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Study · Animal study (in vivo) · cattle · 1999

7 results

Action of long(R3)-insulin-like growth factor-1 on protein metabolism in beef heifers.

Hill RA, Hunter RA, Lindsay DB, Owens PC

Domestic animal endocrinology1 May 1999Cited by 7 (Europe PMC)

PMID10370861 (opens in a new tab)DOI10.1016/s0739-7240(99)00015-6 (opens in a new tab)PepBankPUB-10370861
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In underfed beef heifers, Long(R3)-IGF-1 showed only a tendency to conserve whole-body protein.

    In plain wordsIn underfed cattle, an IGF-1 analogue only tended to preserve whole-body protein.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeWhole-body protein
    Study

    cattlen: not reported in source

    Beef heifers on restricted feeding
    Comparator
    Control group
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    Dose not stated · intravenous infusion · 8 hoursAs given in this study (cattle).

    Source sentences

    Summary
    There was a tendency for both whole-body protein and skeletal muscle protein to be conserved in Long(R3)-IGF-1-treated heifers.
    1 context sentence
    Summary · context
    We have determined the effects of an i.v. infusion of the IGF-1 analog Long(R3)-IGF-1 on protein metabolism in beef heifers that were slowly losing liveweight because of restricted feeding.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In underfed beef heifers, Long(R3)-IGF-1 showed only a tendency to conserve skeletal muscle protein.

    In plain wordsIn underfed cattle, an IGF-1 analogue only tended to preserve muscle protein.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeSkeletal muscle protein
    Study

    cattlen: not reported in source

    Beef heifers on restricted feeding
    Comparator
    Control group
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    Dose not stated · intravenous infusion · 8 hoursAs given in this study (cattle).

    Source sentences

    Summary
    There was a tendency for both whole-body protein and skeletal muscle protein to be conserved in Long(R3)-IGF-1-treated heifers.
    1 context sentence
    Summary · context
    We have determined the effects of an i.v. infusion of the IGF-1 analog Long(R3)-IGF-1 on protein metabolism in beef heifers that were slowly losing liveweight because of restricted feeding.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In underfed beef heifers, Long(R3)-IGF-1 markedly reduced the plasma concentrations of all amino acids measured.

    In plain wordsIn underfed cattle, an IGF-1 analogue strongly lowered blood amino acid levels.

    Peptide
    IGF-1 LR3
    Outcome
    DecreasePlasma amino acid concentrations
    Study

    cattlen: not reported in source

    Beef heifers on restricted feeding
    Comparator
    Control group
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    Dose not stated · intravenous infusion · 8 hoursAs given in this study (cattle).

    Source sentences

    Summary
    Long(R3)-IGF-1 administration markedly reduced the plasma concentrations of all amino acids measured and glucose.
    1 context sentence
    Summary · context
    We have determined the effects of an i.v. infusion of the IGF-1 analog Long(R3)-IGF-1 on protein metabolism in beef heifers that were slowly losing liveweight because of restricted feeding.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In underfed beef heifers, Long(R3)-IGF-1 markedly reduced plasma glucose.

    In plain wordsIn underfed cattle, an IGF-1 analogue strongly lowered blood glucose.

    Peptide
    IGF-1 LR3
    Outcome
    DecreasePlasma glucose
    Study

    cattlen: not reported in source

    Beef heifers on restricted feeding
    Comparator
    Control group
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intravenous infusion · 8 hoursAs given in this study (cattle).

    Source sentences

    Summary
    Long(R3)-IGF-1 administration markedly reduced the plasma concentrations of all amino acids measured and glucose.
    1 context sentence
    Summary · context
    We have determined the effects of an i.v. infusion of the IGF-1 analog Long(R3)-IGF-1 on protein metabolism in beef heifers that were slowly losing liveweight because of restricted feeding.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In underfed beef heifers, plasma IGF-1 concentrations decreased sharply during Long(R3)-IGF-1 infusion.

    In plain wordsIn underfed cattle, the animal's own blood IGF-1 fell sharply during infusion of an IGF-1 analogue.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseEndogenous plasma IGF-1
    Study

    cattlen: not reported in source

    Beef heifers on restricted feeding
    Comparator
    Control group
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous infusion · 8 hoursAs given in this study (cattle).

    Source sentences

    Summary
    There was a significant change in the profile differences of endogenous plasma IGF-1 concentrations during the 8-hr infusion period, with plasma IGF-1 decreasing sharply in the test group.
    1 context sentence
    Summary · context
    We have determined the effects of an i.v. infusion of the IGF-1 analog Long(R3)-IGF-1 on protein metabolism in beef heifers that were slowly losing liveweight because of restricted feeding.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In underfed beef heifers, plasma IGF-2 fell by about 140 ng/ml in the Long(R3)-IGF-1 group versus about 40 ng/ml in controls.

    In plain wordsIn underfed cattle, blood IGF-2 fell much more with an IGF-1 analogue than in controls.

    Peptide
    IGF-1 LR3
    Outcome
    DecreasePlasma IGF-2
    Study

    cattlen: not reported in source

    Beef heifers on restricted feeding
    Comparator
    Control group
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous infusion · 8 hoursAs given in this study (cattle).

    Measurements

    Plasma IGF-2 decrease
    140 ng/ml
    test group
    Plasma IGF-2 decrease
    40 ng/ml
    control group

    Source sentences

    Summary
    Overall, plasma IGF-2 for the control group decreased only slightly over time (about 40 ng/ml), whereas the test group decreased dramatically (by about 140 ng/ml).
    1 context sentence
    Summary · context
    We have determined the effects of an i.v. infusion of the IGF-1 analog Long(R3)-IGF-1 on protein metabolism in beef heifers that were slowly losing liveweight because of restricted feeding.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In underfed beef heifers, plasma concentrations of a 31-32-kDa IGF-binding protein increased with Long(R3)-IGF-1 treatment.

    In plain wordsIn underfed cattle, an IGF-1 analogue raised blood levels of an IGF-binding protein.

    Peptide
    IGF-1 LR3
    Outcome
    Increase31-32 kDa IGF-binding protein
    Study

    cattlen: not reported in source

    Beef heifers on restricted feeding
    Comparator
    Control group
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous infusion · 8 hoursAs given in this study (cattle).

    Source sentences

    Summary
    Increased plasma concentrations of a 31-32-kDa IGF-binding protein (possibly IGF-binding protein-1) in the treated group was detected by radioligand blot.
    1 context sentence
    Summary · context
    We have determined the effects of an i.v. infusion of the IGF-1 analog Long(R3)-IGF-1 on protein metabolism in beef heifers that were slowly losing liveweight because of restricted feeding.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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