine).

    Source sentences

    Summary
    The administration of GHRP-6 at doses from 10(-8) M to 10(-5) M stimulated GH release, and also 10(-9) M in cow pituitary cells, and produced maximal stimulation at 10(-6) M.
    1 context sentence
    Summary · context
    In the present study, the in vitro effects of GHRP-6 on bovine somatotropes separated by elutriation were analyzed as well as its interactions with the GH-releasing hormone (GHRH).
  2. 02LabIn vitro (cells)Efficacy outcome

    In cow pituitary cells, GHRP‑6 also stimulated GH release at 10(-9) M.

    In plain wordsIn lab tests, GHRP‑6 stimulated growth hormone release from cow pituitary cells at the lower concentration.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH release
    Study

    bovinen: not reported in source

    cow pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-9) MAs given in this study (bovine).

    Source sentences

    Summary
    The administration of GHRP-6 at doses from 10(-8) M to 10(-5) M stimulated GH release, and also 10(-9) M in cow pituitary cells, and produced maximal stimulation at 10(-6) M.
    1 context sentence
    Summary · context
    In the present study, the in vitro effects of GHRP-6 on bovine somatotropes separated by elutriation were analyzed as well as its interactions with the GH-releasing hormone (GHRH).
  3. 03LabIn vitro (cells)Efficacy outcome

    In cow pituitary cells, GHRP‑6 significantly stimulated GH release at all reported incubation times.

    In plain wordsIn lab tests, GHRP‑6 increased growth hormone release from cow pituitary cells at all reported times.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH release
    Study

    bovinen: not reported in source

    cow pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-6) M · 1, 2, 3 and 4 hoursAs given in this study (bovine).

    Source sentences

    Summary
    The effects of GHRP-6 (10(-6) M) on GH release were shown at 1, 2, 3 and 4-h incubation (p 0.05).
    1 context sentence
    Summary · context
    In the present study, the in vitro effects of GHRP-6 on bovine somatotropes separated by elutriation were analyzed as well as its interactions with the GH-releasing hormone (GHRH).
  4. 04LabIn vitro (cells)Efficacy outcome

    In heifer pituitary cells, GHRP‑6 significantly stimulated GH release after the first incubation hour.

    In plain wordsIn lab tests, GHRP‑6 increased growth hormone release from heifer pituitary cells after the first incubation hour.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH release
    Study

    bovinen: not reported in source

    heifer pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-6) M · 2, 3 and 4 hoursAs given in this study (bovine).

    Source sentences

    Summary
    The effects of GHRP-6 (10(-6) M) on GH release were shown at 1, 2, 3 and 4-h incubation (p 0.05).
    1 context sentence
    Summary · context
    In the present study, the in vitro effects of GHRP-6 on bovine somatotropes separated by elutriation were analyzed as well as its interactions with the GH-releasing hormone (GHRH).
  5. 05LabIn vitro (cells)Efficacy outcome

    In heifer pituitary cells, GHRP‑6 did not significantly stimulate GH release at the first incubation hour.

    In plain wordsIn lab tests, GHRP‑6 did not significantly increase growth hormone release from heifer pituitary cells at the first hour.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH release
    Study

    bovinen: not reported in source

    heifer pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-6) M · 1 hourAs given in this study (bovine).

    Source sentences

    Summary
    The effects of GHRP-6 (10(-6) M) on GH release were shown at 1, 2, 3 and 4-h incubation (p 0.05).
    1 context sentence
    Summary · context
    In the present study, the in vitro effects of GHRP-6 on bovine somatotropes separated by elutriation were analyzed as well as its interactions with the GH-releasing hormone (GHRH).
  6. 06LabIn vitro (cells)Efficacy outcome

    In bovine pituitary cells, GHRP‑6 alone stimulated less GH release than GHRH alone.

    In plain wordsIn lab tests, GHRP‑6 alone stimulated less growth hormone release than GHRH alone in bovine pituitary cells.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH release
    Study

    bovinen: not reported in source

    elutriated heifer and cow adenohypophysial cells
    Comparator
    GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The GH releasing effects of either GHRH alone or GHRH+GHRP-6 were significantly more potent than that of GHRP-6 alone (p < 0.05).
    1 context sentence
    Summary · context
    In the present study, the in vitro effects of GHRP-6 on bovine somatotropes separated by elutriation were analyzed as well as its interactions with the GH-releasing hormone (GHRH).
  7. 07LabIn vitro (cells)Efficacy outcome

    In bovine pituitary cells, adding GHRP‑6 to GHRH significantly increased GH release versus GHRH alone.

    In plain wordsIn lab tests, adding GHRP‑6 increased growth hormone release more than GHRH alone in bovine pituitary cells.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH release
    Study

    bovinen: not reported in source

    elutriated heifer and cow adenohypophysial cells
    Comparator
    GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-6) MAs given in this study (bovine).

    Source sentences

    Summary
    Although the additive effect was significant when compared with GHRH alone (p < 0.05).
    2 context sentences
    Summary · context
    Contrary to what occurred in rat pituitary cells, the combined administration of 10(-6) M GHRP-6 with 10(-8) M GHRH did not result in a synergist action of GH release.
    Summary · context
    In the present study, the in vitro effects of GHRP-6 on bovine somatotropes separated by elutriation were analyzed as well as its interactions with the GH-releasing hormone (GHRH).

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 08LabNot a test of GHRP-6 aloneIn vitro (cells)Efficacy outcome

    In bovine pituitary cells, GHRH plus GHRP‑6 stimulated more GH release than GHRP‑6 alone.

    In plain wordsIn lab tests, GHRH plus GHRP‑6 stimulated more growth hormone release than GHRP‑6 alone in bovine pituitary cells.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH release
    Study

    bovinen: not reported in source

    elutriated heifer and cow adenohypophysial cells
    Comparator
    GHRP-6 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The GH releasing effects of either GHRH alone or GHRH+GHRP-6 were significantly more potent than that of GHRP-6 alone (p < 0.05).
    1 context sentence
    Summary · context
    In the present study, the in vitro effects of GHRP-6 on bovine somatotropes separated by elutriation were analyzed as well as its interactions with the GH-releasing hormone (GHRH).

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 09LabNot a test of GHRP-6 aloneIn vitro (cells)Efficacy outcome

    In bovine pituitary cells, GHRP‑6 plus GHRH did not show synergistic GH release.

    In plain wordsIn lab tests, GHRP‑6 plus GHRH did not show synergistic growth hormone release from bovine pituitary cells.

    Peptide
    GHRP-6
    Outcome
    No significant changeSynergy of GH release
    Study

    bovinen: not reported in source

    elutriated heifer and cow adenohypophysial cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Contrary to what occurred in rat pituitary cells, the combined administration of 10(-6) M GHRP-6 with 10(-8) M GHRH did not result in a synergist action of GH release.
    1 context sentence
    Summary · context
    In the present study, the in vitro effects of GHRP-6 on bovine somatotropes separated by elutriation were analyzed as well as its interactions with the GH-releasing hormone (GHRH).

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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