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Study · Randomized controlled trial · n = 20 · 1999

11 results

Comparison of the anabolic effects and complications of human growth hormone and the testosterone analog, oxandrolone, after severe burn injury.

Demling RH

Burns : journal of the International Society for Burn Injuries1 May 1999Cited by 73 (Europe PMC)

PMID10323605 (opens in a new tab)DOI10.1016/s0305-4179(98)00159-4 (opens in a new tab)PepBankPUB-10323605
Publisher pagePubMedAsk about this study
Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In severe burn patients, net weight loss was 4 +/- 1.8 kg with HGH and 3 +/- 1.2 kg with oxandrolone; the authors described the two agents as having nearly identical benefits.

    In plain wordsIn severe burn patients, weight loss was 4 kg with HGH and 3 kg with oxandrolone, which the authors called nearly identical.

    Peptide
    HGH (somatotropin)
    Outcome
    Direction not reportedNet weight loss versus oxandrolone
    Study

    n: not reported in source

    Comparator
    Oxandrolone
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.1 mg/kg/dayAs given in this study (human).

    Measurements

    Net weight loss
    4 kg
    HGH group; reported as 4 +/- 1.8 kg
    Net weight loss
    3 kg
    Oxandrolone group; reported as 3 +/- 1.2 kg

    Source sentences

    Summary
    Net weight loss was 8 +/- 2.1 kg in the control group compared with 4 +/- 1.8 kg with HGH and 3 +/- 1.2 kg with oxandrolone, a significant decrease.
    3 context sentences
    Summary · context
    A randomized prospective study design was used.
    Summary · context
    Patients were given HGH at a dose of 0.1 mg/kg/day (n = 20) or oxandrolone, 20 mg/day (n = 16), beginning between days 7-10 post-burn.
    Summary · context
    Data was compared to burn patients not placed on either agent (n = 24).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In severe burn patients, daily nitrogen loss was 3 g or less in both HGH and oxandrolone groups.

    In plain wordsIn severe burn patients, daily nitrogen loss was three grams or less with both HGH and oxandrolone.

    Peptide
    HGH (somatotropin)
    Outcome
    Direction not reportedDaily nitrogen loss versus oxandrolone
    Study

    n: not reported in source

    Comparator
    Oxandrolone
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    0.1 mg/kg/dayAs given in this study (human).

    Measurements

    Net daily nitrogen loss
    ≤ 3 g
    HGH group; reported as 3 g or less
    Net daily nitrogen loss
    ≤ 3 g
    Oxandrolone group; reported as 3 g or less

    Source sentences

    Summary
    Net daily nitrogen loss was 12 +/- 3 g in non-treated compared to 3 g or less for each of the anabolic groups, a significant decrease.
    3 context sentences
    Summary · context
    Patients were given HGH at a dose of 0.1 mg/kg/day (n = 20) or oxandrolone, 20 mg/day (n = 16), beginning between days 7-10 post-burn.
    Summary · context
    A randomized prospective study design was used.
    Summary · context
    Data was compared to burn patients not placed on either agent (n = 24).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In severe burn patients, metabolic rate was 178 +/- 28% of predicted normal with HGH versus 156 +/- 20% with oxandrolone.

    In plain wordsIn severe burn patients, metabolic rate was higher with HGH than oxandrolone.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseMetabolic rate versus oxandrolone
    Study

    n: not reported in source

    Comparator
    Oxandrolone
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    0.1 mg/kg/dayAs given in this study (human).

    Measurements

    Metabolic rate
    178 % of predicted normal
    HGH group; reported as 178 +/- 28%
    Metabolic rate
    156 % of predicted normal
    Oxandrolone group; reported as 156 +/- 20%

    Source sentences

    Summary
    The metabolic rate in untreated burns was 155 + 25% of predicted normal, compared to 178 +/- 28% for HGH and 156 +/- 20% for oxandrolone treated patients.
    3 context sentences
    Summary · context
    A randomized prospective study design was used.
    Summary · context
    Patients were given HGH at a dose of 0.1 mg/kg/day (n = 20) or oxandrolone, 20 mg/day (n = 16), beginning between days 7-10 post-burn.
    Summary · context
    Data was compared to burn patients not placed on either agent (n = 24).
  4. 04HumanRandomized controlled trialEfficacy outcome

    In severe burn patients, donor site healing time was 10 +/- 3 days with HGH versus 10 +/- 2 days with oxandrolone.

    In plain wordsIn severe burn patients, mean donor site healing time was ten days with both HGH and oxandrolone.

