Sodium excretion and renin secretion after continuous versus pulsatile infusion of oxytocin in rats.

Sjöquist M, Huang W, Jacobsson E, Skøtt O, Stricker EM, Sved AF

Endocrinology1 Jun 1999Cited by 23 (Europe PMC)

PMID10342872DOI10.1210/endo.140.6.6831PepBankPUB-10342872

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized male rats, continuous oxytocin infusion increased renal sodium excretion 10-fold.
In plain wordsIn rats, a continuous oxytocin infusion raised sodium excretion in urine 10-fold.
Peptide
Oxytocin
Outcome
IncreaseRenal Na+ excretion, continuous infusion
Study
ratn: not reported in source
Male rats anesthetized with Inactin
Outcome group
Kidney function · Kidney and urinary
Studied dose
125 ng/kg x hAs given in this study (rat).
Measurements
Na+ excretion increase
10 fold
continuous infusion
Source sentences
Summary
renal Na+ excretion increased 10-fold, and urine volume and K+ excretion also were elevated.
1 context sentence(design, population, supporting numbers)
Summary · context
The present experiments compared the effects of continuous and pulsatile infusion of OT on natriuresis in rats.
Report a problemFND-1034287201
02AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized male rats, continuous oxytocin infusion increased urine volume.
In plain wordsIn rats, a continuous oxytocin infusion increased the amount of urine.
Peptide
Oxytocin
Outcome
IncreaseUrine volume, continuous infusion
Study
ratn: not reported in source
Male rats anesthetized with Inactin
Outcome group
Kidney function · Kidney and urinary
Studied dose
125 ng/kg x hAs given in this study (rat).
Source sentences
Summary
continuous infusion of OT (125 ng/kg x h) increased plasma OT to about 70 pg/ml; renal Na+ excretion increased 10-fold, and urine volume and K+ excretion also were elevated
1 context sentence(design, population, supporting numbers)
Summary · context
The present experiments compared the effects of continuous and pulsatile infusion of OT on natriuresis in rats.
Report a problemFND-1034287202
03AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized male rats, continuous oxytocin infusion increased urinary potassium excretion.
In plain wordsIn rats, a continuous oxytocin infusion increased potassium excretion in urine.
Peptide
Oxytocin
Outcome
IncreaseK+ excretion, continuous infusion
Study
ratn: not reported in source
Male rats anesthetized with Inactin
Outcome group
Kidney function · Kidney and urinary
Studied dose
125 ng/kg x hAs given in this study (rat).
Source sentences
Summary
continuous infusion of OT (125 ng/kg x h) increased plasma OT to about 70 pg/ml; renal Na+ excretion increased 10-fold, and urine volume and K+ excretion also were elevated
1 context sentence(design, population, supporting numbers)
Summary · context
The present experiments compared the effects of continuous and pulsatile infusion of OT on natriuresis in rats.
Report a problemFND-1034287203
04AnimalAnimal study (in vivo)Pharmacokinetics
In anesthetized male rats, continuous oxytocin infusion raised plasma oxytocin to about 70 pg/ml.
In plain wordsIn rats, a continuous oxytocin infusion raised oxytocin in blood to about 70 pg/ml.
Peptide
Oxytocin
Outcome
IncreasePlasma oxytocin during continuous infusion
Study
ratn: not reported in source
Male rats anesthetized with Inactin
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
125 ng/kg x hAs given in this study (rat).
Measurements
Plasma oxytocin
≈ 70 pg/ml
continuous infusion
Source sentences
Summary
continuous infusion of OT (125 ng/kg x h) increased plasma OT to about 70 pg/ml; renal Na+ excretion increased 10-fold, and urine volume and K+ excretion also were elevated.
1 context sentence(design, population, supporting numbers)
Summary · context
The present experiments compared the effects of continuous and pulsatile infusion of OT on natriuresis in rats.
Report a problemFND-1034287204
05AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized male rats, pulsatile oxytocin did not significantly increase urine volume versus vehicle.
In plain wordsIn rats, oxytocin given in pulses did not increase urine more than vehicle.
Peptide
Oxytocin
Outcome
No significant changeUrine volume, pulsatile infusion
Study
ratn: not reported in source
Male rats anesthetized with Inactin
Comparator
Vehicle
Outcome group
Kidney function · Kidney and urinary
Studied dose
same amount as continuous infusion, in pulses every 5 or 10 min · intravenousAs given in this study (rat).
Source sentences
Summary
However, when OT was administered i.v. in the same amount but in pulses given once every 5 or 10 min, to simulate the pattern of OT secretion during lactation, rats did not excrete significantly more urine, Na+, or K+ than did vehicle-treated animals.
