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Study · Animal study (in vivo) · rat · 1999

3 results

Thymulin induces c-fos expression in the spinal cord of rats which is reversed by meloxicam and morphine.

Saadé NE, Lawand HF, Safieh-Garabedian B, Kanaan SA, Atweh SF, Jabbur SJ

Journal of neuroimmunology1 Jun 1999Cited by 8 (Europe PMC)

PMID10408970 (opens in a new tab)DOI10.1016/s0165-5728(99)00031-4 (opens in a new tab)PepBankPUB-10408970
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, thymulin produced significant sustained fos-like immunoreactivity in spinal neurons in nociceptive laminae.

    In plain wordsIn rats, thymulin increased a marker of sustained activity in spinal neurons involved in pain.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseSpinal neuronal fos-like immunoreactivity
    Study

    ratn: not reported in source

    thymulin-induced spinal neuronal activation
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraplantarAs given in this study (rat).

    Source sentences

    Summary
    Our results showed that thymulin produces significant and sustained FLI in neurons located in spinal laminae known to be involved in nociception.
    1 context sentence
    Summary · context
    This study aimed at investigating if such injections can produce sustained activation of spinal neurons by mapping the fos-like-immunoreactivity (FLI) as a marker for this activation.

Studies that did not test the peptide alone2

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 02AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In rats, morphine and meloxicam pretreatments had differential effects on thymulin-induced fos-like immunoreactivity.

    In plain wordsIn rats, morphine and meloxicam had different effects on thymulin-induced spinal activity markers.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedFos-like immunoreactivity after analgesic pretreatment
    Study

    ratn: not reported in source

    thymulin-induced spinal neuronal activation
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Pretreatment with either morphine or meloxicam (a cyclooxygenase inhibitor) revealed differential effects on FLI and the hyperalgesia induced by thymulin.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 03AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In rats, morphine and meloxicam pretreatments had differential effects on thymulin-induced hyperalgesia.

    In plain wordsIn rats, morphine and meloxicam had different effects on thymulin-induced pain sensitivity.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedHyperalgesia after analgesic pretreatment
    Study

    ratn: not reported in source

    thymulin-induced spinal neuronal activation
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    Pretreatment with either morphine or meloxicam (a cyclooxygenase inhibitor) revealed differential effects on FLI and the hyperalgesia induced by thymulin.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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