Efficacy and safety of recombinant human follicle stimulating hormone (Gonal-F) with urinary human chorionic gonadotrophin for induction of spermatogenesis and fertility in gonadotrophin-deficient men.

Liu PY, Turner L, Rushford D, McDonald J, Baker HW, Conway AJ, Handelsman DJ

Human reproduction (Oxford, England)1 Jun 1999Cited by 62 (Europe PMC)

PMID10357972DOI10.1093/humrep/14.6.1540PepBankPUB-10357972

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking hCG (human chorionic gonadotropin).

01HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
In gonadotrophin-deficient men receiving r-hFSH with HCG, seven of eight demonstrated sperm output at a median of 6 months.
In plain wordsIn gonadotrophin-deficient men receiving r-hFSH with HCG, seven of eight produced sperm at a median of 6 months.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSperm output
Study
n = 8
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Men with sperm output
7 men (of 8 who started r-hFSH)
r-hFSH with HCG
Median time to sperm output
6 months
r-hFSH with HCG
Source sentences
Summary
Among the eight men who commenced r-hFSH treatment, seven demonstrated sperm output at a median of 6 months
1 context sentence(design, population, supporting numbers)
Summary · context
Ten men with gonadotrophin deficiency requiring induction of spermatogenesis and fertility were treated with HCG for 3-6 months followed by the s.c. self-administration of injections of r-hFSH in combination with HCG for 18 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-1035797201
02HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
In gonadotrophin-deficient men receiving r-hFSH with HCG, five achieved target sperm output at a median of 9 months.
In plain wordsIn gonadotrophin-deficient men receiving r-hFSH with HCG, five achieved the target sperm output at a median of 9 months.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseTarget sperm output
Study
n = 8
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Men reaching target sperm output
5 men (of 8 who started r-hFSH)
target 1. 5x10(6) per ml
Median time to target sperm output
9 months
of FSH treatment
Source sentences
Summary
Among the eight men who commenced r-hFSH treatment, seven demonstrated sperm output at a median of 6 months and five achieved the target sperm output of 1. 5x10(6) per ml at a median of 9 months of FSH treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Ten men with gonadotrophin deficiency requiring induction of spermatogenesis and fertility were treated with HCG for 3-6 months followed by the s.c. self-administration of injections of r-hFSH in combination with HCG for 18 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-1035797202
03HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
In gonadotrophin-deficient men receiving r-hFSH with HCG, mean testicular volume increased by 4.2 ml during FSH treatment.
In plain wordsIn gonadotrophin-deficient men receiving r-hFSH with HCG, mean testicular volume increased during FSH treatment.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseTesticular volume
Study
n = 8
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Mean testicular volume increase
4.2 ml
during FSH treatment
Source sentences
Summary
Mean testicular volume increased by 4.2 ml during FSH treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Ten men with gonadotrophin deficiency requiring induction of spermatogenesis and fertility were treated with HCG for 3-6 months followed by the s.c. self-administration of injections of r-hFSH in combination with HCG for 18 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-1035797203
04HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
In gonadotrophin-deficient men receiving r-hFSH with HCG, three men produced pregnancies in their partners.
In plain wordsIn gonadotrophin-deficient men receiving r-hFSH with HCG, three partners became pregnant.
Peptide
hCG (human chorionic gonadotropin)
Outcome
Not applicablePartner pregnancies
Study
n = 8
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Men with partner pregnancies
3 men
r-hFSH with HCG
Source sentences
Summary
Three men produced pregnancies in their partners, two of which resulted in the birth of healthy babies and a third patient's partner had a miscarriage.
1 context sentence(design, population, supporting numbers)
Summary · context
Ten men with gonadotrophin deficiency requiring induction of spermatogenesis and fertility were treated with HCG for 3-6 months followed by the s.c. self-administration of injections of r-hFSH in combination with HCG for 18 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-1035797204
05HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
Following r-hFSH with HCG in gonadotrophin-deficient men, two partner pregnancies resulted in healthy babies.
In plain wordsFollowing r-hFSH with HCG in gonadotrophin-deficient men, two partners gave birth to healthy babies.
Peptide
hCG (human chorionic gonadotropin)
Outcome
Not applicableHealthy live births
Study
n = 8
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Pregnancies resulting in healthy babies
2 pregnancies
of three partner pregnancies
Source sentences
Summary
Three men produced pregnancies in their partners, two of which resulted in the birth of healthy babies and a third patient's partner had a miscarriage.
1 context sentence(design, population, supporting numbers)
Summary · context
Ten men with gonadotrophin deficiency requiring induction of spermatogenesis and fertility were treated with HCG for 3-6 months followed by the s.c. self-administration of injections of r-hFSH in combination with HCG for 18 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-1035797205
06HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialSafety outcome
Following r-hFSH with HCG in gonadotrophin-deficient men, one partner had a miscarriage.
In plain wordsFollowing r-hFSH with HCG in gonadotrophin-deficient men, one partner had a miscarriage.
Peptide
hCG (human chorionic gonadotropin)
Outcome
Not applicablePartner miscarriage
Study
n = 8
Outcome group
Adverse events · Reproductive and sexual health
Measurements
Partners with miscarriage
1 partner
r-hFSH with HCG, the third patient's partner
Source sentences
Summary
Three men produced pregnancies in their partners, two of which resulted in the birth of healthy babies and a third patient's partner had a miscarriage.
1 context sentence(design, population, supporting numbers)
Summary · context
Ten men with gonadotrophin deficiency requiring induction of spermatogenesis and fertility were treated with HCG for 3-6 months followed by the s.c. self-administration of injections of r-hFSH in combination with HCG for 18 months.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-1035797206

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

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