    Peptide
    HGH (somatotropin)
    Outcome
    Direction not reportedDonor site healing versus oxandrolone
    Study

    n: not reported in source

    Comparator
    Oxandrolone
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    0.1 mg/kg/dayAs given in this study (human).

    Measurements

    Complete healing time of standardized donor site
    10 days
    HGH group; reported as 10 +/- 3 days
    Complete healing time of standardized donor site
    10 days
    Oxandrolone group; reported as 10 +/- 2 days

    Source sentences

    Summary
    The complete healing time of a standardized donor site, decreased from the control value of 14 +/- 2 days to 10 +/- 3 days for HGH and 10 +/- 2 days for oxandrolone treated patients, a significant improvement.
    3 context sentences
    Summary · context
    A randomized prospective study design was used.
    Summary · context
    Patients were given HGH at a dose of 0.1 mg/kg/day (n = 20) or oxandrolone, 20 mg/day (n = 16), beginning between days 7-10 post-burn.
    Summary · context
    Data was compared to burn patients not placed on either agent (n = 24).
  5. 05HumanRandomized controlled trialSafety outcome

    In severe burn patients, hyperglycemia above 225 mg/dl occurred in 100% with HGH versus 50% with oxandrolone.

    In plain wordsIn severe burn patients, hyperglycemia occurred more often with HGH than oxandrolone.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseHyperglycemia versus oxandrolone
    Study

    n: not reported in source

    Comparator
    Oxandrolone
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.1 mg/kg/dayAs given in this study (human).

    Measurements

    Hyperglycemia (glucose over 225 mg/dl, 12.5 mM)
    100 % of patients
    HGH group
    Hyperglycemia (glucose over 225 mg/dl, 12.5 mM)
    50 % of patients
    Oxandrolone group

    Source sentences

    Summary
    Hyperglycemia (glucose over 225 mg/dl 12.5 mM) was present in 100% of HGH patients compared to 55% for control and 50% for oxandrolone treated.
    3 context sentences
    Summary · context
    A randomized prospective study design was used.
    Summary · context
    Patients were given HGH at a dose of 0.1 mg/kg/day (n = 20) or oxandrolone, 20 mg/day (n = 16), beginning between days 7-10 post-burn.
    Summary · context
    Data was compared to burn patients not placed on either agent (n = 24).
  6. 06HumanNon-randomized trialSafety outcome

    In severe burn patients receiving HGH, all patients survived.

    In plain wordsIn severe burn patients receiving HGH, all patients survived.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableSurvival
    Study

    n = 20

    Outcome group
    Mortality · Whole body
    Studied dose
    0.1 mg/kg/dayAs given in this study (human).

    Source sentences

    Summary
    All patients survived.
    3 context sentences
    Summary · context
    A randomized prospective study design was used.
    Summary · context
    Patients were given HGH at a dose of 0.1 mg/kg/day (n = 20) or oxandrolone, 20 mg/day (n = 16), beginning between days 7-10 post-burn.
    Summary · context
    Data was compared to burn patients not placed on either agent (n = 24).
  7. 07HumanNon-randomized trialEfficacy outcome

    In severe burn patients, net weight loss was 4 +/- 1.8 kg with HGH versus 8 +/- 2.1 kg in untreated controls, a significant reduction.

    In plain wordsIn severe burn patients, HGH reduced weight loss compared with untreated controls.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseNet weight loss versus untreated controls
    Study

    n: not reported in source

    Comparator
    Untreated burn controls
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.1 mg/kg/dayAs given in this study (human).

    Measurements

    Net weight loss
    8 kg
    Untreated control group; reported as 8 +/- 2.1 kg
    Net weight loss
    4 kg
    HGH group; reported as 4 +/- 1.8 kg

    Source sentences

    Summary
    Net weight loss was 8 +/- 2.1 kg in the control group compared with 4 +/- 1.8 kg with HGH and 3 +/- 1.2 kg with oxandrolone, a significant decrease.
    3 context sentences
    Summary · context
    A randomized prospective study design was used.
    Summary · context
    Patients were given HGH at a dose of 0.1 mg/kg/day (n = 20) or oxandrolone, 20 mg/day (n = 16), beginning between days 7-10 post-burn.
    Summary · context
    Data was compared to burn patients not placed on either agent (n = 24).
  8. 08HumanNon-randomized trialEfficacy outcome

    In severe burn patients, daily nitrogen loss was 3 g or less with HGH versus 12 +/- 3 g untreated, a significant reduction.

    In plain wordsIn severe burn patients, HGH reduced daily nitrogen loss compared with untreated controls.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseDaily nitrogen loss versus untreated controls
    Study

    n: not reported in source

    Comparator
    Untreated burn controls
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    0.1 mg/kg/dayAs given in this study (human).

