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Study · In vitro (cells) · rat · 1999

5 results

Effects of Cerebrolysin on in vitro primary microglial and astrocyte rat cell cultures.

Lombardi VR, Windisch M, García M, Cacabelos R

Methods and findings in experimental and clinical pharmacology1 Jun 1999Cited by 17 (Europe PMC)

PMID10420388 (opens in a new tab)DOI10.1358/mf.1999.21.5.541910 (opens in a new tab)PepBankPUB-10420388
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat microglial cultures, Cerebrolysin downregulated activation after LPS treatment.

    In plain wordsIn cells from rats, Cerebrolysin reduced microglial activation after LPS exposure.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseLPS-induced microglial activation
    Study

    ratn: not reported in source

    LPS-treated microglial cultures
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results obtained in this study clearly suggest a protective effect of Cerebrolysin as revealed by downregulation of microglial activation after LPS treatment as well as by the control of IL-1 beta expression.
    1 context sentence
    Summary · context
    To determine whether Cerebrolysin, a porcine brain-derived peptide preparation, was able to modulate in vitro lipopolysaccharide (LPS)-induced microglial activation and to test the direct effect of Cerebrolysin on astrocyte morphology, survival and proliferation, rat glial and astrocyte cell culture…
  2. 02LabIn vitro (cells)Mechanism

    In rat glial cultures, Cerebrolysin controlled IL-1 beta expression, with the direction unspecified in the abstract.

    In plain wordsIn cells from rats, Cerebrolysin controlled IL-1 beta expression. The abstract does not state the direction.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedIL-1 beta expression
    Study

    ratn: not reported in source

    Rat glial cell cultures
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results obtained in this study clearly suggest a protective effect of Cerebrolysin as revealed by downregulation of microglial activation after LPS treatment as well as by the control of IL-1 beta expression.
    1 context sentence
    Summary · context
    To determine whether Cerebrolysin, a porcine brain-derived peptide preparation, was able to modulate in vitro lipopolysaccharide (LPS)-induced microglial activation and to test the direct effect of Cerebrolysin on astrocyte morphology, survival and proliferation, rat glial and astrocyte cell culture…
  3. 03LabIn vitro (cells)Mechanism

    In rat astrocyte cultures, Cerebrolysin showed no significant effect on morphology.

    In plain wordsIn cells from rats, Cerebrolysin did not significantly change astrocyte shape.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeAstrocyte morphology
    Study

    ratn: not reported in source

    Rat astrocyte cultures
    Outcome group
    Neuroprotection · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No significant differences were observed on astrocyte morphology, survival or the production and/or release of BDNF.
    1 context sentence
    Summary · context
    To determine whether Cerebrolysin, a porcine brain-derived peptide preparation, was able to modulate in vitro lipopolysaccharide (LPS)-induced microglial activation and to test the direct effect of Cerebrolysin on astrocyte morphology, survival and proliferation, rat glial and astrocyte cell culture…
  4. 04LabIn vitro (cells)Mechanism

    In rat astrocyte cultures, Cerebrolysin showed no significant effect on survival.

    In plain wordsIn cells from rats, Cerebrolysin did not significantly change astrocyte survival.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeAstrocyte survival
    Study

    ratn: not reported in source

    Rat astrocyte cultures
    Outcome group
    Neuroprotection · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No significant differences were observed on astrocyte morphology, survival or the production and/or release of BDNF.
    1 context sentence
    Summary · context
    To determine whether Cerebrolysin, a porcine brain-derived peptide preparation, was able to modulate in vitro lipopolysaccharide (LPS)-induced microglial activation and to test the direct effect of Cerebrolysin on astrocyte morphology, survival and proliferation, rat glial and astrocyte cell culture…
  5. 05LabIn vitro (cells)Mechanism

    In rat glial and astrocyte cultures, Cerebrolysin showed no significant differences in BDNF production and/or release.

    In plain wordsIn cells from rats, Cerebrolysin did not significantly change BDNF production or release.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeBDNF production and/or release
    Study

    ratn: not reported in source

    Rat glial and astrocyte cultures
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No significant differences were observed on astrocyte morphology, survival or the production and/or release of BDNF.
    1 context sentence
    Summary · context
    To determine whether Cerebrolysin, a porcine brain-derived peptide preparation, was able to modulate in vitro lipopolysaccharide (LPS)-induced microglial activation and to test the direct effect of Cerebrolysin on astrocyte morphology, survival and proliferation, rat glial and astrocyte cell culture…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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