Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 24-month-old rats.

Reinprecht I, Gschanes A, Windisch M, Fachbach G

The Histochemical journal1 Jun 1999Cited by 33 (Europe PMC)

PMID10462225DOI10.1023/a:1003752208971PepBankPUB-10462225

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin increased synaptophysin-immunostained presynaptic terminals in the entorhinal cortex compared with saline.
In plain wordsIn rats, Cerebrolysin increased marked presynaptic nerve terminals in the entorhinal cortex compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseEntorhinal cortex presynaptic terminals
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline controls
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5 ml/kg per day · 19 consecutive daysAs given in this study (rat).
Source sentences
Summary
Our results clearly showed that the rats benefit from the administration of both drugs, showing an enhancement in the number of synaptophysin-immunostained presynaptic terminals in the entorhinal cortex, the dentate gyrus, and also in the hippocampal subfields CA1, CA2, CA3 stratum lucidum and CA3 stratum radiatum.
4 context sentences(design, population, supporting numbers)
Summary · context
In the present study, the effects of Cerebrolysin and its peptide preparation E021 on the synapse density in the hippocampus, the dentate gyrus and in the entorhinal cortex of 24-month-old rats were investigated.
Summary · context
Rats received the drugs or saline for control for 19 consecutive days (2.5 ml/kg per day).
Summary · context
Slices of the brains were immunohistochemically stained with anti-synaptophysin, which is a specific marker of presynaptic terminals.
Summary · context
Quantification of the synapse density was done by using light microscopy and a computerised image analysing system.
Report a problemFND-1046222501
02AnimalAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin increased synaptophysin-immunostained presynaptic terminals in the dentate gyrus compared with saline.
In plain wordsIn rats, Cerebrolysin increased marked presynaptic nerve terminals in the dentate gyrus compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseDentate gyrus presynaptic terminals
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline controls
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5 ml/kg per day · 19 consecutive daysAs given in this study (rat).
Source sentences
Summary
Our results clearly showed that the rats benefit from the administration of both drugs, showing an enhancement in the number of synaptophysin-immunostained presynaptic terminals in the entorhinal cortex, the dentate gyrus, and also in the hippocampal subfields CA1, CA2, CA3 stratum lucidum and CA3 stratum radiatum.
4 context sentences(design, population, supporting numbers)
Summary · context
In the present study, the effects of Cerebrolysin and its peptide preparation E021 on the synapse density in the hippocampus, the dentate gyrus and in the entorhinal cortex of 24-month-old rats were investigated.
Summary · context
Rats received the drugs or saline for control for 19 consecutive days (2.5 ml/kg per day).
Summary · context
Slices of the brains were immunohistochemically stained with anti-synaptophysin, which is a specific marker of presynaptic terminals.
Summary · context
Quantification of the synapse density was done by using light microscopy and a computerised image analysing system.
Report a problemFND-1046222502
03AnimalAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin increased synaptophysin-immunostained presynaptic terminals in hippocampal CA1 compared with saline.
In plain wordsIn rats, Cerebrolysin increased marked presynaptic nerve terminals in hippocampal CA1 compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseCA1 presynaptic terminals
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline controls
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5 ml/kg per day · 19 consecutive daysAs given in this study (rat).
Source sentences
Summary
Our results clearly showed that the rats benefit from the administration of both drugs, showing an enhancement in the number of synaptophysin-immunostained presynaptic terminals in the entorhinal cortex, the dentate gyrus, and also in the hippocampal subfields CA1, CA2, CA3 stratum lucidum and CA3 stratum radiatum.
4 context sentences(design, population, supporting numbers)
Summary · context
In the present study, the effects of Cerebrolysin and its peptide preparation E021 on the synapse density in the hippocampus, the dentate gyrus and in the entorhinal cortex of 24-month-old rats were investigated.
Summary · context
Rats received the drugs or saline for control for 19 consecutive days (2.5 ml/kg per day).
Summary · context
Slices of the brains were immunohistochemically stained with anti-synaptophysin, which is a specific marker of presynaptic terminals.
Summary · context
