In rats with dopamine-system hyperactivity induced by L-DOPA or amphetamine, a single DSIP injection corrected the neurochemical changes, with effects that depended on the drug used and on the brain structure.
In plain wordsIn rats with overactive dopamine systems, DSIP corrected some brain chemical changes, and the effect differed by drug and brain area.
- Outcome
- MixedBrain serotonergic and dopaminergic parameters under dopamine-system hyperactivity
- Study
ratn: not reported in source
rats with dopaminergic hyperactivity induced by L-DOPA or amphetamine- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- 30 microg/kg body weightAs given in this study (rat).
Source sentences
Changes caused by the two DA-system activating drugs had both similarities and differences, and the corrective action of DSIP also had certain peculiarities depending on the pharmacological preparation used for the induction of DA-system hyperactivity and on the investigated brain structure.
2 context sentences(design, population, supporting numbers)
The influence of a single injection of "delta-sleep-inducing peptide" (DSIP; 30 microg/kg body weight) on neurochemical parameters of rats' brain was studied under the conditions of chronic administration of dopamine analogs inducing DA-system hyperactivity - 50 mg/kg body weight of L-DOPA for 30 da…
The parameters of serotonergic system (MAO A activity, 5-HT, and 5-HIAA contents) and of dopaminergic system (MAO B activity, DA, NA, and HVA contents) were investigated in the cortex and caudate nucleus of control, DA or amphetamine, and DSIP receiving rats.