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Study · Animal study (in vivo) · sheep · 1999

5 results

The modulation of gonadotrophic hormone action on the ovary by paracrine and autocrine factors.

Campbell BK

Anatomia, histologia, embryologia1 Aug 1999Cited by 12 (Europe PMC)

PMID10488630 (opens in a new tab)DOI10.1046/j.1439-0264.1999.00200.x (opens in a new tab)PepBankPUB-10488630
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sheep with an ovarian autotransplant, IGF-I (LR3 analogue) stimulated ovarian follicle development.

    In plain wordsIn sheep, an IGF-I analogue stimulated ovarian follicle development.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseOvarian follicle development in vivo
    Study

    sheepn: not reported in source

    Ovarian autotransplant with intra-arterial infusion
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intra-arterial infusionAs given in this study (sheep).

    Source sentences

    Summary
    IGF-I stimulated both cellular proliferation and hormone production by both granulosa and theca cells in vitro and similarly stimulated ovarian follicle development and ovarian androgen and oestradiol secretion in vivo.
    1 context sentence
    Summary · context
    Experiments in vivo utilized sheep with an ovarian autotransplant to allow intra-arterial infusion of putative local factors and exposure of the ovary to high local concentrations.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In sheep with an ovarian autotransplant, IGF-I (LR3 analogue) stimulated ovarian androgen secretion.

    In plain wordsIn sheep, an IGF-I analogue stimulated ovarian androgen secretion.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseOvarian androgen secretion in vivo
    Study

    sheepn: not reported in source

    Ovarian autotransplant with intra-arterial infusion
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intra-arterial infusionAs given in this study (sheep).

    Source sentences

    Summary
    IGF-I stimulated both cellular proliferation and hormone production by both granulosa and theca cells in vitro and similarly stimulated ovarian follicle development and ovarian androgen and oestradiol secretion in vivo.
    1 context sentence
    Summary · context
    Experiments in vivo utilized sheep with an ovarian autotransplant to allow intra-arterial infusion of putative local factors and exposure of the ovary to high local concentrations.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In sheep with an ovarian autotransplant, IGF-I (LR3 analogue) stimulated ovarian oestradiol secretion.

    In plain wordsIn sheep, an IGF-I analogue stimulated ovarian oestradiol secretion.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseOvarian oestradiol secretion in vivo
    Study

    sheepn: not reported in source

    Ovarian autotransplant with intra-arterial infusion
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intra-arterial infusionAs given in this study (sheep).

    Source sentences

    Summary
    IGF-I stimulated both cellular proliferation and hormone production by both granulosa and theca cells in vitro and similarly stimulated ovarian follicle development and ovarian androgen and oestradiol secretion in vivo.
    1 context sentence
    Summary · context
    Experiments in vivo utilized sheep with an ovarian autotransplant to allow intra-arterial infusion of putative local factors and exposure of the ovary to high local concentrations.
  4. 04LabIn vitro (cells)Efficacy outcome

    In serum-free granulosa and theca cell cultures, IGF-I (LR3 analogue) stimulated cellular proliferation.

    In plain wordsIn lab tests on ovarian cells, an IGF-I analogue stimulated cell growth.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseGranulosa and theca cell proliferation in vitro
    Study

    n: not reported in source

    Serum-free granulosa and theca cell cultures
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-I stimulated both cellular proliferation and hormone production by both granulosa and theca cells in vitro and similarly stimulated ovarian follicle development and ovarian androgen and oestradiol secretion in vivo.
    1 context sentence
    Summary · context
    Experiments in vitro utilized physiological serum-free cell culture systems for both granulosa and theca cells that allow gonadotrophin-induced differentiation in vitro.
  5. 05LabIn vitro (cells)Efficacy outcome

    In serum-free granulosa and theca cell cultures, IGF-I (LR3 analogue) stimulated hormone production.

    In plain wordsIn lab tests on ovarian cells, an IGF-I analogue stimulated hormone production.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseHormone production by granulosa and theca cells in vitro
    Study

    n: not reported in source

    Serum-free granulosa and theca cell cultures
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-I stimulated both cellular proliferation and hormone production by both granulosa and theca cells in vitro and similarly stimulated ovarian follicle development and ovarian androgen and oestradiol secretion in vivo.
    1 context sentence
    Summary · context
    Experiments in vitro utilized physiological serum-free cell culture systems for both granulosa and theca cells that allow gonadotrophin-induced differentiation in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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