Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures.

Andreassen TT, Ejersted C, Oxlund H

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 Jun 1999Cited by 247 (Europe PMC)

PMID10352105DOI10.1359/jbmr.1999.14.6.960PepBankPUB-10352105

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with tibial fractures, PTH increased ultimate load versus vehicle after 20 days.
In plain wordsIn rats, PTH increased fracture ultimate load compared with vehicle after 20 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFracture ultimate load at 20 days
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
200 microg/kg/day · 20 daysAs given in this study (rat).
Measurements
Ultimate load increase
75%
200 microg/kg/day at 20 days
Source sentences
Summary
The dose of 200 microg of PTH(1-34)/kg/day increased the ultimate load and the external callus volume of the fractures by 75% and 99%, respectively, after 20 days of healing and by 175% and 72%, respectively, after 40 days of healing.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with tibial fractures, PTH increased external callus volume versus vehicle after 20 days.
In plain wordsIn rats, PTH increased external callus volume compared with vehicle after 20 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseExternal callus volume at 20 days
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
200 microg/kg/day · 20 daysAs given in this study (rat).
Measurements
Callus volume increase
99%
200 microg/kg/day at 20 days
Source sentences
Summary
The dose of 200 microg of PTH(1-34)/kg/day increased the ultimate load and the external callus volume of the fractures by 75% and 99%, respectively, after 20 days of healing and by 175% and 72%, respectively, after 40 days of healing.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210502
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with tibial fractures, PTH increased ultimate load versus vehicle after 40 days.
In plain wordsIn rats, PTH increased fracture ultimate load compared with vehicle after 40 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFracture ultimate load at 40 days
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
200 microg/kg/day · 40 daysAs given in this study (rat).
Measurements
Ultimate load increase
175%
200 microg/kg/day at 40 days
Source sentences
Summary
The dose of 200 microg of PTH(1-34)/kg/day increased the ultimate load and the external callus volume of the fractures by 75% and 99%, respectively, after 20 days of healing and by 175% and 72%, respectively, after 40 days of healing.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with tibial fractures, PTH increased external callus volume versus vehicle after 40 days.
In plain wordsIn rats, PTH increased external callus volume compared with vehicle after 40 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseExternal callus volume at 40 days
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
200 microg/kg/day · 40 daysAs given in this study (rat).
Measurements
Callus volume increase
72%
200 microg/kg/day at 40 days
Source sentences
Summary
The dose of 200 microg of PTH(1-34)/kg/day increased the ultimate load and the external callus volume of the fractures by 75% and 99%, respectively, after 20 days of healing and by 175% and 72%, respectively, after 40 days of healing.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210504
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with tibial fractures, PTH did not affect ultimate load versus vehicle after 20 days.
In plain wordsIn rats, PTH did not affect fracture ultimate load compared with vehicle after 20 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeFracture ultimate load at 20 days
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg/day · 20 daysAs given in this study (rat).
Source sentences
Summary
The dose of 60 microg of PTH(1-34)/kg/day did not influence either ultimate load or external callus volume of the fractures after 20 days of healing, but the ultimate load was increased by 132% and the external callus volume was increased by 42% after 40 days of healing.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210505
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with tibial fractures, PTH did not affect external callus volume versus vehicle after 20 days.
In plain wordsIn rats, PTH did not affect external callus volume compared with vehicle after 20 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeExternal callus volume at 20 days
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg/day · 20 daysAs given in this study (rat).
Source sentences
Summary
The dose of 60 microg of PTH(1-34)/kg/day did not influence either ultimate load or external callus volume of the fractures after 20 days of healing, but the ultimate load was increased by 132% and the external callus volume was increased by 42% after 40 days of healing.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210506
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with tibial fractures, PTH increased ultimate load versus vehicle after 40 days.
In plain wordsIn rats, PTH increased fracture ultimate load compared with vehicle after 40 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFracture ultimate load at 40 days
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg/day · 40 daysAs given in this study (rat).
Measurements
Ultimate load increase
132%
60 microg/kg/day at 40 days
Source sentences
Summary
The dose of 60 microg of PTH(1-34)/kg/day did not influence either ultimate load or external callus volume of the fractures after 20 days of healing, but the ultimate load was increased by 132% and the external callus volume was increased by 42% after 40 days of healing.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210507
