Intermittent administration of human parathyroid Hormone(1-34) prevents immobilization-related bone loss by regulating bone marrow capacity for bone cells in ddY mice.

Sakai A, Sakata T, Ikeda S, Uchida S, Okazaki R, Norimura T, Hori M, Nakamura T

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 Oct 1999Cited by 36 (Europe PMC)

PMID10491216DOI10.1359/jbmr.1999.14.10.1691PepBankPUB-10491216

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In neurectomized mice, high-dose PTH preserved trabecular bone volume at the contralateral sham level.
In plain wordsIn mice, high-dose PTH preserved bone volume after neurectomy compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTrabecular bone volume
Study
mousen: not reported in source
ddY mice with hindlimb neurectomy and contralateral sham surgery
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg · subcutaneous five times a week · 2, 4, or 6 weeksAs given in this study (mouse).
Source sentences
Summary
Histomorphometric analyses of the trabecular bone of the proximal tibiae revealed that high-dose hPTH injections preserved the trabecular bone volume of the Nx limbs, which was reduced after neurectomy, at the same level as that of the contralateral Sham limbs.
2 context sentences(design, population, supporting numbers)
Summary · context
ddY mice, 6 weeks of age, were neurectomized (Nx) in the right hindlimbs and sham-operated (Sham) in the left limbs for evaluation of the effects of intermittent injections of human parathyroid hormone (hPTH) on trabecular bone turnover and bone marrow cell development in unloaded and loaded limbs.
Summary · context
Mice were given subcutaneous injections of hPTH(1-34) five times a week at a dose of 0 (vehicle), 4 (low dose), or 40 (high dose) microg/kg of body weight for 2, 4, or 6 weeks.
Report a problemFND-1049121601
02AnimalAnimal study (in vivo)Efficacy outcome
In neurectomized mice, high-dose PTH increased mineral apposition rate above the sham limb level.
In plain wordsIn mice, high-dose PTH increased mineral apposition in neurectomized limbs above sham limb values.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseMineral apposition rate
Study
mousen: not reported in source
ddY mice with hindlimb neurectomy and contralateral sham surgery
Comparator
Contralateral sham limbs
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg · subcutaneous five times a week · 2, 4, or 6 weeksAs given in this study (mouse).
Source sentences
Summary
The mineral apposition rate in the Nx limbs was elevated to values above even that of the Sham limbs by high-dose hPTH injections.
2 context sentences(design, population, supporting numbers)
Summary · context
ddY mice, 6 weeks of age, were neurectomized (Nx) in the right hindlimbs and sham-operated (Sham) in the left limbs for evaluation of the effects of intermittent injections of human parathyroid hormone (hPTH) on trabecular bone turnover and bone marrow cell development in unloaded and loaded limbs.
Summary · context
Mice were given subcutaneous injections of hPTH(1-34) five times a week at a dose of 0 (vehicle), 4 (low dose), or 40 (high dose) microg/kg of body weight for 2, 4, or 6 weeks.
Report a problemFND-1049121602
03AnimalAnimal study (in vivo)Efficacy outcome
In neurectomized mice, low-dose PTH maintained bone formation rate at the sham level.
In plain wordsIn mice, low-dose PTH preserved bone formation after neurectomy compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone formation rate
Study
mousen: not reported in source
ddY mice with hindlimb neurectomy and contralateral sham surgery
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
4 microg/kg · subcutaneous five times a week · 2, 4, or 6 weeksAs given in this study (mouse).
Source sentences
Summary
The bone formation rate reduced by neurectomy was maintained at the Sham level by low- and high-dose hPTH injections.
2 context sentences(design, population, supporting numbers)
Summary · context
ddY mice, 6 weeks of age, were neurectomized (Nx) in the right hindlimbs and sham-operated (Sham) in the left limbs for evaluation of the effects of intermittent injections of human parathyroid hormone (hPTH) on trabecular bone turnover and bone marrow cell development in unloaded and loaded limbs.