1 context sentence(design, population, supporting numbers)
Summary · context
The present experiments compared the effects of continuous and pulsatile infusion of OT on natriuresis in rats.
Report a problemFND-1034287205
06AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized male rats, pulsatile oxytocin did not significantly increase sodium excretion versus vehicle.
In plain wordsIn rats, oxytocin given in pulses did not increase sodium excretion more than vehicle.
Peptide
Oxytocin
Outcome
No significant changeNa+ excretion, pulsatile infusion
Study
ratn: not reported in source
Male rats anesthetized with Inactin
Comparator
Vehicle
Outcome group
Kidney function · Kidney and urinary
Studied dose
same amount as continuous infusion, in pulses every 5 or 10 min · intravenousAs given in this study (rat).
Source sentences
Summary
However, when OT was administered i.v. in the same amount but in pulses given once every 5 or 10 min, to simulate the pattern of OT secretion during lactation, rats did not excrete significantly more urine, Na+, or K+ than did vehicle-treated animals.
1 context sentence(design, population, supporting numbers)
Summary · context
The present experiments compared the effects of continuous and pulsatile infusion of OT on natriuresis in rats.
Report a problemFND-1034287206
07AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized male rats, pulsatile oxytocin did not significantly increase potassium excretion versus vehicle.
In plain wordsIn rats, oxytocin given in pulses did not increase potassium excretion more than vehicle.
Peptide
Oxytocin
Outcome
No significant changeK+ excretion, pulsatile infusion
Study
ratn: not reported in source
Male rats anesthetized with Inactin
Comparator
Vehicle
Outcome group
Kidney function · Kidney and urinary
Studied dose
same amount as continuous infusion, in pulses every 5 or 10 min · intravenousAs given in this study (rat).
Source sentences
Summary
However, when OT was administered i.v. in the same amount but in pulses given once every 5 or 10 min, to simulate the pattern of OT secretion during lactation, rats did not excrete significantly more urine, Na+, or K+ than did vehicle-treated animals.
1 context sentence(design, population, supporting numbers)
Summary · context
The present experiments compared the effects of continuous and pulsatile infusion of OT on natriuresis in rats.
Report a problemFND-1034287207
08AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized male rats, continuous oxytocin infusion increased plasma renin concentration 2-fold.
In plain wordsIn rats, a continuous oxytocin infusion doubled the renin level in blood.
Peptide
Oxytocin
Outcome
IncreasePlasma renin concentration, continuous infusion
Study
ratn: not reported in source
Male rats anesthetized with Inactin
Outcome group
Kidney function · Kidney and urinary
Studied dose
125 ng/kg x hAs given in this study (rat).
Measurements
Plasma renin concentration increase
2 fold
continuous infusion
Source sentences
Summary
The plasma renin concentration, measured in these experiments because OT receptors are present in the macula densa, increased 2-fold when OT was infused either continuously or in pulses.
1 context sentence(design, population, supporting numbers)
Summary · context
The present experiments compared the effects of continuous and pulsatile infusion of OT on natriuresis in rats.
Report a problemFND-1034287208
09AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized male rats, pulsatile oxytocin infusion increased plasma renin concentration 2-fold.
In plain wordsIn rats, oxytocin given in pulses also doubled the renin level in blood.
Peptide
Oxytocin
Outcome
IncreasePlasma renin concentration, pulsatile infusion
Study
ratn: not reported in source
Male rats anesthetized with Inactin
Outcome group
Kidney function · Kidney and urinary
Studied dose
same amount as continuous infusion, in pulses every 5 or 10 min · intravenousAs given in this study (rat).
Measurements
Plasma renin concentration increase
2 fold
pulsatile infusion
Source sentences
Summary
The plasma renin concentration, measured in these experiments because OT receptors are present in the macula densa, increased 2-fold when OT was infused either continuously or in pulses.
1 context sentence(design, population, supporting numbers)
Summary · context
The present experiments compared the effects of continuous and pulsatile infusion of OT on natriuresis in rats.
Report a problemFND-1034287209

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.