Quantification of the synapse density was done by using light microscopy and a computerised image analysing system.
Report a problemFND-1046222503
04AnimalAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin increased synaptophysin-immunostained presynaptic terminals in hippocampal CA2 compared with saline.
In plain wordsIn rats, Cerebrolysin increased marked presynaptic nerve terminals in hippocampal CA2 compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseCA2 presynaptic terminals
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline controls
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5 ml/kg per day · 19 consecutive daysAs given in this study (rat).
Source sentences
Summary
Our results clearly showed that the rats benefit from the administration of both drugs, showing an enhancement in the number of synaptophysin-immunostained presynaptic terminals in the entorhinal cortex, the dentate gyrus, and also in the hippocampal subfields CA1, CA2, CA3 stratum lucidum and CA3 stratum radiatum.
4 context sentences(design, population, supporting numbers)
Summary · context
In the present study, the effects of Cerebrolysin and its peptide preparation E021 on the synapse density in the hippocampus, the dentate gyrus and in the entorhinal cortex of 24-month-old rats were investigated.
Summary · context
Rats received the drugs or saline for control for 19 consecutive days (2.5 ml/kg per day).
Summary · context
Slices of the brains were immunohistochemically stained with anti-synaptophysin, which is a specific marker of presynaptic terminals.
Summary · context
Quantification of the synapse density was done by using light microscopy and a computerised image analysing system.
Report a problemFND-1046222504
05AnimalAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin increased synaptophysin-immunostained presynaptic terminals in CA3 stratum lucidum compared with saline.
In plain wordsIn rats, Cerebrolysin increased marked presynaptic nerve terminals in CA3 stratum lucidum compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseCA3 stratum lucidum presynaptic terminals
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline controls
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5 ml/kg per day · 19 consecutive daysAs given in this study (rat).
Source sentences
Summary
Our results clearly showed that the rats benefit from the administration of both drugs, showing an enhancement in the number of synaptophysin-immunostained presynaptic terminals in the entorhinal cortex, the dentate gyrus, and also in the hippocampal subfields CA1, CA2, CA3 stratum lucidum and CA3 stratum radiatum.
4 context sentences(design, population, supporting numbers)
Summary · context
In the present study, the effects of Cerebrolysin and its peptide preparation E021 on the synapse density in the hippocampus, the dentate gyrus and in the entorhinal cortex of 24-month-old rats were investigated.
Summary · context
Rats received the drugs or saline for control for 19 consecutive days (2.5 ml/kg per day).
Summary · context
Slices of the brains were immunohistochemically stained with anti-synaptophysin, which is a specific marker of presynaptic terminals.
Summary · context
Quantification of the synapse density was done by using light microscopy and a computerised image analysing system.
Report a problemFND-1046222505
06AnimalAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin increased synaptophysin-immunostained presynaptic terminals in CA3 stratum radiatum compared with saline.
In plain wordsIn rats, Cerebrolysin increased marked presynaptic nerve terminals in CA3 stratum radiatum compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseCA3 stratum radiatum presynaptic terminals
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline controls
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5 ml/kg per day · 19 consecutive daysAs given in this study (rat).
Source sentences
Summary
Our results clearly showed that the rats benefit from the administration of both drugs, showing an enhancement in the number of synaptophysin-immunostained presynaptic terminals in the entorhinal cortex, the dentate gyrus, and also in the hippocampal subfields CA1, CA2, CA3 stratum lucidum and CA3 stratum radiatum.
4 context sentences(design, population, supporting numbers)
Summary · context
In the present study, the effects of Cerebrolysin and its peptide preparation E021 on the synapse density in the hippocampus, the dentate gyrus and in the entorhinal cortex of 24-month-old rats were investigated.
Summary · context
Rats received the drugs or saline for control for 19 consecutive days (2.5 ml/kg per day).
Summary · context
Slices of the brains were immunohistochemically stained with anti-synaptophysin, which is a specific marker of presynaptic terminals.
Summary · context
Quantification of the synapse density was done by using light microscopy and a computerised image analysing system.
Report a problemFND-1046222506