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with tibial fractures, PTH increased external callus volume versus vehicle after 40 days.
In plain wordsIn rats, PTH increased external callus volume compared with vehicle after 40 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseExternal callus volume at 40 days
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg/day · 40 daysAs given in this study (rat).
Measurements
Callus volume increase
42%
60 microg/kg/day at 40 days
Source sentences
Summary
The dose of 60 microg of PTH(1-34)/kg/day did not influence either ultimate load or external callus volume of the fractures after 20 days of healing, but the ultimate load was increased by 132% and the external callus volume was increased by 42% after 40 days of healing.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210508
09AnimalAnimal study (in vivo)Efficacy outcome
In rats with tibial fractures, PTH increased callus bone mineral content versus vehicle after 40 days.
In plain wordsIn rats, PTH increased callus bone mineral content compared with vehicle after 40 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus bone mineral content
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
200 microg/kg/day · 40 daysAs given in this study (rat).
Measurements
BMC increase
108%
200 microg/kg/day
Source sentences
Summary
After 40 days of healing, the callus BMC was increased by 108% in the 200 microg of PTH(1-34)/kg/day group and by 76% in the 60 microg of PTH(1-34)/kg/day group.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210509
10AnimalAnimal study (in vivo)Efficacy outcome
In rats with tibial fractures, PTH increased callus bone mineral content versus vehicle after 40 days.
In plain wordsIn rats, PTH increased callus bone mineral content compared with vehicle after 40 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus bone mineral content
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg/day · 40 daysAs given in this study (rat).
Measurements
BMC increase
76%
60 microg/kg/day
Source sentences
Summary
After 40 days of healing, the callus BMC was increased by 108% in the 200 microg of PTH(1-34)/kg/day group and by 76% in the 60 microg of PTH(1-34)/kg/day group.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210510
11AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased contralateral intact tibial bone mineral content versus vehicle at both assessment times.
In plain wordsIn rats, PTH increased intact tibial bone mineral content compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseIntact tibial bone mineral content
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg/day · 20 and 40 daysAs given in this study (rat).
Measurements
BMC increase
9%
20 days
BMC increase
19%
40 days
Source sentences
Summary
Both doses of PTH(1-34) steadily augmented the contralateral intact tibia BMC (20 days and 40 days: 60 microg of PTH (1-34)/kg/day 9% and 19%, respectively; 200 microg of PTH (1-34)/kg/day 12% and 27%, respectively)
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210511
12AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased contralateral intact tibial bone mineral content versus vehicle at both assessment times.
In plain wordsIn rats, PTH increased intact tibial bone mineral content compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseIntact tibial bone mineral content
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
200 microg/kg/day · 20 and 40 daysAs given in this study (rat).
Measurements
BMC increase
12%
20 days
BMC increase
27%
40 days
Source sentences
Summary
Both doses of PTH(1-34) steadily augmented the contralateral intact tibia BMC (20 days and 40 days: 60 microg of PTH (1-34)/kg/day 9% and 19%, respectively; 200 microg of PTH (1-34)/kg/day 12% and 27%, respectively)
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210512
13AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased contralateral intact tibial bone mineral density versus vehicle at both assessment times.
In plain wordsIn rats, PTH increased intact tibial bone mineral density compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseIntact tibial bone mineral density
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg/day · 20 and 40 daysAs given in this study (rat).
Measurements
BMD increase
11%
20 days
BMD increase
12%
40 days
Source sentences
Summary
and bone mineral density (20 days and 40 days: 60 microg of PTH(1-34)/kg/day 11% and 12%, respectively; 200 microg of PTH(1-34)/kg/day 11% and 15%, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210513
14AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased contralateral intact tibial bone mineral density versus vehicle at both assessment times.
In plain wordsIn rats, PTH increased intact tibial bone mineral density compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseIntact tibial bone mineral density
Study
ratn: not reported in source
Rats with tibial fractures
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
200 microg/kg/day · 20 and 40 daysAs given in this study (rat).
Measurements
BMD increase
11%
20 days
BMD increase
15%
40 days
Source sentences
Summary
and bone mineral density (20 days and 40 days: 60 microg of PTH(1-34)/kg/day 11% and 12%, respectively; 200 microg of PTH(1-34)/kg/day 11% and 15%, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intermittent parathyroid hormone (PTH(1-34)) administration on callus formation and mechanical strength of tibial fractures in rats was investigated after 20 and 40 days of healing. A dose of 60 microg of PTH(1-34)/kg/day and 200 microg of PTH(1-34)/kg/day, respectively, was adminis…
Report a problemFND-1035210514

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Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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