Effects of continuous infusion of PTH on experimental tooth movement in rats.

Soma S, Iwamoto M, Higuchi Y, Kurisu K

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 Apr 1999Cited by 52 (Europe PMC)

PMID10234575DOI10.1359/jbmr.1999.14.4.546PepBankPUB-10234575

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH(1-84) infusion accelerated first molar movement during 72 h of elastic-band force versus vehicle.
In plain wordsIn rats, PTH(1-84) infusion accelerated tooth movement under elastic-band force compared with vehicle.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseElastic-band tooth movement
Study
ratn: not reported in source
orthodontic tooth movement
Comparator
vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 micrograms/100 g body weight/day · subcutaneous continuous infusionAs given in this study (rat).
Source sentences
Summary
When the upper right first molar (M1) was moved mesially for 72 h by the insertion of an elastic band between the first and second molars, M1 movement was accelerated by PTH infusion at 10 micrograms.
1 context sentence(design, population, supporting numbers)
Summary · context
Male rats weighing 350-400 g were treated with subcutaneous of vehicle or hPTH(1-84) at 1-10 micrograms/100 g of body weight/day.
Report a problemFND-1023457501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH infusion increased osteoclast number in compressed molar periodontium 2- to 3-fold versus vehicle.
In plain wordsIn rats, PTH infusion increased bone-resorbing cell numbers around the compressed tooth 2- to 3-fold compared with vehicle.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreasePeriodontal osteoclast number
Study
ratn: not reported in source
orthodontic tooth movement
Comparator
vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous continuous infusionAs given in this study (rat).
Measurements
Osteoclast number increase
2 to 3 fold
compressed periodontium
Source sentences
Summary
PTH infusion caused a 2- to 3-fold increase in the number of osteoclasts in the compressed periodontium of M1, indicating that such treatment accelerated tooth movement by enhancing bone resorptive activity induced in the compressed periodontium.
1 context sentence(design, population, supporting numbers)
Summary · context
Male rats weighing 350-400 g were treated with subcutaneous of vehicle or hPTH(1-84) at 1-10 micrograms/100 g of body weight/day.
Report a problemFND-1023457502
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH(1-84) infusion doubled first molar movement rate during 12 days of coil-spring force versus vehicle.
In plain wordsIn rats, PTH(1-84) infusion doubled tooth movement under coil-spring force compared with vehicle.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseCoil-spring tooth movement rate
Study
ratn: not reported in source
orthodontic tooth movement
Comparator
vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 micrograms/100 g body weight/day · subcutaneous continuous infusionAs given in this study (rat).
Measurements
Tooth movement rate increase
2 fold
coil spring
Source sentences
Summary
When M1 was moved mesially by an orthodontic coil spring ligated between upper incisors and M1 for 12 days, PTH(1-84) infusion at 10 micrograms caused a 2-fold increase in the rate of M1 movement.
1 context sentence(design, population, supporting numbers)
Summary · context
Male rats weighing 350-400 g were treated with subcutaneous of vehicle or hPTH(1-84) at 1-10 micrograms/100 g of body weight/day.
Report a problemFND-1023457503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH(1-84) infusion had a tooth movement effect comparable to PTH(1-34) infusion at 4 micrograms.
In plain wordsIn rats, PTH(1-84) infusion accelerated tooth movement similarly to PTH(1-34) infusion.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeTooth movement versus PTH(1-34)
Study
ratn: not reported in source
orthodontic tooth movement
Comparator
PTH(1-34) infusion at 4 micrograms
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 micrograms/100 g body weight/day · subcutaneous continuous infusionAs given in this study (rat).
Source sentences
Summary
PTH(1-34) infusion at 4 micrograms had an effect comparable to that of PTH(1-84).
2 context sentences(design, population, supporting numbers)
Summary · context
When M1 was moved mesially by an orthodontic coil spring ligated between upper incisors and M1 for 12 days, PTH(1-84) infusion at 10 micrograms caused a 2-fold increase in the rate of M1 movement.
Summary · context
Male rats weighing 350-400 g were treated with subcutaneous of vehicle or hPTH(1-84) at 1-10 micrograms/100 g of body weight/day.
Report a problemFND-1023457504
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH infusion did not affect bone mineral measurements versus vehicle.
In plain wordsIn rats, PTH infusion did not change bone mineral measurements compared with vehicle.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeBone mineral measurements
Study
ratn: not reported in source
orthodontic tooth movement
Comparator
vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous continuous infusion · 13 daysAs given in this study (rat).
Source sentences
Summary
PTH infusion for 13 days did not affect either bone mineral measurements or the serum calcium level.
1 context sentence(design, population, supporting numbers)
Summary · context
Male rats weighing 350-400 g were treated with subcutaneous of vehicle or hPTH(1-84) at 1-10 micrograms/100 g of body weight/day.
Report a problemFND-1023457505
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH infusion did not affect serum calcium versus vehicle.
In plain wordsIn rats, PTH infusion did not change blood calcium compared with vehicle.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeSerum calcium
Study
ratn: not reported in source
orthodontic tooth movement
Comparator
vehicle
Outcome group
Electrolyte balance · Endocrine and hormones
Studied dose
Dose not stated · subcutaneous continuous infusion · 13 daysAs given in this study (rat).
Source sentences
Summary
PTH infusion for 13 days did not affect either bone mineral measurements or the serum calcium level.
1 context sentence(design, population, supporting numbers)
Summary · context
Male rats weighing 350-400 g were treated with subcutaneous of vehicle or hPTH(1-84) at 1-10 micrograms/100 g of body weight/day.
Report a problemFND-1023457506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

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