Studies that did not test the peptide alone6

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

07AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin-derived E021 increased synaptophysin-immunostained presynaptic terminals in the entorhinal cortex compared with saline.
In plain wordsIn rats, the Cerebrolysin preparation E021 increased marked presynaptic nerve terminals in the entorhinal cortex compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseE021 entorhinal cortex presynaptic terminals
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline controls
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Our results clearly showed that the rats benefit from the administration of both drugs, showing an enhancement in the number of synaptophysin-immunostained presynaptic terminals in the entorhinal cortex, the dentate gyrus, and also in the hippocampal subfields CA1, CA2, CA3 stratum lucidum and CA3 stratum radiatum.
4 context sentences(design, population, supporting numbers)
Summary · context
In the present study, the effects of Cerebrolysin and its peptide preparation E021 on the synapse density in the hippocampus, the dentate gyrus and in the entorhinal cortex of 24-month-old rats were investigated.
Summary · context
Rats received the drugs or saline for control for 19 consecutive days (2.5 ml/kg per day).
Summary · context
Slices of the brains were immunohistochemically stained with anti-synaptophysin, which is a specific marker of presynaptic terminals.
Summary · context
Quantification of the synapse density was done by using light microscopy and a computerised image analysing system.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1046222507
08AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin-derived E021 increased synaptophysin-immunostained presynaptic terminals in the dentate gyrus compared with saline.
In plain wordsIn rats, the Cerebrolysin preparation E021 increased marked presynaptic nerve terminals in the dentate gyrus compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseE021 dentate gyrus presynaptic terminals
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline controls
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Our results clearly showed that the rats benefit from the administration of both drugs, showing an enhancement in the number of synaptophysin-immunostained presynaptic terminals in the entorhinal cortex, the dentate gyrus, and also in the hippocampal subfields CA1, CA2, CA3 stratum lucidum and CA3 stratum radiatum.
4 context sentences(design, population, supporting numbers)
Summary · context
In the present study, the effects of Cerebrolysin and its peptide preparation E021 on the synapse density in the hippocampus, the dentate gyrus and in the entorhinal cortex of 24-month-old rats were investigated.
Summary · context
Rats received the drugs or saline for control for 19 consecutive days (2.5 ml/kg per day).
Summary · context
Slices of the brains were immunohistochemically stained with anti-synaptophysin, which is a specific marker of presynaptic terminals.
Summary · context
Quantification of the synapse density was done by using light microscopy and a computerised image analysing system.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1046222508
09AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin-derived E021 increased synaptophysin-immunostained presynaptic terminals in hippocampal CA1 compared with saline.
In plain wordsIn rats, the Cerebrolysin preparation E021 increased marked presynaptic nerve terminals in hippocampal CA1 compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseE021 CA1 presynaptic terminals
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline controls
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Our results clearly showed that the rats benefit from the administration of both drugs, showing an enhancement in the number of synaptophysin-immunostained presynaptic terminals in the entorhinal cortex, the dentate gyrus, and also in the hippocampal subfields CA1, CA2, CA3 stratum lucidum and CA3 stratum radiatum.
4 context sentences(design, population, supporting numbers)
Summary · context
In the present study, the effects of Cerebrolysin and its peptide preparation E021 on the synapse density in the hippocampus, the dentate gyrus and in the entorhinal cortex of 24-month-old rats were investigated.
Summary · context
Rats received the drugs or saline for control for 19 consecutive days (2.5 ml/kg per day).
Summary · context
Slices of the brains were immunohistochemically stained with anti-synaptophysin, which is a specific marker of presynaptic terminals.
Summary · context
Quantification of the synapse density was done by using light microscopy and a computerised image analysing system.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1046222509
10AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin-derived E021 increased synaptophysin-immunostained presynaptic terminals in hippocampal CA2 compared with saline.
In plain wordsIn rats, the Cerebrolysin preparation E021 increased marked presynaptic nerve terminals in hippocampal CA2 compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseE021 CA2 presynaptic terminals
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline controls
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Our results clearly showed that the rats benefit from the administration of both drugs, showing an enhancement in the number of synaptophysin-immunostained presynaptic terminals in the entorhinal cortex, the dentate gyrus, and also in the hippocampal subfields CA1, CA2, CA3 stratum lucidum and CA3 stratum radiatum.
4 context sentences(design, population, supporting numbers)
Summary · context
In the present study, the effects of Cerebrolysin and its peptide preparation E021 on the synapse density in the hippocampus, the dentate gyrus and in the entorhinal cortex of 24-month-old rats were investigated.
Summary · context
Rats received the drugs or saline for control for 19 consecutive days (2.5 ml/kg per day).
Summary · context
Slices of the brains were immunohistochemically stained with anti-synaptophysin, which is a specific marker of presynaptic terminals.
Summary · context
Quantification of the synapse density was done by using light microscopy and a computerised image analysing system.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1046222510
11AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin-derived E021 increased synaptophysin-immunostained presynaptic terminals in CA3 stratum lucidum compared with saline.
In plain wordsIn rats, the Cerebrolysin preparation E021 increased marked presynaptic nerve terminals in CA3 stratum lucidum compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseE021 CA3 stratum lucidum presynaptic terminals
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline controls
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Our results clearly showed that the rats benefit from the administration of both drugs, showing an enhancement in the number of synaptophysin-immunostained presynaptic terminals in the entorhinal cortex, the dentate gyrus, and also in the hippocampal subfields CA1, CA2, CA3 stratum lucidum and CA3 stratum radiatum.
4 context sentences(design, population, supporting numbers)
Summary · context
In the present study, the effects of Cerebrolysin and its peptide preparation E021 on the synapse density in the hippocampus, the dentate gyrus and in the entorhinal cortex of 24-month-old rats were investigated.
Summary · context
Rats received the drugs or saline for control for 19 consecutive days (2.5 ml/kg per day).
Summary · context
Slices of the brains were immunohistochemically stained with anti-synaptophysin, which is a specific marker of presynaptic terminals.
Summary · context
Quantification of the synapse density was done by using light microscopy and a computerised image analysing system.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1046222511
12AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin-derived E021 increased synaptophysin-immunostained presynaptic terminals in CA3 stratum radiatum compared with saline.
In plain wordsIn rats, the Cerebrolysin preparation E021 increased marked presynaptic nerve terminals in CA3 stratum radiatum compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseE021 CA3 stratum radiatum presynaptic terminals
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline controls
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Our results clearly showed that the rats benefit from the administration of both drugs, showing an enhancement in the number of synaptophysin-immunostained presynaptic terminals in the entorhinal cortex, the dentate gyrus, and also in the hippocampal subfields CA1, CA2, CA3 stratum lucidum and CA3 stratum radiatum.
4 context sentences(design, population, supporting numbers)
Summary · context
In the present study, the effects of Cerebrolysin and its peptide preparation E021 on the synapse density in the hippocampus, the dentate gyrus and in the entorhinal cortex of 24-month-old rats were investigated.
Summary · context
Rats received the drugs or saline for control for 19 consecutive days (2.5 ml/kg per day).
Summary · context
Slices of the brains were immunohistochemically stained with anti-synaptophysin, which is a specific marker of presynaptic terminals.
Summary · context
Quantification of the synapse density was done by using light microscopy and a computerised image analysing system.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1046222512

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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