Summary · context
Mice were given subcutaneous injections of hPTH(1-34) five times a week at a dose of 0 (vehicle), 4 (low dose), or 40 (high dose) microg/kg of body weight for 2, 4, or 6 weeks.
Report a problemFND-1049121603
04AnimalAnimal study (in vivo)Efficacy outcome
In neurectomized mice, high-dose PTH maintained bone formation rate at the sham level.
In plain wordsIn mice, high-dose PTH preserved bone formation after neurectomy compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone formation rate
Study
mousen: not reported in source
ddY mice with hindlimb neurectomy and contralateral sham surgery
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg · subcutaneous five times a week · 2, 4, or 6 weeksAs given in this study (mouse).
Source sentences
Summary
The bone formation rate reduced by neurectomy was maintained at the Sham level by low- and high-dose hPTH injections.
2 context sentences(design, population, supporting numbers)
Summary · context
ddY mice, 6 weeks of age, were neurectomized (Nx) in the right hindlimbs and sham-operated (Sham) in the left limbs for evaluation of the effects of intermittent injections of human parathyroid hormone (hPTH) on trabecular bone turnover and bone marrow cell development in unloaded and loaded limbs.
Summary · context
Mice were given subcutaneous injections of hPTH(1-34) five times a week at a dose of 0 (vehicle), 4 (low dose), or 40 (high dose) microg/kg of body weight for 2, 4, or 6 weeks.
Report a problemFND-1049121604
05AnimalAnimal study (in vivo)Efficacy outcome
In neurectomized mice, high-dose PTH suppressed the neurectomy-induced increase in osteoclast number.
In plain wordsIn mice, high-dose PTH reduced the osteoclast increase after neurectomy compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseOsteoclast number
Study
mousen: not reported in source
ddY mice with hindlimb neurectomy and contralateral sham surgery
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg · subcutaneous five times a week · 2, 4, or 6 weeksAs given in this study (mouse).
Source sentences
Summary
The neurectomy-induced increase in osteoclast number was suppressed by high-dose hPTH injections.
2 context sentences(design, population, supporting numbers)
Summary · context
ddY mice, 6 weeks of age, were neurectomized (Nx) in the right hindlimbs and sham-operated (Sham) in the left limbs for evaluation of the effects of intermittent injections of human parathyroid hormone (hPTH) on trabecular bone turnover and bone marrow cell development in unloaded and loaded limbs.
Summary · context
Mice were given subcutaneous injections of hPTH(1-34) five times a week at a dose of 0 (vehicle), 4 (low dose), or 40 (high dose) microg/kg of body weight for 2, 4, or 6 weeks.
Report a problemFND-1049121605
06AnimalAnimal study (in vivo)Efficacy outcome
In mice, PTH decreased nonadherent marrow cell numbers in neurectomized and sham limbs, with weaker effects after neurectomy.
In plain wordsIn mice, PTH reduced nonadherent marrow cells compared with vehicle, with smaller effects in neurectomized limbs.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseNonadherent marrow cell count
Study
mousen: not reported in source
ddY mice with hindlimb neurectomy and contralateral sham surgery
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous five times a week · 2, 4, or 6 weeksAs given in this study (mouse).
Source sentences
Summary
The hPTH injections decreased the numbers of nonadherent cells and increased those of adherent cells in both the Nx and the Sham limbs, but the effects were less marked in the Nx than in the Sham limbs even at high-dose injections.
2 context sentences(design, population, supporting numbers)
Summary · context
ddY mice, 6 weeks of age, were neurectomized (Nx) in the right hindlimbs and sham-operated (Sham) in the left limbs for evaluation of the effects of intermittent injections of human parathyroid hormone (hPTH) on trabecular bone turnover and bone marrow cell development in unloaded and loaded limbs.
Summary · context
Mice were given subcutaneous injections of hPTH(1-34) five times a week at a dose of 0 (vehicle), 4 (low dose), or 40 (high dose) microg/kg of body weight for 2, 4, or 6 weeks.