    Measurements

    Net daily nitrogen loss
    12 g
    Untreated control group; reported as 12 +/- 3 g
    Net daily nitrogen loss
    ≤ 3 g
    HGH group; reported as 3 g or less for each anabolic group

    Source sentences

    Summary
    Net daily nitrogen loss was 12 +/- 3 g in non-treated compared to 3 g or less for each of the anabolic groups, a significant decrease.
    3 context sentences
    Summary · context
    A randomized prospective study design was used.
    Summary · context
    Patients were given HGH at a dose of 0.1 mg/kg/day (n = 20) or oxandrolone, 20 mg/day (n = 16), beginning between days 7-10 post-burn.
    Summary · context
    Data was compared to burn patients not placed on either agent (n = 24).
  9. 09HumanNon-randomized trialEfficacy outcome

    In severe burn patients, metabolic rate was 178 +/- 28% of predicted normal with HGH versus 155 + 25% untreated.

    In plain wordsIn severe burn patients, metabolic rate was higher with HGH than in untreated controls.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseMetabolic rate versus untreated controls
    Study

    n: not reported in source

    Comparator
    Untreated burn controls
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    0.1 mg/kg/dayAs given in this study (human).

    Measurements

    Metabolic rate
    155 % of predicted normal
    Untreated burn control group; reported as 155 + 25%
    Metabolic rate
    178 % of predicted normal
    HGH group; reported as 178 +/- 28%

    Source sentences

    Summary
    The metabolic rate in untreated burns was 155 + 25% of predicted normal, compared to 178 +/- 28% for HGH and 156 +/- 20% for oxandrolone treated patients.
    3 context sentences
    Summary · context
    A randomized prospective study design was used.
    Summary · context
    Patients were given HGH at a dose of 0.1 mg/kg/day (n = 20) or oxandrolone, 20 mg/day (n = 16), beginning between days 7-10 post-burn.
    Summary · context
    Data was compared to burn patients not placed on either agent (n = 24).
  10. 10HumanNon-randomized trialEfficacy outcome

    In severe burn patients, donor site healing time was 10 +/- 3 days with HGH versus 14 +/- 2 days untreated, a significant reduction.

    In plain wordsIn severe burn patients, HGH shortened donor site healing time compared with untreated controls.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseDonor site healing versus untreated controls
    Study

    n: not reported in source

    Comparator
    Untreated burn controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    0.1 mg/kg/dayAs given in this study (human).

    Measurements

    Complete healing time of standardized donor site
    14 days
    Untreated control group; reported as 14 +/- 2 days
    Complete healing time of standardized donor site
    10 days
    HGH group; reported as 10 +/- 3 days

    Source sentences

    Summary
    The complete healing time of a standardized donor site, decreased from the control value of 14 +/- 2 days to 10 +/- 3 days for HGH and 10 +/- 2 days for oxandrolone treated patients, a significant improvement.
    3 context sentences
    Summary · context
    A randomized prospective study design was used.
    Summary · context
    Patients were given HGH at a dose of 0.1 mg/kg/day (n = 20) or oxandrolone, 20 mg/day (n = 16), beginning between days 7-10 post-burn.
    Summary · context
    Data was compared to burn patients not placed on either agent (n = 24).
  11. 11HumanNon-randomized trialSafety outcome

    In severe burn patients, hyperglycemia above 225 mg/dl occurred in 100% with HGH versus 55% of controls.

    In plain wordsIn severe burn patients, hyperglycemia occurred more often with HGH than in untreated controls.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseHyperglycemia versus untreated controls
    Study

    n: not reported in source

    Comparator
    Untreated burn controls
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.1 mg/kg/dayAs given in this study (human).

    Measurements

    Hyperglycemia (glucose over 225 mg/dl, 12.5 mM)
    100 % of patients
    HGH group
    Hyperglycemia (glucose over 225 mg/dl, 12.5 mM)
    55 % of patients
    Untreated control group

    Source sentences

    Summary
    Hyperglycemia (glucose over 225 mg/dl 12.5 mM) was present in 100% of HGH patients compared to 55% for control and 50% for oxandrolone treated.
    3 context sentences
    Summary · context
    A randomized prospective study design was used.
    Summary · context
    Patients were given HGH at a dose of 0.1 mg/kg/day (n = 20) or oxandrolone, 20 mg/day (n = 16), beginning between days 7-10 post-burn.
    Summary · context
    Data was compared to burn patients not placed on either agent (n = 24).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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