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Study · Animal study (in vivo) · rat · 1999

3 results

Activation of arcuate nucleus neurons by systemic administration of leptin and growth hormone-releasing peptide-6 in normal and fasted rats.

Luckman SM, Rosenzweig I, Dickson SL

Neuroendocrinology1 Aug 1999Cited by 32 (Europe PMC)

PMID10461023 (opens in a new tab)DOI10.1159/000054463 (opens in a new tab)PepBankPUB-10461023
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In male rats, systemic GHRP‑6 induced c-Fos in the ventromedial arcuate nucleus.

    In plain wordsIn male rats, GHRP‑6 induced c-Fos in the ventromedial arcuate nucleus.

    Peptide
    GHRP-6
    Outcome
    IncreaseArcuate c-Fos induction
    Study

    ratn: not reported in source

    normal and fasted male rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · systemicAs given in this study (rat).

    Source sentences

    Summary
    Systemic administration of a normally maximal effective dose of the growth hormone secretagogue GHRP-6 to male rats causes the induction of c-Fos protein in the ventromedial aspect of the hypothalamic arcuate nucleus.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, the same GHRP‑6 dose induced a greater response after fasting than in food-replete animals.

    In plain wordsIn rats, GHRP‑6 induced a greater response after fasting than in fed rats.

    Peptide
    GHRP-6
    Outcome
    IncreaseFasting enhancement of c-Fos response
    Study

    ratn: not reported in source

    normal and fasted male rats
    Comparator
    Food-replete rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · systemicAs given in this study (rat).

    Source sentences

    Summary
    The effect of the same dose of GHRP-6 is, however, much greater in animals that have been fasted for 48 h, suggesting that in the food-replete rat, arcuate neurons either show reduced sensitivity to endogenous growth hormone secretagogues or they are under the tonic inhibitory influences of other factors.

Studies that did not test the peptide alone1

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 03AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In rats, leptin did not alter the response to GHRP‑6.

    In plain wordsIn rats, leptin did not change the response to GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    No significant changeLeptin modulation of GHRP-6 response
    Study

    ratn: not reported in source

    normal and fasted male rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Leptin did not alter the response of the rats to GHRP-6.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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