Report a problemFND-1049121606
07AnimalAnimal study (in vivo)Efficacy outcome
In mice, PTH increased adherent marrow cell numbers in neurectomized and sham limbs, with weaker effects after neurectomy.
In plain wordsIn mice, PTH increased adherent marrow cells compared with vehicle, with smaller effects in neurectomized limbs.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseAdherent marrow cell count
Study
mousen: not reported in source
ddY mice with hindlimb neurectomy and contralateral sham surgery
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous five times a week · 2, 4, or 6 weeksAs given in this study (mouse).
Source sentences
Summary
The hPTH injections decreased the numbers of nonadherent cells and increased those of adherent cells in both the Nx and the Sham limbs, but the effects were less marked in the Nx than in the Sham limbs even at high-dose injections.
2 context sentences(design, population, supporting numbers)
Summary · context
ddY mice, 6 weeks of age, were neurectomized (Nx) in the right hindlimbs and sham-operated (Sham) in the left limbs for evaluation of the effects of intermittent injections of human parathyroid hormone (hPTH) on trabecular bone turnover and bone marrow cell development in unloaded and loaded limbs.
Summary · context
Mice were given subcutaneous injections of hPTH(1-34) five times a week at a dose of 0 (vehicle), 4 (low dose), or 40 (high dose) microg/kg of body weight for 2, 4, or 6 weeks.
Report a problemFND-1049121607
08AnimalAnimal study (in vivo)Efficacy outcome
In neurectomized mice, high-dose PTH maintained marrow culture osteogenic nodule formation at the sham level.
In plain wordsIn mice, high-dose PTH preserved subsequent marrow culture bone nodule formation compared with vehicle after neurectomy.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOsteogenic nodule formation
Study
mousen: not reported in source
ddY mice with hindlimb neurectomy and contralateral sham surgery
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg · subcutaneous five times a week · 2, 4, or 6 weeksAs given in this study (mouse).
Source sentences
Summary
The formation of osteogenic nodules in the marrow cultures obtained from the Nx limbs was decreased after surgery and was maintained at the level of the Sham limbs by high-dose hPTH injections.
2 context sentences(design, population, supporting numbers)
Summary · context
ddY mice, 6 weeks of age, were neurectomized (Nx) in the right hindlimbs and sham-operated (Sham) in the left limbs for evaluation of the effects of intermittent injections of human parathyroid hormone (hPTH) on trabecular bone turnover and bone marrow cell development in unloaded and loaded limbs.
Summary · context
Mice were given subcutaneous injections of hPTH(1-34) five times a week at a dose of 0 (vehicle), 4 (low dose), or 40 (high dose) microg/kg of body weight for 2, 4, or 6 weeks.
Report a problemFND-1049121608
09AnimalAnimal study (in vivo)Efficacy outcome
In sham limbs of mice, high-dose PTH reduced osteoclast-like multinucleated cell numbers.
In plain wordsIn mice, high-dose PTH reduced osteoclast-like cell numbers in sham limbs compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseOsteoclast-like multinucleated cells in sham limbs
Study
mousen: not reported in source
ddY mice with hindlimb neurectomy and contralateral sham surgery
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg · subcutaneous five times a week · 2, 4, or 6 weeksAs given in this study (mouse).
Source sentences
Summary
The number of osteoclast-like multinucleated cells was reduced in the Sham limbs by high-dose hPTH injections.
2 context sentences(design, population, supporting numbers)
Summary · context
ddY mice, 6 weeks of age, were neurectomized (Nx) in the right hindlimbs and sham-operated (Sham) in the left limbs for evaluation of the effects of intermittent injections of human parathyroid hormone (hPTH) on trabecular bone turnover and bone marrow cell development in unloaded and loaded limbs.
Summary · context
Mice were given subcutaneous injections of hPTH(1-34) five times a week at a dose of 0 (vehicle), 4 (low dose), or 40 (high dose) microg/kg of body weight for 2, 4, or 6 weeks.
