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Study · Randomized controlled trial · n = 8 · 1999

5 results

Preservation of growth hormone secretion in response to growth hormone-releasing peptide-2 during prednisone therapy.

Meacham LR, Culler FL, Abdul-Latif H, Sullivan KM, Bowers CY

Metabolism: clinical and experimental1 May 1999Cited by 1 (Europe PMC)

PMID10337858 (opens in a new tab)DOI10.1016/s0026-0495(99)90055-0 (opens in a new tab)PepBankPUB-10337858
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialActivity measurement

    In eight subjects, the peak GH response to GHRP‑2 did not change significantly during prednisone therapy.

    In plain wordsIn eight people, prednisone did not significantly reduce the peak growth hormone response to GHRP‑2.

    Peptide
    GHRP-2
    Outcome
    No significant changePeak GH after GHRP-2 before and during prednisone
    Study

    n = 8

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Peak GH
    80.8 microg/L
    GHRP-2 before prednisone
    Peak GH
    71.3 microg/L
    GHRP-2 during prednisone

    Source sentences

    Summary
    Before prednisone, peak GH levels in response to arginine and GHRP-2 were 8.8 +/- 2.8 and 80.8 +/- 21.2 microg/L. During prednisone therapy, the peak GH level in response to arginine and to GHRP-2 was 20.1 +/- 8.3 and 71.3 +/- 18.4 microg/L, respectively. The difference in peak values before and aft…
    2 context sentences
    Summary · context
    We measured the ability of GHRP-2 to release GH before and during prednisone therapy (20 mg orally three times daily for 4 days).
    Summary · context
    GH release in response to GHRP-2 and arginine was measured in the same eight subjects before and during prednisone therapy.
  2. 02HumanRandomized controlled trialActivity measurement

    In eight subjects, time to the peak GH level after GHRP‑2 occurred sooner during prednisone therapy.

    In plain wordsIn eight people, growth hormone peaked sooner after GHRP‑2 during prednisone therapy.

    Peptide
    GHRP-2
    Outcome
    DecreaseTime to peak GH during prednisone
    Study

    n = 8

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The time to the peak GH level during prednisone therapy occurred sooner for both arginine and GHRP-2.
    2 context sentences
    Summary · context
    We measured the ability of GHRP-2 to release GH before and during prednisone therapy (20 mg orally three times daily for 4 days).
    Summary · context
    GH release in response to GHRP-2 and arginine was measured in the same eight subjects before and during prednisone therapy.
  3. 03HumanRandomized controlled trialActivity measurement

    In eight subjects, the mean area under the curve for GH release to GHRP‑2 decreased significantly with prednisone treatment (P = .04).

    In plain wordsIn eight people, the total growth hormone released after GHRP‑2 was smaller during prednisone.

    Peptide
    GHRP-2
    Outcome
    DecreaseGH AUC after GHRP-2 during prednisone
    Study

    n = 8

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The pattern of GH release to arginine and to GHRP-2 was not identical, and the mean area under the curve for GH release to GHRP-2 decreased significantly with steroid treatment (P = .04), suggesting that GHRP-2 acts by mechanisms additional to the removal of SRIF inhibition.
    2 context sentences
    Summary · context
    We measured the ability of GHRP-2 to release GH before and during prednisone therapy (20 mg orally three times daily for 4 days).
    Summary · context
    GH release in response to GHRP-2 and arginine was measured in the same eight subjects before and during prednisone therapy.
  4. 04HumanRandomized controlled trialActivity measurement

    In eight subjects, GHRP‑2 elicited a 10-fold greater GH response than arginine at baseline.

    In plain wordsIn eight people, GHRP‑2 released 10 times more growth hormone than arginine before prednisone.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH response to GHRP-2 versus arginine at baseline
    Study

    n = 8

    Comparator
    Arginine
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    GH response ratio
    10 fold
    GHRP-2 versus arginine, baseline

    Source sentences

    Summary
    GHRP-2 elicited a 10-fold greater GH response than arginine at baseline, and the GH response was threefold greater versus arginine even in the face of prednisone therapy.
    2 context sentences
    Summary · context
    We measured the ability of GHRP-2 to release GH before and during prednisone therapy (20 mg orally three times daily for 4 days).
    Summary · context
    GH release in response to GHRP-2 and arginine was measured in the same eight subjects before and during prednisone therapy.
  5. 05HumanRandomized controlled trialActivity measurement

    In eight subjects, the GH response to GHRP‑2 stayed threefold greater than to arginine during prednisone therapy.

    In plain wordsIn eight people, GHRP‑2 still released three times more growth hormone than arginine during prednisone.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH response to GHRP-2 versus arginine during prednisone
    Study

    n = 8

    Comparator
    Arginine
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-2 elicited a 10-fold greater GH response than arginine at baseline, and the GH response was threefold greater versus arginine even in the face of prednisone therapy.
    2 context sentences
    Summary · context
    We measured the ability of GHRP-2 to release GH before and during prednisone therapy (20 mg orally three times daily for 4 days).
    Summary · context
    GH release in response to GHRP-2 and arginine was measured in the same eight subjects before and during prednisone therapy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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