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Study · Animal study (in vivo) · rat · 1999

2 results

Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.

Adan RA, Szklarczyk AW, Oosterom J, Brakkee JH, Nijenhuis WA, Schaaper WM, Meloen RH, Gispen WH

European journal of pharmacology1 Aug 1999Cited by 80 (Europe PMC)

PMID10493100 (opens in a new tab)DOI10.1016/s0014-2999(99)00465-3 (opens in a new tab)PepBankPUB-10493100
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intravenous Melanotan II induced grooming behavior.

    In plain wordsIn rats, Melanotan II given into a vein caused grooming behavior.

    Peptide
    Melanotan II
    Outcome
    IncreaseGrooming behavior after intravenous Melanotan-II
    Study

    ratn: not reported in source

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Melanotan-II, [Nle4-D-Phe7]alpha-MSH and RMI-2001 were also effective in inducing grooming behavior when administered intravenously.
    1 context sentence
    Summary · context
    Since the melanocortin MC3 and melanocortin MC4 receptors are the main melanocortin receptor subtypes expressed in rat brain, we characterized the activity and affinity of nine melanocortin receptor ligands using these receptors in vitro, as well as their activity in a well-defined melanocortin-indu…

Studies that did not test the peptide alone1

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 02LabNot a test of Melanotan II aloneIn vitro (cells)Activity measurement

    The analog [D-Tyr4]melanotan II had significantly higher affinity and potency at the rat MC4 receptor than at the rat MC3 receptor.

    In plain wordsIn cells, an altered Melanotan II analog bound and activated one rat melanocortin receptor more strongly than another.

    Peptide
    Melanotan II
    Outcome
    Not applicableSelectivity of [D-Tyr4]melanotan-II for rat MC4 over MC3 receptor
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    We report here that [D-Tyr4]melanotan-II and RMI-2001 (Ac-cyclo-[Cys4, Gly5, D-Phe7, Cys10]alpha-MSH-NH2) have significantly higher affinity and potency on the rat melanocortin MC4 receptor as compared to the rat melanocortin MC3 receptor.
    1 context sentence
    Summary · context
    Since the melanocortin MC3 and melanocortin MC4 receptors are the main melanocortin receptor subtypes expressed in rat brain, we characterized the activity and affinity of nine melanocortin receptor ligands using these receptors in vitro, as well as their activity in a well-defined melanocortin-indu…

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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