Report a problemFND-1049121609
10AnimalAnimal study (in vivo)Efficacy outcome
In neurectomized mice, high-dose PTH maintained osteoclast-like multinucleated cell numbers at the sham level.
In plain wordsIn mice, high-dose PTH prevented increased osteoclast-like cell numbers after neurectomy compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseOsteoclast-like multinucleated cells after neurectomy
Study
mousen: not reported in source
ddY mice with hindlimb neurectomy and contralateral sham surgery
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg · subcutaneous five times a week · 2, 4, or 6 weeksAs given in this study (mouse).
Source sentences
Summary
The value was increased at 2 weeks after neurectomy, but it was maintained at the Sham level by high-dose hPTH injections through the experimental period.
3 context sentences(design, population, supporting numbers)
Summary · context
The number of osteoclast-like multinucleated cells was reduced in the Sham limbs by high-dose hPTH injections.
Summary · context
ddY mice, 6 weeks of age, were neurectomized (Nx) in the right hindlimbs and sham-operated (Sham) in the left limbs for evaluation of the effects of intermittent injections of human parathyroid hormone (hPTH) on trabecular bone turnover and bone marrow cell development in unloaded and loaded limbs.
Summary · context
Mice were given subcutaneous injections of hPTH(1-34) five times a week at a dose of 0 (vehicle), 4 (low dose), or 40 (high dose) microg/kg of body weight for 2, 4, or 6 weeks.
Report a problemFND-1049121610
11AnimalAnimal study (in vivo)Efficacy outcome
In mice, PTH did not alter fibroblastic colony forming unit numbers.
In plain wordsIn mice, PTH did not change fibroblastic colony numbers compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeFibroblastic colony forming units
Study
mousen: not reported in source
ddY mice with hindlimb neurectomy and contralateral sham surgery
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous five times a week · 2, 4, or 6 weeksAs given in this study (mouse).
Source sentences
Summary
The numbers of colony forming units-fibroblastic, which were reduced by neurectomy, and those of colony forming units for granulocytes and macrophages were not altered by hPTH injections.
2 context sentences(design, population, supporting numbers)
Summary · context
ddY mice, 6 weeks of age, were neurectomized (Nx) in the right hindlimbs and sham-operated (Sham) in the left limbs for evaluation of the effects of intermittent injections of human parathyroid hormone (hPTH) on trabecular bone turnover and bone marrow cell development in unloaded and loaded limbs.
Summary · context
Mice were given subcutaneous injections of hPTH(1-34) five times a week at a dose of 0 (vehicle), 4 (low dose), or 40 (high dose) microg/kg of body weight for 2, 4, or 6 weeks.
Report a problemFND-1049121611
12AnimalAnimal study (in vivo)Efficacy outcome
In mice, PTH did not alter granulocyte and macrophage colony forming unit numbers.
In plain wordsIn mice, PTH did not change granulocyte and macrophage colony numbers compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeGranulocyte and macrophage colony forming units
Study
mousen: not reported in source
ddY mice with hindlimb neurectomy and contralateral sham surgery
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous five times a week · 2, 4, or 6 weeksAs given in this study (mouse).
Source sentences
Summary
The numbers of colony forming units-fibroblastic, which were reduced by neurectomy, and those of colony forming units for granulocytes and macrophages were not altered by hPTH injections.
2 context sentences(design, population, supporting numbers)
Summary · context
ddY mice, 6 weeks of age, were neurectomized (Nx) in the right hindlimbs and sham-operated (Sham) in the left limbs for evaluation of the effects of intermittent injections of human parathyroid hormone (hPTH) on trabecular bone turnover and bone marrow cell development in unloaded and loaded limbs.
Summary · context
Mice were given subcutaneous injections of hPTH(1-34) five times a week at a dose of 0 (vehicle), 4 (low dose), or 40 (high dose) microg/kg of body weight for 2, 4, or 6 weeks.
Report a problemFND-1049121612

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Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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